LyoHUB

As we prepare to celebrate Thanksgiving this week, we share our thankfulness for the dedication and commitment of our LyoHUB members who are working together to advance the science and technology of #lyophilization. IMA Group PfizerThe Janssen Pharmaceutical Companies of Johnson & Johnson Millrock TechnologyINFICON ATS Scientific Products Simtra BioPharma Solutions AbbVie Roche Siemens Fresenius Kabi Bristol Myers Squibb OPTIMA packaging group Amgen EMD Serono, Inc. AstraZeneca Evonik Daiichi Sankyo US Corning Incorporated Sanofi Merck Elanco Jazz Pharmaceuticals Metrohm Physical Sciences Inc. Regeneron West Pharmaceutical Services Tempris GmbH Fluid Air NIBRT National Institute for Bioprocessing Research and Training Stevanato Group Eli Lilly and Company Ansys Nipro Corporation - Global Zoetis DFE Pharma

Great to have Nipro as part of LyoHUB! Looking forward to collaborating!

Exceptional study on the role of phase separation and local mobility in stabilizing lyophilized IgG2 formulation just published in AAPS PharmSciTech. The utility of employing solid-state NMR (SSNMR) to assess parameters governing the stability of a lyophilized IgG2 protein was the focus of the present work. Specifically, the interaction between the sugar stabilizer (sucrose) and protein component was measured using SSNMR and compared to physical and chemical stability data obtained from thermally stressed samples.?1H T1?and?1H T1??relaxation times were measured by SSMNR for 5 different formulation conditions, and the resultant values were used to examine local mobility and phase separation, respectively. From the SSNMR measurements, it was found local mobility decreased as the sucrose to protein weight ratio increased. The decrease in local mobility corresponded to an increase in storage stability (both chemical and physical) of the lyophilized solids up to a critical weight ratio of sucrose to protein. Additionally,?1H T1??measurements obtained on formulations having higher protein to sucrose weight ratios indicated phase separation of the protein and sucrose phases was occurring, at least on a small scale. Along with an increase in local mobility, phase separation in these specific formulations is thought to have played a role in their decreased storage stability in the solid state. Ashley Lay-Fortenbery,?@Ryan E Holcomb,?Charles Henry,?@Mark C Manning?&?Eric Munson Purdue University Colorado State University American Association of Pharmaceutical Scientists (AAPS) | @aapscomms Daniel Davis, Ph.D., PharmD Johana Suh Claudio Salomon Michael Repka QI (Tony) ZHOU Sanyog Jain Link: https://rdcu.be/d00oy

Interesting new paper on the use of solid-state NMR #spectroscopy and UV/VIS diffuse reflectance for determining #solid-state acidity of #lyophilized #trehalose. Congratulations to authors, Ashley Lay-Fortenbery Xiaoda Yuan Dominik Heger Luká? Vesely Yongchao SuEric Munson #SSNMR #spectroscopy #lyophilization #freezedry #pharmaresearch #pharmaceuticalmanufacturing

Rising College Sophomores and Juniors - apply today for a PAID, one-week, hands-on training opportunity at Purdue University Indianapolis location to learn about #biopharmaceuticalmanufacturing and #career opportunities in this area. Visit Eli Lilly and Company, Simtra BioPharma Solutions to get a behind-the-scenes view of #pharmaceuticalmanufacturing and receive hands-on training at Purdue University Ivy Tech Community College Bloomington Ivy Tech Community College Indianapolis. Visit https://lnkd.in/d8VgxSX9 to learn more and apply! #NIIMBLeXperience2025 #biopharma #biopharmaceuticals #workforcedevelopment

Purdue University is well represented today at the ASTM International's #Healthcare #Innovation Workshop in Orlando, identifying gaps and opportunities in this space. Great to brainstorm with ASTM International President and Purdue University Mechanical Engineering alumni, Andy Kireta and John Logar the Chair of ASTM International E55 Committee on #Pharmaceutical and #Biopharmaceutical Products with Jennifer Gray, Secretary of E55

Informative presentation by Jyothi Rangineni, Senior Process Process Scientist at Fluid Air comparing the drying processes: Lyophilization and Electrostatic Drying using BSA @Nataliebruce @stevenail @Tarunikachavva @katherinebuzecky @alinaalexeenko #lyophilization #freezedry #electrostaticdrying #spraydrying #pharmaresearch #pharmaceuticalmanufacturing

A big congratulations to Alina Alexeenko who was recently named the Reilly Professor for the School of Aeronautics and Astronautics, Purdue University and Purdue University Davidson School of Chemical Engineering in recognition of her dedicated leadership as director of LyoHUB and co-director of the William D. and Sherry L. Young Institute for Advanced Manufacturing of Pharmaceuticals, as well as for impressive research in the areas of #computational and experimental #rarefiedgasdynamics, #heatandmasstransfer engineering in application to #inspacepropulsion, #vacuumtechnology and #pharmaceuticalmanufacturing. Congratulations, Dr. Alexeenko on this well-deserved honor! https://lnkd.in/gQ7Tc_2i Alina Alexeenko Dimitrios Peroulis Arvind Raman Purdue University College of Engineering Purdue University Purdue Office of Professional Practice Purdue University College of Pharmacy

Dive into Lyo101, #LyoHUB’s FREE online course that walks you through the essentials of #lyophilization! With the Lyo101 course: ?? (8) 20-minute learning modules ? Comprehension quizzes with each module ? Self-paced ?Virtual lab exercise of lyophilized cycle An official LinkedIn Certification is available upon successful completion to boost your profile. Join a community of over 950 learners who have taken this course to explore the fundamentals of lyophilization. Enroll now and start your journey. https://lnkd.in/gPBfX9uR #FreezeDrying #Lyophilization #LyoHUB #FreeCourse #PharmaEducation #Biotech #JoinUs

Zack Cox, a Pharma Professional, recently completed LyoHUB's “#FreezeDrying: Principles and Practice” online course. He found the no-pressure quizzes and modules on cake defects especially helpful, making the course both engaging and highly applicable to his work. Ready to master the essentials of freeze drying? ?? Check out LyoHUB's new course, "Freeze Drying: Principles and Practice"! https://lnkd.in/g5gXVxu3 #Lyophilization #FreezeDrying #PharmaTech #LyoHUB #PharmaceuticalManufacturing #DryingTechnologies