Molecular Instruments

We have exciting news to share! Molecular Instruments has won the UK lawsuit brought by Advanced Cell Diagnostics (a Bio-Techne group company), with the Court finding that two patents owned by Advanced Cell Diagnostics are invalid on obviousness grounds. Please see the press release linked below for more details. We look forward to continuing our mission to provide game-changing #onlywithHCR reagents to biologists, bioengineers, drug developers, and diagnostics developers worldwide. To learn more about our HCR??imaging platform, check out our Automated Products (www.hcrimaging.com) and our Manual Products (https://lnkd.in/gJZePKk). https://lnkd.in/g_WfxEjF

Introducing our new social media segment: #BehindMI! First up, meet our Business Development Team! Say hello to?Michelle Saylor, our Associate Director of Business Development, and?Joseph Melko, our Senior Business Development Associate! With their customer success and support expertise, Michelle and Joseph ensure our clients receive exceptional service while driving innovation and growth. Together, they are dedicated to advancing our mission and building strong partnerships within the scientific community.

#onlywithHCR: Visualizing Lymphatic Endothelial Cell Formation in Mammalian Vasculature??? A groundbreaking study from Lupu et al. challenges traditional views on the formation of lymphatic endothelial cells in mammals. Previously, it was believed that these cells emerged from a common pool of progenitor cells through a process of differentiation. However, their research reveals that lymphatic endothelial cells are actually derived from a specialized population of progenitors. By using #HCRtechnology, the authors were able to validate their scRNA-seq analysis and visualize endothelial progenitors co-expressing master regulators, Etv2 (endothelial) and Prox1 (lymphatic) in whole-mount mouse embryos. Explore Oliver Stone, David Grainger, and their team's exciting study on Nature Magazine here:?https://lnkd.in/gz5v_ibH

Last week, we had the pleasure of hosting the first-ever HCR? User Symposium in San Diego! A huge thank you to our attendees and speakers for making this event a success. We're especially grateful to Deborah Yelon, Anne Hellebust, Nipam Patel, Xiaoshan Wang, and Elliot Perens for sharing their expertise and fostering insightful discussions. This is just the beginning — exciting developments are coming soon! Stay tuned for more updates and future events.

#onlywithHCR: HCR? Technology Enhances Butterfly Brain Gene Mapping ?? In this study on?Bicyclus anynana, HCR? technology played a pivotal role in visualizing gene expression in the larval brain. By optimizing the protocol, Banerjee et al. were able to map the expression of ten specific genes in whole brain tissue with single-cell resolution. The precision of HCR? imaging allowed them to capture detailed expression domains of genes like optomotor blind (omb), Synapsin, and SNAI2, which are crucial for understanding brain functions and behaviors. Check out the full study here:?https://lnkd.in/gfGnZXbZ

William Damsky, MD, PhD is advancing inflammatory skin disease diagnoses with his HCR? Pro-powered LDT! His groundbreaking work is enabling precise molecular diagnostics for conditions like atopic dermatitis and psoriasis, all while simplifying the process for clinicians. This new in-depth coverage from Dermatology Times showcases the innovative LDT panel, further highlighting Bill's transformative impact on diagnostic workflows. Read more about it here:?https://lnkd.in/gUQFAyPY

#onlywithHCR: Visualizing RNA Expression in Drosophila Pupal Development??? A study on Drosophila by Bayala et al. highlights a novel protocol using HCR? technology to study RNA expression in the fragile and impermeable tissues of the Drosophila epidermis during pupal development. Erick Bayala and his co-authors describe a method for dissecting tissue and detecting RNA across various stages, including early and late pupal stages, as well as larval imaginal discs. Powered by HCR? imaging, this approach allows for the study of dynamic gene expression patterns throughout the pupal development process, overcoming the challenges of tissue fragility and impermeability. Learn more about the study here:?https://lnkd.in/grsRT6XA

Discover how to enhance RNA-ISH spot detection with dual-channel staining and AI analysis in our exciting upcoming webinar! ????March 18, 2025 ????9:00 AM PDT Join us and Visiopharm to learn how Dual Channel? Validation and AI-powered Discovery software optimize RNA-ISH assays for precise RNA detection and quantification, even in challenging tissue samples. ?? Register here:?https://lnkd.in/dGCHs2Ta

At MI, we know that stepping into the great outdoors can inspire fresh ideas and bring a sense of calm to your mind! This week's #MIrecommendation comes from our CEO,?Harry Choi, who recently visited Banff National Park. He says, "After visiting Banff National Park over Thanksgiving, I can’t recommend it enough—you are constantly surrounded by breathtaking views. The snow-covered peaks, the crisp mountain air, and the absolute peace of standing above the clouds made it an unforgettable experience. Whether you’re skiing, hiking, or just soaking in the scenery, Banff in winter is pure magic." Looking for an unforgettable escape and a chance to recharge in nature? Banff National Park could be just the place to reconnect with the beauty of the world around you!

Today, on Employee Appreciation Day, we want to express our heartfelt thanks to the incredible team that fuels our success at MI. Your dedication, creativity, and passion are the foundation of everything we do. We truly appreciate each of you for your invaluable contributions in bringing our mission to life. Thank you for your unwavering commitment and outstanding work. ??