Modern Pathology

In the week of #WorldCancerDay - we are excited to share our latest publication news for #MammaTyper. Published in Modern Pathology from Elsevier comes Emad Rakha and Nehal Atallah's research article: ?? ???????????????????? ???? ???????????????? ???? ????????-???????? ?????????????? ?????????? ?? ?????????????????? ?????????? ?? HER2-positive breast cancer which constitutes 13-15% of cases, shows variable response to anti-HER2 therapies.?The refinement of HER2 classification for prediction of response to anti-HER2 therapy can improve breast cancer (BC) patients’ outcomes. This is where MammaTyper?can help! By combining MammaTyper? assay with IHC to assess HER2 status, you can improve the identification of HER2-positive BC patients who would benefit from anti-HER2 therapy. #Innovation #Diagnostics #BreastCancer

A new multicenter, retrospective study published in Modern Pathology quantifies the performance of the Scopio Full-Field Bone Marrow Aspirate Application vs. manual microscopy. Authored by Adam Bagg, Philipp W. Raess, Irit Avivi, and Ben-Zion Katz, the evaluation demonstrated the digital system’s potential for accurate, high-quality BMA analysis and for accelerating expert analysis. Conducted at The Hospital of the University of Pennsylvania, Oregon Health & Science University, and Tel Aviv Sourasky Medical Center, the study assessed BMA primary parameters (normal or abnormal) and secondary parameters (increased/decreased/ normal). The results showed a high correlation with manual methods for Romanowsky-stained samples and Prussian blue-stained samples, respectively, as follows: ? Efficiency: 90.85%/90.00% ? Sensitivity:? 81.61%/81.94% ? Specificity: 92.88%/93.38% respectively Overall agreement was 91.1%, with repeatability and reproducibility within predefined criteria. Access the article at:? https://lnkd.in/dJ6tmwZ3

I’m incredibly proud to share our new publication on RET-fused Spitz tumors, providing novel clinical, genomic and morphologic insights, led by the remarkable efforts of Michele Donati. Just published in Modern Pathology. Here is the link to the publication:

Congratulations to Dimitris Goutas the research team on this important publication in Modern Pathology! Advancing our understanding of RET-fused Spitz tumors is a significant contribution to the field, and we are always excited to see groundbreaking work from our colleagues. We encourage everyone in the pathology and oncology community to check out this insightful study! #Pathology #CancerResearch #Genomics #SpitzTumors #ModernPathology #PrecisionMedicine”

?? I'm thrilled to share our new paper, just published in the prestigious journal Modern Pathology!???? In this work, using an integrated approach combining clinical, morphological, immunohistochemical, and molecular profiling analyses, we confirmed that MEF2D::NCOA2 fusion associated tumors of the vulva/vagina represent a distinct entity. Given the rarity of this tumor, this work was possible thanks to a close national collaboration between Hospices Civils de Lyon - HCL, IUCT-Oncopole, Institut Bergonié, and Centre Léon Bérard ???? Why is it crucial to describe new entities like this one ? ?? In this particular case, because of the differential diagnoses (especially myxoid STUMP and leiomyosarcoma) some patients would have been treated aggressively, whereas the clinical behavior of this entity appears rather indolent, requiring surgical excision only. However, more data are needed to really understand the biology of these neoplams. Free access here: https://lnkd.in/e-UwXpkS Mojgan Devouassoux-Shisheboran, Guillaume Bataillon, sabrina croce, Fran?ois Le Loarer, Isabelle Treilleux, Daniel Pissaloux, Brice Thamphya, Jonathan Lopez, Fran?oise Descotes, Marie Donzel, Eudeline Alix, Recherche en santé HCL, Institut de cancérologie HCL, Université Claude Bernard Lyon 1 #CICLY.

Diagnostic and Prognostic/Therapeutic Significance of Comprehensive Analysis of Bone and Soft Tissue Tumors Using Optical Genome Mapping and Next-generation Sequencing Newly published in Modern Pathology by members of the Hopkins pathology community. https://lnkd.in/eYbcqdqd

USCAP - United States and Canadian Academy of Pathology is searching for an EDITOR-IN-CHIEF of Modern Pathology! ?????? ???????????????????????????????? ? The Editor-in-Chief is responsible for overseeing the journal’s scientific content and has final authority in all decisions regarding manuscript publication status. The Editor-in-Chief must be able to interact effectively with USCAP Staff, the USCAP Publications Committee, the journal’s Editorial Board Members, contributing authors, and the journal’s representatives at Elsevier. The Editor-in-Chief reports to the USCAP Publications Committee and the USCAP Board of Directors. USCAP provides the funding and the staff for the editorial office. ???????????????????????????? ?Nationally and internationally recognized #pathologist ?Academic faculty appointment or equivalent position ?Physician-investigator practicing subspecialty pathology and advancing the practice of pathology ?Proven record as an active, engaged editorial board member of a high-quality journal ?Current member of #USCAP who supports the academy’s mission ?Team builder and inclusive leader who can manage the Editorial Board effectively and work closely with the Managing Editor and Assistant Managing Editor ?Sufficient time and effort to meet the editorial and administrative demands of a world-class academic journal ?Visionary leader with an eye to the future of the discipline, its practice and investigation ?Forward-looking and innovative individual with creative approaches to communicating and disseminating information ?Reputation for fairness, integrity and supporting diversity and inclusivity in the workplace ?????????????? ?????????????? ?????????????????? ?????? ???????????????? ?????? ???? ?????????? ????: ??????????://??????????.??????/????????????-??????????????????-????????????-????-??????????/ Have questions? Email the Search Committee at?[email protected] ?? Application Deadline: August 16th, 2024??

Do you know Intraductal Oncocytic Pancreatic Neoplasms ?? ?! IOPN have distinct features ?? new review out now Modern Pathology ?? M:F 1.5: 1 / median size 50 mm / more frequent in the head ?? 50% are invasive / good long term survival ?? Classic pancreatic drivers less altered! https://lnkd.in/d6D5ctH6

Our APRIL cover is ABSOLUTELY STUNNING! Figure 1 from a research article in our most recent April issue: "Quantitative Multiplexed Analysis of Indoleamine 2,3-Dioxygenase (IDO) and Arginase-1 (ARG1) Expression and #MyeloidCell Infiltration in #ColorectalCancer" by Elomaa et al. used machine learning-based image analysis to detect and classify #cell and #tissue compartments in #QuPath. The cells were detected by using the cell detection function, and the #phenotype into 5 categories using the object classifier function. The 5 categories can be seen on the Modern Pathology cover below: #Monocytic cells (Sage Green), #Granulocytes (Pink), #MastCells (White), #TumorCells (Lime Green), and other cells (Orange) are shown in the figure (Mast Cells not shown in cover, but show in figure). https://lnkd.in/e_4me5AY

The Modern Pathology March Cover features images from a Review Article in our Special Issue "Next Generation #Pathology: Technological Advances in #AnatomicalPathology"; Edited by Liron Pantanowitz and Anil Parwani. The Review Article "High-Plex Assessment of Biomarkers in #Tumors" by Thazin N Aung, Katherine M. Bates, and David Rimm ? discusses methods of measuring #biomarkers in slide-mounted tissue samples ?detail the various high-plex methods that allow for the simultaneous assessment of multiple biomarkers in situ ?describes the impact of high-plex #biomarker assessment on the future of #anatomicpathology https://lnkd.in/gXJhDzjT