Lado Healing Institute

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It’s been a while since I’ve completed my Fifth Pathway Program at Mount Sinai School of Medicine of New York University, but I wanted to share this update with everyone.

It’s been a while since I’ve completed my Medical at Universidad del Noreste, but I wanted to share this update with everyone.

It’s been a while since I’ve completed my Internship at Baylor College of Medicine, but I wanted to share this update with everyone.

It’s been a while since I’ve completed my Residency Program at The University of Texas Health Science Center at Houston (UTHealth Houston), but I wanted to share this update with everyone.

It’s been a while since I’ve completed my Bachelor of Pharmacy (B.Pharm.) at Long Island University, Brooklyn Campus, but I wanted to share this update with everyone.

The University of Surrey study highlights how extreme environmental stressors, such as living in war-torn areas, can lead to measurable biological changes in DNA. This finding aligns with epigenetics, which studies how environmental factors influence gene expression without altering DNA sequences. The Case: Stress-Induced DNA Alteration 1. Epigenetic Modifications Chronic stress activates epigenetic mechanisms like DNA methylation, histone modification, and microRNA expression, influencing stress responses, immune function, and inflammation. 2. Oxidative Stress and DNA Damage Stressful experiences increase reactive oxygen species (ROS), leading to oxidative stress that damages DNA. This stress activates pathways related to chronic inflammation and DNA repair mechanisms. 3. Visual and Sensory Systems Constant exposure to traumatic scenes in war amplifies stress responses via the hypothalamic-pituitary-adrenal (HPA) axis. This systemic stress releases cortisol, influencing DNA integrity through oxidative stress. 4. Impacts on Children Syrian refugee children in the study may face lifelong health challenges, including vulnerability to chronic diseases and mental health disorders, due to these DNA changes. Supporting Studies 1. Oxidative Stress and PTSD A Molecular Psychiatry (2015) study found higher oxidative DNA damage in individuals with PTSD, showing how trauma affects DNA repair. (Source: DOI:10.1038/mp.2015.44) 2. Epigenetic Changes in Survivors Research on Holocaust survivors revealed epigenetic modifications in stress-related genes, illustrating trauma’s impact on DNA and its potential heritability. (Source: Yehuda et al., Biological Psychiatry, 2016) 3. T

These are some thought-provoking ideas about GLP-1 (glucagon-like peptide-1), especially regarding its role in addiction and its interaction with the brain’s reward centers. The potential of GLP-1 in treating addiction disorders stems from its capacity to regulate dopamine release and influence reward pathways, making it a powerful peptide. It’s fascinating to consider that this molecule, which originates in the gut, plays such a significant role in brain function and behavior. The question of why we now rely on exogenous GLP-1 analogs is critical. It raises deeper inquiries into what has changed in the gut’s ability to produce or utilize GLP-1 effectively. Factors such as diet, chronic inflammation, gut microbiome disruption, and environmental toxins might contribute to this dysfunction. The industrialization of food, with increased consumption of ultra-processed foods and reduced dietary fiber, could be one culprit. These dietary shifts might impair the health of enteroendocrine cells, which are responsible for producing GLP-1, and alter the gut-brain axis. Another aspect to consider is whether the increased prevalence of insulin resistance and metabolic disorders in the population affects GLP-1 production or signaling. These conditions could create a state where the gut is unable to respond to normal stimuli, necessitating pharmacological interventions to mimic what was once a natural process. Ultimately, this highlights the importance of exploring preventative measures to restore gut function and enhance the body’s natural GLP-1 production. Future research might focus on identifying dietary, microbial, or other environmental interventions that could restore balance

Today, I want to dive into a topic that often flies under the radar but deserves much more attention: the impact of the food industry on our metabolic health. Have you ever wondered if something in our food system might be subtly interfering with our body’s natural processes, especially in how we perceive fullness or process glucose? Lately, with the rise of medications like Mounjaro and other GLP-1 receptor agonists that accelerate satiety, it seems like this issue is becoming even more apparent. These medications work by helping people feel full faster—so why is it that without them, many of us seem to overeat or fail to feel satiated? This led me to a critical question: Are there additives or food processing methods in our everyday diets that could be interfering with our natural hunger and fullness signals? Recent studies have shed light on this concern: 1. Food Additives and the Gut Microbiome: ? Research has shown that certain food additives may alter the gut microbiome, which plays a crucial role in regulating neurotransmitters like serotonin and dopamine. These neurotransmitters not only affect mood but also influence appetite and satiety (Wang et al., 2024). ? For instance, one study revealed that imbalances in gut microbiota caused by food additives can reduce the production of GABA, a neurotransmitter associated with calming the nervous system and regulating appetite (Hasaniani et al., 2024). 2. Neurotransmitter Disruption: ? Altered gut bacteria due to dietary additives can impact the gut-brain axis, leading to changes in neurotransmitter production. This disruption may weaken natural satiety cues, encouraging overeating (Farhan and Faisal, 2024). 3. Bioactive Interventions: ? On a positive note, bioactive compounds like probiotics and certain prebiotics can counteract these effects. Studies highlight that supplements like Bifidobacterium breve improved neurotransmitter balance and reduced stress-related overeating (Wang et al., 2024). 4. Food Processing vs. Natural Nutrition: ? Highly processed foods tend to lack the fiber and nutrients necessary to sustain a healthy gut microbiome. Countries with stricter food processing regulations, like many in Europe, report fewer cases of metabolic syndrome and obesity, potentially tied to these differences (Shennon et al., 2024). These findings underscore the importance of diet in regulating not only physical health but also the neurochemical balance that influences eating behavior. So, here’s the question we should all be asking: Could our food system—particularly the use of additives and ultra-processing—be amplifying the very problems that new medications like GLP-1 agonists aim to solve? Let’s open up this dialogue. What’s your take? Could the way we process food today be part of a larger problem we’re just beginning to understand? Share your thoughts below!

PART III The Elephant in the Room: Inflammation and the Uncomfortable Truths of Modern Medicine Closing Thoughts Whether we like it or not, powerful changes are coming. With the potential leadership of a new Dept of Health and Human Services administration under Robert F. Kennedy Jr., there will undoubtedly be significant pushback as industries and systems are challenged. But it doesn’t have to be that way. This is an incredible opportunity for growth, not just for the food and pharmaceutical industries but for society as a whole. By addressing the critical issues of inflammation, oxidative stress, and the underlying physiological pathways, we have a chance to innovate and create a healthier future. These growth opportunities are literally under our noses, but we fail to see them until we connect the dots. The evidence is there—waiting to be explored, understood, and applied. This idea of connecting the dots is critical and could be a whole separate discussion, one that I plan to address with more scientific rationale in a future journal article. I don’t enjoy politics, but it is a reality we all must face as we move into a new era of leadership and accountability. These changes, if approached with collaboration and open-mindedness, could provide unprecedented growth opportunities across industries while improving the health and well-being of millions. Let’s put aside our differences, work together, and embrace this moment as a chance to drive progress. The future isn’t just about survival—it’s about thriving in a way that benefits everyone. The time to act is now. As always, the adventure does not end here. Stay tuned, keep your eyes open, and approach these topics with an open mind. After all, as the saying goes, all roads lead to Rome. The path forward may be complex, but it holds the promise of remarkable discoveries and meaningful progress for all.