McCance Center for Brain Health at MGH

Congratulations to McCance Center Director??Dr. Rudolph Tanzi for being named to the Clarivate list of Highly Cited Researchers in 2024!?https://lnkd.in/gTbkFQpB

Kudos to McCance Center Director,?Dr. Rudolph Tanzi on his recent induction into the?National Academy of Medicine!?Hats off to Dr. Tanzi and all the inductees!?

McCance Center Medical Director Dr. Zeina Chemali shares her thoughts about increased #memory struggles in millennials in this Boston Globe Media piece: https://lnkd.in/dXrcH3gP

The McCance Center is hiring for two important roles! We are searching for A Senior Biostatistician/Research Associate and a Post-Doctoral Research Fellow in Brain Nutrition. To learn more about these exciting opportunities, visit:?https://bit.ly/McCanceBNL #CareerDevelopment??#Hiring?#brainresearch?

Find out more about the McCance Brain Care Score with this interactive version in the??The New York Times!

A?randomized three-year clinical trial?released today in JAMA Network Open?shows fish oil?high in omega-3 fatty acids?provides statistically significant benefit for those genetically predisposed to Alzheimer’s.??McCance Center’s? Dr. Gene Bowman is senior corresponding author. ? “This is the first dementia prevention trial to use modern prevention tools, such as a blood test and brain scan to identify not only people at high risk for dementia but also well suited to receive a specific nutritional intervention,” said?Gene Bowman, N.D., M.P.H., director of clinical trials and instructor of neurology at the McCance Center for Brain Health, Massachusetts General Hospital and Harvard Medical School. “The fact that neuronal integrity breakdown was slowed in people randomized to omega-3 treatment who are also at high?genetic?risk for Alzheimer’s disease is remarkable and warrants a larger clinical trial in more diverse populations in the future.” ? Bowman previously worked at OHSU, where?he secured funding to conduct the?clinical trial. https://lnkd.in/ezbtdUps

McCance Center Director Dr. Rudolph Tanzi and affiliated faculty Dmitry Prokopenko are co-authors on a new study in Nature describing a regional atlas of the aging human brain, providing insights into cellular vulnerability, response, and resilience to Alzheimer’s disease pathology. https://lnkd.in/gttsT-Ws #BrainHealth #Alzheimers

If you’re attending #AAIC24 in Philadelphia, McCance-affiliated faculty Edmarie Guzman-Velez, Ph.D., Dr. Rudolph Tanzi, Jonathan Rosand, and Dr. SteveArnold will have a poster on post-acute sequelae of COVID-19 on July 28th. Don't miss it! In addition, be sure to see the McCance Center poster on nutrient #biomarker assessment?in older adults at risk for dementia on June 29th?with Gene Bowman and Hira Shrestha!

Newly released research highlights a link between nutrition and dementia risk. The paper, Concurrent nutrient deficiencies are associated with dementia incidence ( https://lnkd.in/e4BZJnn9 ), found the combination of having 3 suboptimal blood nutrient concentrations places individuals, aged 50 and older, without a diagnosis of dementia at four times the risk of developing dementia, including Alzheimer’s disease. McCance Center Clinical Trials Unit and Brain Nutrition Laboratory Director, Dr. Gene Bowman, first identified this combination with colleagues in the large Multidomain Alzheimer Prevention Trial conducted in France. https://lnkd.in/eAn6pjf2 This new research study in the Framingham Heart Study is the first to confirm that this nutrient combination is also a major risk for dementia, including Alzheimer’s disease, in the US as well. Dr. Bowman participated in the PhD defense of the paper’s first author, Annick van Soest, a graduate student at Wageningen University in the Netherlands. Dr. Bowman weighs in on the new study, stating, “We are learning that the bloodstream can not only be a window into whether a person is developing plaque and tangles in the brain that cause the symptoms of Alzheimer’s disease, but importantly it also reflects the nutrients we consume that are most readily available to meet the brains demand for staying healthy and preventing plaque and tangle formation in the first place. In the future, we hope that brain care becomes a focus for people, and their healthcare practitioners, much earlier in life, and that this blood test of nutritional risk for cognitive decline is a cornerstone of those efforts so that modifiable risk factors can be identified and alleviated before it's too late to make a difference.”