Mendelspod

We go behind the scenes today to see how CTO Chris Petersen and the team at Scientist.com is speeding up nearly every part of their business with AI. https://lnkd.in/grhkK4n8

In today's show, Dr. Jeffery Klco of St. Jude Children's Research Hospital says we've been misclassifying pediatric cancers for years. He says new methods such as long-read sequencing and methylation profiling hold promise for sharpening diagnostic tools and stratifying risk. https://lnkd.in/gUeCq8W3

“Cancer, at its root, is often a disease of disregulated identity. Cells that have lost their ability to regulate their own gene expression are primed for malignant transformation.” Dr. Aaron Viny of Columbia University talks about his journey from cancer patient to cancer researcher and how new spatial proteomics tools are offering insights into cancer epigenetics on today's show. https://lnkd.in/gm8aBGuy

We're out with our annual preview of the SynBioBeta conference with founder John Cumbers happening May 6-9 in San Jose. Topics: longevity, AI/bio, non-canonical amino acids, state of the market https://lnkd.in/gWhbde2D

Today on the show space genomics guy Christopher Mason from Weill Cornell Medical College is back with Simon Fredriksson of Pixelgen Technologies to talk about how cell proteomics offers a whole new modality for looking at inflammation (in space) and cancer. https://lnkd.in/gJxVQKTt

"DNA is still where it's at!" says PacBio CEO Christian Henry in our new interview. Coming off a "watershed" year, Henry says the company for the first time has "the full product line." https://lnkd.in/gzFpPriy

A new sequencing technology is born! On the show today explaining how the new Roche SBX system works and fits into the market for his annual State of Sequencing--er, Multi-Omics is sequencing guru Keith Robison. Covering also Illumina, PacBio, Stellaromics Inc., Cellanome and more . . . #sequencing #multiomics #nanopore https://lnkd.in/gnJBECJc

Happy International Women's Day! (Tomorrow) We're celebrating by featuring Mirna Ghemrawi, PhD discussing her journey into forensic genetics and research unlocking its future.  “The idea is that we can not only get human identification from DNA but also predict age, eye color, hair color, and even certain phenotypic traits,” she explains. “If this works, it could help narrow down family trees in genealogical investigations.” https://lnkd.in/gk2XWpSB

Return champion Hank Greely from Stanford is back on the show this time speaking urgently and unflinchingly about something we've all taken for granted: public funding for science. “Research is like fishing,” Greely explains. “You cast your net, and sometimes you catch something big, sometimes you don’t. But if you stop casting altogether, you’re guaranteed to catch nothing.” He argues that long-term investment in science is the only way to sustain real progress, even if individual studies don’t always yield immediate breakthroughs. https://lnkd.in/gckwfyXd

For decades, drug developers have struggled with so-called "undruggable" proteins—those regions of the proteome that evade traditional small molecules and antibodies. But Aikium Inc., led by Eswar I., could be changing the game. https://lnkd.in/gxU5bbQP