Lifespan.io Longevity News

Not all senescent cells are purely harmful. Some may hold the key to controlling #inflammation. New research uncovers how a core biomarker of senescence could play a protective role. https://lnkd.in/dN4PPQmf By: Josh Conway

A study testing a hypothalamic neuropeptide therapy improved multiple #aging biomarkers in mice, suggesting that targeting key brain regions may have widespread #longevity benefits. https://lnkd.in/dsfQxS-e By: Anna Drangowska-Way, PhD

Elamipretide, a well-investigated mitochondrial-targeting peptide, is making new waves. Recently, Dr. Vadim Gladyshev’s team has published new research highlighting its powerful effects on mitochondrial pathways and its potential to reverse frailty in mice. https://ow.ly/i2Y550Vjf18 By: Josh Conway

A new preprint from the Sharma Lab at LRI presents key findings on senescence markers. One of the biggest challenges in developing senolytic therapies is specificity. While many markers of senescence have been identified, none are entirely reliable because they can also appear in healthy cells under certain conditions. This overlap makes it difficult to distinguish senescent cells in aging and diseased tissues and to target them for destruction without affecting healthy cells. A new preprint from Dr. Amit Sharma and his team at Lifespan Research Institute identifies a surface protein that could serve as both a universal and specific marker for senescent cells, including those from tissues in organisms. The team also successfully targeted this protein with weaponized antibodies, selectively eliminating senescent cells while sparing healthy ones. If confirmed, in other disease models and tissue, this discovery could provide scientists with a powerful tool for conducting more accurate and reliable research on cellular senescence in aging and disease. It could also pave the way for the development of highly effective senolytic therapies, potentially addressing a major factor in aging and advancing longevity research. Learn more: https://ow.ly/gJTK50Vit1r By: Arkadi Mazin #longevity #senescence #aging #preprint

Interested in the field of longevity? LongX | Longevity Xplorer is launching the 2nd edition of their Xplore program - a remote fellowship helping early career seekers break into #longevity biotech. Applications close on March 31st, so apply before time runs out! Learn more: https://ow.ly/jKtM50Viqtn

Researchers identify a “distinct phenotype of neurological impairment” in a new study, suggesting that cellular senescence may affect cognitive flexibility in some male mice. This could open new doors for treating neurological impairments—beyond #Alzheimers— through #senolytics. Learn more: https://lnkd.in/dVtdVa-Q By: Josh Conway

Aging and disease aren’t just shaped by our genes—they’re deeply influenced by our environment. A new paper by Tina Woods, Professor David Furman, and Professor ?? Nicola Palmarini, experts from Buck Institute for Research on Aging, UK National Innovation Centre for Ageing, and the International Institute of Longevity, explores the impact of the exposome on #health. As discussions continue at the Exposome Moonshot Forum, these insights could help redefine preventative healthcare. Learn more: https://lnkd.in/eqa6PCMx

Life expectancy across #europe has shifted in surprising ways, with some regions thriving while others face new health challenges. Advances in medicine and public health have driven progress, but economic and social factors continue to shape #longevity trends. Explore the latest data and what it reveals about #aging in Europe: https://ow.ly/2zI050VgAvh By: Anna Drangowska-Way, PhD

Do bigger animals with more cells get #cancer more often? A new study from the University of Reading, University College London, and Johns Hopkins Medicine, led by Professor Chris Venditti and Dr. Joanna Baker, challenges conventional thinking on Peto’s Paradox: https://lnkd.in/eaQGdBjj By: Arkadi Mazin #longevity

A widely used diabetes drug is showing promise for more than just blood sugar control. New research suggests it may also target key hallmarks of #aging, potentially improving #health and #longevity. Learn more about this exciting development: https://lnkd.in/dPHzqy6Z By: Josh Conway #supplements