Marin Biologic Laboratories

Induced Proximity Strategies: Bridging Molecules for Advanced Therapeutics The concept of “induced proximity” is a key strategy in drug discovery, driving interactions between biomolecules or cells to achieve therapeutic effects. In immunotherapy, Antibody Recruiting Molecules (ARMs) and Covalent Immune Recruiters (CIRs) bring immune cells and targets together for cell killing. Link to the essay:https://lnkd.in/ga9HCGBy #indcuedproximity #protac #Cancertherapy #Immunotherapy #drugdiscovery Ken Steadman, PhD Seong Heon Kim Michael Kiebish, Ph.D. Maria-Dorothea Nastke Nitzan Shabek Dhanusha Nalawansha Georgios Mazis Gitte Husemoen Kate Ashton Weixian Deng Ryan Wurz Anh Tran Brian Lanman Jiansong Xie Robert Guenette shiqian li Rajiv Kapoor Felipe de Sousa e Melo Zhenyi Liu Ming-Chi Tsai Soumitra Ghosh, PhD Jessica Lawrence Sarah Church Baris Bingol S?ren Warming

Proteolysis-Targeting Vaccines (PROTAVs): A Novel Approach in Cancer Immunotherapy PROTAVs, which are built on the principles of proteolysis-targeting chimeras (PROTACs), enhance tumor antigen processing and presentation within antigen-presenting cells (APCs), aiming to elicit strong CD8+ T cell responses. Details: https://lnkd.in/gRQc7hGJ #PROTAC #TargetedProteinDegradation #LYTAC #MolecularGlues #GlueTAC#bioPROTAC #AUTAC #AbTAC #Cancertherapy #Immunotherapy #drugdiscovery Ken Steadman, PhD Seong Heon Kim Michael Kiebish, Ph.D. Maria-Dorothea Nastke Nitzan Shabek Dhanusha Nalawansha Georgios Mazis Gitte Husemoen Kate Ashton Weixian Deng Ryan Wurz Anh Tran Brian Lanman Jiansong Xie Robert Guenette shiqian li Rajiv Kapoor Felipe de Sousa e Melo Zhenyi Liu Ming-Chi Tsai Soumitra Ghosh, Ph.D. Jessica Lawrence Baris Bingol S?ren Warming

What is only interferon in the female reproductive tract? Type-I interferons?(IFN) are essential for?inflammation,?immunoregulation, tumor cells recognition, and?T-cell?responses.?They?include?IFN-α and IFN-β that stimulate anti-viral responses,?and are active against?tumors.?IFN-α acts as a?pyrogenic?factor, causing fever, by binding to?opioid receptors?and eliciting the release of?prostaglandin-E2?(PGE2). IFN-α also reduces pain, acting as an?analgesic. Use In Cancer IFNα made by several companies has been approved by the US Food and Drug Administration (FDA) for cancer. Use In Multiple Sclerosis There are four FDA approved variants of IFN-β used as a treatment for multiple sclerosis.?They reduce brain lesions and reduce T cell infiltration into the brain. Type II, IFN-g IFN-g is critical for?immunity?against?viral,?bacterial?and?protozoan infections. ?It induces?IgG?isotype switching?in?B cells; induces CD8+?cytotoxic T cell activation, and activates?macrophages.?Aberrant IFN-g expression is associated with a number of?autoinflammatory?and?autoimmune diseases. Type III interferons (IFN-λs)?are similar to Type I IFNs but target mucosal epithelial cells locally and protect against viruses. However, they are associated with the pathogenesis of several autoimmune rheumatic diseases. IFNe (epsilon) is apparently only expressed in the female reproductive tract, constitutively, and participates in anti-microbial defense.?IFNε is also an intrinsic tumor suppressor that prevent the accumulation and activation of myeloid-derived suppressor cells and regulatory T cells. Interferon-ε is a tumour suppressor and restricts ovarian cancer, by Marks et al., Nature 620: p 1063, 2023.

Break-Throughs in HIV therapy :?Zombie virus, Block infection, New drug Zombie virus. ?An HIV virus was engineered that infects and replicates in host cells and competes with wild type. ?Being a minimal virus, lacking many of the wild type genes, it also outgrows wild type virus.?A proof of concept?was conducted in a related monkey model using Simian Immunodeficiency Virus with the gene for HIV surface protein, HSIV.?After 30 weeks of coinfection, 5 of 6 zombie-treated monkeys were healthy and their levels of SHIV had dropped by a factor of 105, from a peak of 100.000,000 copies/mL blood to 10,000/ml.?In contrast, 3 of 4 control animals were so sick at 16 weeks that they had to be euthanized (Science 385: 586 and 622, 2024). Block infection.?Bone marrow transplantation (BMT) is a complete replacement of a patient's blood cells with donor cells.?This has been an effective therapeutic regime for patients with leukemia or lymphoma. ?This was applied to an HIV patient with cancer using bone marrow cells of a donor with a mutation in both alleles of CCR5, an HIV receptor on the surface of T lymphocytes. ?As first reported in Nature (vol 632, pg 235, 2024), this resulted in complete elimination of infection, as the mutation prevents infections.??Since then, 5 more patients have been apparently cured by BMT using homozygous mutant CCR5 cells.?Now a seventh HIV patient has been reported “cured”, for six years after stopping taking antiretroviral therapy, but using donor cells that had only one allele of mutant CCR5.?A single copy of the CCR5 protein lowers the infectivity of HIV. ?BMT requires matching donor and recipient for other genes, so the availability of donors with one mutant CCR5 allele greatly expands the pool of potential donors for HIV patients. New Drug, lenacapavir for preexposure Anti viral medicines have been generally unavailable until very recently.?Lonely idoxuridine was approved for some herpes virus?infections?in 1962.?Acyclovir?was approved for chickenpox and herpes zoster in 1981.?Gilead Sciences has been especially active?in getting?drugs approved for hepatitis and HIV.?This August 2024, Gilead announced?that a twice-yearly?injection of their lenacapavir as a preexposure?prophylaxis resulted?in no infections in 2000 at risk?women over one year and similar results in men (review article by K.Kupferschmidt, Science 385: 478,2024). The therapy is seen as a great improvement in protection due to stigma and compliance in a daily pill regime. Help with your project Marin Biologic Laboratories can help your next step to complete your company goals !! ● Develop, GMP validate,?perform potency bioassays ● Develop, GLP validate, perform ELISAs. RIA ● AAV or plasmid transfect with Flow cytometry or ELISA output ● Quantitative PCR for gene transfer, gene expression ● Enzyme assay ● Radioactivity assays, 7 isotopes available ● Mixed Lymphocyte Reaction (MLR) for antigenicity test www.marinbio.com, [email protected], 414 883-8000

Breakthroughs in Antibody-Drug Conjugates (ADCs) Highlighted from ASCO 2024 Abstracts Link to the news article: https://lnkd.in/gZu2Hz2r #ADC #antibodydrugconjugate #peptidedrugconjugate #antibody #cancertherapy #immunotherapyRong Shi Halei Zhai Yongjian Wu, PhD Steve Alley Daniel Golec Ligia Emanuela Sega Kellogg Parsons, MD, MHS, FACS Alison Betts Faye (Zufei) Zhang Frank Christian Dr. Richard Hsuan Ping Chang Jeff Kearns Jianzhong Wen Michael Z. Liao, PhD, MLS Niyanta Kumar Rajeev Menon Sandhya Girish Seema K. Venkatesh Pilla Reddy Xiaogang Han Yuting Wang, Ph.D Jitender Nandal, PhD Pallavi Sinha Roy

Great future and current Targeted Protein Degradation and PROTAC

Cellular Death That Can Cure: Exploring Immunogenic Cell Death (ICD) in Cancer Immunotherapy Link to the scientific essay: https://lnkd.in/gUDMaScZ #cancertherapy #immunotherapy #panoptosis #panoptosome #apoptosis #celldeath #drugdiscovery #caspase #pyroptosis #necrosis #immunogeniccelldeath Carles Martínez-Romero, Ph.D. Sachin Surwase, PhD Takahiro YAMAZAKI Abraham Lin Dhiraj Kumar Amelia Z. Niranjan Yanamandra MSc. Ph.D Louis Boon Miguel Reina-Campos Attila Seyhan, PhD Maria (Masha) Babak, PhD Taronish Dubash Tania L?ve Aaes Anthony Bajoras Luis A. Aguilar

Very informative and well documented discussion of TPD and PROTAC.

Targeted Protein Degradation/PROTAC for Innovative Drug Development: Current Trends and Future Prospects. Click here to read the scientific essay: https://lnkd.in/gcpnzb9t ? #PROTAC #TargetedProteinDegradation #LYTAC #MolecularGlues #GlueTAC #bioPROTAC #AUTAC #AbTAC #Cancertherapy #Immunotherapy #drugdiscovery Ken Steadman, PhD Seong Heon Kim Michael Kiebish, Ph.D. Maria-Dorothea Nastke Nitzan Shabek?Dhanusha Nalawansha Georgios Mazis Gitte Husemoen Kate Ashton Weixian Deng?Ryan Wurz?Anh Tran Brian Lanman Jiansong Xie Robert Guenette shiqian li? Christopher Smith?Rajiv Kapoor suresh Archunan??Felipe de Sousa e Melo Zhenyi Liu?Ming-Chi Tsai Soumitra Ghosh, PhD Jessica Lawrence Sarah Chu?Baris Bingol S?ren Warming

@MarinBio can help you with drug screening, mechanism of action, GMP potency bioassay, develop novel ELISA, etc.