MedChemExpress LLC

?? March 27th (Thursday) ?? MedChemExpress LLC North America will be at Duke University for the show next Thursday. If you want to find out more about MCE, you can meet us at the show. We look forward to meeting you. ?? ? ?? Location: Trent Semans Center for Health Education, 6th Floor, 8 Searle Center Drive, Durham, NC 27710 ?? 11:00AM - 1:00PM ?? For More Information: https://lnkd.in/eXGE3XQC ? #LSE #lifesciences #molecules #research #smallmolecules #university #show #MedChemExpress

?? FDA Approves Mirdametinib: A New Hope for Neurofibromatosis Type 1 ?? ?? We are excited to announce that the FDA has approved Mirdametinib, a MEK kinase inhibitor, for the treatment of Neurofibromatosis Type 1 (NF1). This groundbreaking approval marks a significant advancement in the management of NF1, a genetic disorder characterized by the growth of tumors along nerves. ? Mirdametinib has shown promising results in clinical trials, demonstrating its ability to reduce tumor size and improve patient outcomes. This approval not only provides a new therapeutic option for patients but also highlights the importance of targeted therapies in addressing rare diseases. ?? For more detailed information: https://lnkd.in/g3UvaRtv ?? Join us in celebrating this milestone in NF1 research and the potential it holds for improving the lives of those affected by this condition! #Neurofibromatosis #Mirdametinib #FDAApproval #CancerResearch #TargetedTherapy

(English below) Nous sommes ravis de participer au congrès SFTCG ! Venez nous rencontrer sur notre stand pour découvrir nos solutions en thérapie cellulaire et génique. ???? ?? Cytokines & Facteurs de croissance ?? Milieux de culture cellulaire ?? Petites molécules pour la différenciation et l’expansion cellulaire ?? Réactifs pour l’édition génétique (CRISPR, etc.) ?? Retrouvez-nous sur place pour en discuter et profiter de nos offres exclusives ! à très bient?t ! ?? - We’re excited to be part of the SFTCG Congress! Visit our booth to explore our solutions for cell and gene therapy. ???? ?? Cytokines & Growth Factors ?? Cell Culture Media ?? Small Molecules for Differentiation & Expansion ?? Gene Editing Reagents (CRISPR, etc.) ?? Meet us on-site to discuss your research and take advantage of our exclusive offers! See you there! ?? #STCG #CellTherapy #GeneTherapy #SmallMolecules #LifeScience

?New Hope for Pediatric Brain Cancer! ??? ? A recent study in Cancer Cell has revealed potential therapeutic advancements targeting PDGFRA, a driver of high-grade glioma (HGG). Genomic analysis of 261 pediatric HGG cases conducted by researchers showed that 15% of the cases exhibited PDGFRA mutations or amplifications, indicating that PDGFRA is a potential therapeutic target. The researchers demonstrated that avapritinib, a selective PDGFRA/KIT inhibitor, can precisely target PDGFRA, penetrate the blood-brain barrier, and reduce tumor size in preclinical models. In early real-world data from 8 patients with recurrent PDGFRA-mutated HGG, 3 out of 7 evaluable cases showed good tolerability and radiographic response. ?? ? These findings suggest that avapritinib could be a potential breakthrough therapy for PDGFRA-driven HGG, translating laboratory insights into clinical impact. ?? ? https://lnkd.in/e5QH2aWn ? For more push, please follow #Twitter: https://lnkd.in/gntQ9qE7 ? Related Product Recommendation: #Avapritinib (BLU-285; https://lnkd.in/dDBnfP6y); ? ? #Dasatinib (BMS-354825; https://lnkd.in/gVCpkfr); ? #Axitinib (AG-013736; https://lnkd.in/gUjP4mef); ? #Crenolanib (CP-868596; https://lnkd.in/ep9GKuU2); ? #DTT (DL-dithiothreitol; rel-(2R,3R)-1,4-Dimercapto-2,3-butanediol; https://lnkd.in/gdPu_EXt); ? #Tween80 (Polysorbate 80; https://lnkd.in/dWJ2nhEW) ?? ? #CancerResearch #PrecisionMedicine #BrainCancer #PDGFRA #HGG #MCE #MedChemExpress

?? March 26th (Wednesday) ?? MedChemExpress LLC North America will be at #Yale #University - #Medical #School for the show next Wednesday. If you want to find out more about MedChemExpress, you can meet us at the show. We look forward to meeting you. ?? ? ?? Location: Omni New Haven Hotel at Yale, Mezzanine Level, 155 Temple Street, New Haven, CT 06510 ?? 11:00AM - 1:00PM ?? For More Information: https://lnkd.in/eXGE3XQC ? #LSE #lifesciences #molecules #research #smallmolecules #university #show #MedChemExpress

?? Who would have thought that what helps us remember fond childhood memories and complex mathematical formulas is a process similar to "inflammation" and DNA damage? ?? A recent study published in the prestigious journal Nature suggests that long-term memory storage relies on "brain inflammation" and DNA damage. Yes, you read that right! This biological response to adversity is actually a crucial tool for forging our memories. ? How do these two seemingly incongruous players – neural "inflammation" and DNA damage work together to shape our long-term memory storage? Let's explore this! #inflammation #DNAdamage #memory #TLR9

?? The MCE Webinar Will Soon Begin! Scan the code to join the discussion with Dr. Indrabahadur Singh from German Cancer Research Center (DKFZ). ?? 15 Years of Chromatin Factor Research: Lessons from HMGA Proteins and Future Horizons We hope you can join us! #HMGAProtein #HMGA #Webinar #Cancerresearch

?? Introducing MS8709: A Breakthrough in Cancer Treatment! ?? ?? We are thrilled to announce the emergence of MS8709, the first-in-class G9a/GLP PROTAC degrader, which is demonstrating a broad spectrum of anti-tumor potential. This innovative compound represents a significant advancement in targeted cancer therapy by harnessing the power of protein degradation to selectively eliminate oncogenic proteins. ? Preclinical studies have shown that MS8709 effectively inhibits tumor growth across various cancer types, offering new hope for patients with limited treatment options. As we continue to explore the therapeutic applications of this groundbreaking technology, we are excited about the possibilities it holds for improving patient outcomes. ?? For more detailed information: https://lnkd.in/gGupPFxR ?? Join us in the fight against cancer and stay tuned for more updates on this promising research! #CancerResearch #MS8709 #PROTAC #Oncology #Innovation #TargetedTherapy

(English below) ?? Retour sur notre participation au Congrès CEISAM 2025 ! ?? Nous avons eu le plaisir de participer au Congrès CEISAM, un événement qui met en lumière les savoir-faire et expertises du Laboratoire CEISAM (Chimie Et Interdisciplinarité, Synthèse, Analyse, Modélisation) de Nantes Université. Ce congrès a réuni des experts internationaux et mis en avant des posters présentés par de jeunes étudiants sur les dernières avancées dans le domaine. Un grand merci aux organisateurs pour leur accueil chaleureux ! CASSIR ?? Profitez de notre offre de printemps avec jusqu’à 20% de réduction sur des produits essentiels pour vos recherches ! En savoir plus ici : https://lnkd.in/e5b7KFMX - ?? Recap of our participation at the CEISAM Congress 2025! ?? We were pleased to participate in the CEISAM Congress, an event that highlights the expertise and skills of the CEISAM Laboratory (Chemistry and Interdisciplinarity, Synthesis, Analysis, Modeling). The congress brought together international experts and showcased posters presented by young students on the latest advancements in the field. A big thank you to the organizers for their warm welcome! ?? Take advantage of our spring offer with up to 20% off on essential products for your research! Learn more here: https://lnkd.in/e5b7KFMX

?? Drug repurposing, Infinite Innovation ?? Struggling with the high costs and long cycles of drug development? MedChemExpress LLC's Drug Repurposing Compound Library offers a brand-new solution!??? ? MedChemExpress Drug repurposing library contains thousands of compounds that are either already on the market or in clinical trials, helping you quickly identify safe and effective drug candidates, significantly reducing development risks!??? ?? Key Advantages: ?? Shorten development cycles? ?? Reduce development costs? ? Ensure drug safety #CompoundLibrary #DrugRepurposing #FDAApprovedDrugs #HighThroughputScreening #FDAApprovedDrugLibrary #Libraries #compound #drug