Lifespan Research Institute

?? Reminder: NextMed Health 2025 is just around the corner! I’ll be there from March 30 to April 2! ?? Be part of this amazing event where we’ll dive deep into the future of health and medicine. Let’s learn, innovate and create unforgettable moments together! ?? Find out more: https://lnkd.in/gX7v55xi #NextMedHealth

At the end of 2022, YOU voted to tell us which aspect of aging research should take priority. The choice was clear: extracellular matrix repair. Now, thanks to your feedback, LRI is funding innovative research at the University of Sydney, where Dr. Ziyu Wang’s team is developing targeted nanodevices to restore stiffened, aging arteries by repairing damaged elastin, a key protein that keeps arteries flexible. Arterial stiffening is a major driver of heart disease and hypertension. By addressing this root cause of vascular aging, this research could significantly lower the risk of heart attacks, strokes, kidney disease, and other related pathologies, helping people live longer, healthier lives. Learn more: https://lnkd.in/dm_TiMhi

A new preprint from the Sharma Lab at LRI presents key findings on senescence markers. One of the biggest challenges in developing senolytic therapies is specificity. While many markers of senescence have been identified, none are entirely reliable because they can also appear in healthy cells under certain conditions. This overlap makes it difficult to distinguish senescent cells in aging and diseased tissues and to target them for destruction without affecting healthy cells. A new preprint from Dr. Amit Sharma and his team at Lifespan Research Institute identifies a surface protein that could serve as both a universal and specific marker for senescent cells, including those from tissues in organisms. The team also successfully targeted this protein with weaponized antibodies, selectively eliminating senescent cells while sparing healthy ones. If confirmed, in other disease models and tissue, this discovery could provide scientists with a powerful tool for conducting more accurate and reliable research on cellular senescence in aging and disease. It could also pave the way for the development of highly effective senolytic therapies, potentially addressing a major factor in aging and advancing longevity research. Learn more: https://ow.ly/gJTK50Vit1r By: Arkadi Mazin #longevity #senescence #aging #preprint

Eating an unhealthy #diet, even in moderation, may have unintended consequences. A new study from Hospital of the university of Tübingen, German Center for Diabetes Research (Deutsches Zentrum für Diabetesforschung, DZD), and Helmholtz Munich shows that short-term overeating alters brain insulin sensitivity—potentially affecting metabolism and weight regulation. Led by Dr. Stephanie Kullmann and co-authored by Dr. Andreas Birkenfeld, this research highlights how even brief dietary changes can impact brain function. Learn more: https://lnkd.in/ef7CXmgp By: Arkadi Mazin

Step Up for Parkinson’s! Support Parkinson’s research by participating in Moving Day San Jose, a walk hosted by the Parkinson's Foundation! This event is an opportunity to raise awareness and make a difference for those affected by this disease. You can: --> Walk as an individual or with a team --> Qualify for rewards while supporting a great cause --> Help shine a light on Parkinson’s and fund critical research Learn more and sign up today: https://lnkd.in/dnPrRvVP #Parkinsons

Lifespan Research Institute bids a fond farewell to Bill Liao, one of our longest-serving board members, as he embarks on a new chapter as Investor Director for the Ki Tua Fund at Cyclarity Therapeutics. Thank you, Bill, for your commitment, passion, and the countless hours you have dedicated to supporting our organization. We deeply appreciate your contributions and wish you success in the next phase of your journey!

February is packed with celebrations like Super Bowl Sunday, Valentine’s Day, and Galentine’s Day. But did you know it’s also the month when the UN recognizes Women and Girls in Science worldwide? This year’s theme for International Day of Women and Girls in Science is Unpacking STEM Careers: Her Voice in Science. I think it’s a powerful call to action for business leaders and many more changemakers to listen, uplift, and take action to ensure that every voice in STEM is heard and valued. Science, Technology, Engineering, and Math (STEM)* are shaping our world, from AI and climate tech to medicine and space exploration. But too often, the voices of women, girls, and nonbinary people in these fields go unheard. How many discoveries have been missed? How many breakthroughs could have been accelerated with more diverse perspectives? Diversity, equity, and inclusion is not just about filling gaps—it’s about honoring the need for every individual to be seen, heard, and respected in their field. Even though there’s a lot of noise around DEI right now, I know one thing for sure. The world’s most pressing challenges—climate change, food security, health crises—demand the brightest minds and the full spectrum of talent, innovation, and creativity. From every background. This belief is why I’m committed to amplifying voices in STEM. Whether in the lab, boardroom, classroom, or virtual space, we simply need all hands on deck to build an inclusive, sustainable, and ethical future. So today, I ask you: How can we better support women and girls in STEM? Whether through mentorship, policy changes, speaking up, or simply sharing stories of women in STEM in your digital platforms, actions both big and small can make a difference. ?? Make sure to share this post and the links below in order to keep the conversation going! And if you haven’t yet, please subscribe to my Be Voracious newsletter on Substack to get insights straight to your inbox.? PS I’ll be dropping links in the comments to articles and videos showcasing more voices of women in STEM. ?? Sharing photos of some amazing women and girls in STEM that I’ve had the incredible opportunity to work with. Unable to tag each one, but big cheers to all these voices making the world a better place! *You may also have seen the acronyms STEMM (+Medicine) and STEAM (+Art), which expand this constellation of awesome fields that make the world better! #womenandgirlsinscience #womeninstem #womeninstemm #womeninsteam #diversity #equity #inclusion

How close are we to breakthroughs in treating age-related diseases? How are human clinical trials progressing? What new advancements are emerging? Lifespan.io's Rejuvenation Roadmap tracks the most promising research and technologies in longevity science, keeping you up to date on where we are, and what’s ahead. Check it out here: https://lnkd.in/e_sHVRF

?????? ???????? ?????? ?????????????????? ???????????????? ???????? ????????! ?????? ???????????? ?????????????? ?????????????????? ???? ?????????? ???????? ???????? ?? ???????? ?????????????????? ??????????????, “???????????????????? ??????????????????: ???????? ???????????????? ???? ????????????,” ???? ???????????????? ????, ????????, ???? ??:???? ???? ?????? ???? ???????????? ?????????????? ??????. Notable witnesses include: Eric Verdin, MD – President and CEO, Buck Institute for Research on Aging Sarah C. Nosal, MD, FAAFP – Physician, President-Elect, American Academy of Family Physicians Dan Buettner – Founder, Blue Zones Rhonda Patrick, PhD – Founder, FoundMyFitness Tune in this Wednesday to watch the livestream here: Senate Aging Committee Hearing (https://lnkd.in/g77YG6C9).

?? LAST CHANCE TO SIGN! ?? The Senate Special Committee on Aging is meeting next week, and this is your final opportunity to add your name to our Open Letter urging the White House Conference on Aging to be a priority! ?? Your voice matters! Sign now and share your story to make an impact. ?? Sign here: https://lnkd.in/gUznw5D5 Let’s make sure this issue gets the attention it deserves!