Mass General Research Institute

In a new study, researchers from Massachusetts General Hospital and colleagues have uncovered a fascinating way that pancreatic cancer cells mimic viral behavior, which affects both the cancer cells and the surrounding healthy cells. The researchers found that certain repetitive RNA molecules in cancer cells communicate with nearby cells, altering their behavior. This "viral-like" communication seems to affect how cancer cells and support cells (called cancer-associated fibroblasts) behave. "This has given new insight into how tumors can disrupt normal cells and offers an opportunity to target these 'viruses' as future therapeutics," states David Ting, MD, author of the paper published in Cell by Cell Press. Read more: https://lnkd.in/ezV6U7_T The first author of the publication is Eunae You, PhD, from the Mass General Cancer Center. #CancerResearch #PancreaticCancer #RNA #TumorMicroenvironment #ScienceBreakthroughs

Congratulations to our very own Gary Ruvkun, PhD, on receiving the The Nobel Prize in medicine, along with co-recipient, Victor Ambros, PhD, from UMass Chan Medical School! The researchers received the prize for their discovery of microRNA and its role in post-transcriptional gene regulation. Understanding #MicroRNA allows researchers to prevent gene regulation from going awry, which can cause many diseases such as cancer, diabetes or autoimmunity. Read more: https://lnkd.in/g87VZ5Rz Mass General Brigham Massachusetts General Hospital

The Harris Orthopaedics Laboratory had lots of fun at the Cambridge Science Festival last Sunday! We demonstrated joint functions and shared our research focused on materials for joint replacements. Kids loved exploring unusual materials properties with our hands-on experiments with silly putty and the “messy” oobleck. Huge thanks to the Mass General Research Institute and the lab team for their great help for this successful and rewarding event! Ebru Oral, Orhun Muratoglu, Baiqi Pan, Zahra Eskandari, Maria Fernanda Serafim, Matheus Ferreira, Lu Yang, Keita Fujino https://lnkd.in/eVpyhVtY

Had a really fun time at the Cambridge Science Festival last week. We showed off a big DNA model with movable base pairs which kids could throw balls at to "damage", pretending to be sources of radiation. Clearly some shortcomings in this model ??, but it worked great to talk to kids at different ages about radiation and radiotherapy. Big thanks to the Mass General Research Institute and to Nicolò Cogno and Nils Peters for helping with an afternoon of chasing down loose photons (a.k.a foam balls)

A new AAP policy outlines ways pediatricians can safely prescribe opioids for acute pain management. Pediatrician Scott Hadland, lead author of the policy statement, breaks it all down and says that pediatricians should always provide naloxone when prescribing opioids. Learn more in AAP News: https://lnkd.in/e6ubCUiZ

"The way to develop cures to cancer is to be able to understand the cancer: know where it is, know how it's being changed by the treatment ... assess whether the new treatment is working quickly and efficiently." In this video, center director and all-around rock star Bruce Rosen, MD, PhD introduces viewers to the work done in the Martinos Center and the importance of that work for the advancement of human health.

Did you know that submitting an image from your research lab to the MGRI Image Awards is a great opportunity to share your science with the world? Well, now you know, so don't break our hearts by not submitting an image before the 10/31 deadline. All researchers at Mass General Brigham are welcome to participate! Read more: https://buff.ly/3Y4yh5x

In honor of #WomeninMedicineMonth, we took a moment to ask our healthcare professionals: “What drove you to pursue a career in medicine?” Their stories are a powerful reminder of the dedication, compassion and lasting impact they have on our patients every day.

We have all heard about daily exercise improving our health, but sometimes we might be too busy to exercise every day. However, in a new study, researchers found that the?'weekend warrior' pattern of exercise (concentrating most moderate-to-vigorous physical activity in one to two days during the week) was associated with similarly lower risks of diseases across 16 categories—from heart and digestive conditions to mental health and neurological illnesses. The study was published today in the American Heart Association's Circulation Journal by researchers from Mass General Brigham and colleagues. The findings indicate that concentrated physical activity patterns may be just as effective for disease prevention as patterns where exercise is spread out throughout the week. Read more about the study and how you can become a weekend warrior: https://lnkd.in/gc2P8vbM Authors included: Shinwan Kany, MD MSc, Mostafa Al-Alusi, MD, Joel R?m?, MD, PhD, James Pirruccello, MD, Timothy Churchill, MD, Steven Lubitz, MD, MPH, Mahnaz Maddah, PhD, J. Sawalla Guseh, II, MD, Patrick Ellinor, MD, PhD, and Shaan Khurshid, MD, MPH.

Today is World Cancer Research Day, and we asked our researchers about science-backed tips to reduce your risk of #cancer. From early screening to better diets, check out what they had to say: https://lnkd.in/gFB8GWD7 Featured researchers include Adjoa Anyane-Yeboa, MD MPH, Heming Wang, PhD, Daniel Sikavi, MD, Andrew Chan, MD, MPH, and Longgao Zhao, PhD. #cancer?#cancerresearch?#preventcancer?#diet?#sleep?#health