KCAS Bio - Philadelphia

A #FlowCytometry #BackbonePanel is?a set of #antibodies that can be used as a starting point for identifying #CellTypes, and then supplemented with additional markers. On the most recent episode of #TheConversationalFlow #podcast, our hosts, Brian Wile, PhD and Adam C., spend some time together as they answer questions about #BackbonePanels like “What type of changes should be considered for a backbone panel?”, “What are the advantages to backbone panels for translational teams?”, “What should one be careful of when modifying a backbone panel?”, “Should you use a backbone panel for a translational research program?”, and many others. Click here to watch the entire episode: https://lnkd.in/gUJvw8M6

When it comes to understanding immune cell functionality, intracellular cytokine staining (ICS) assays provide a window into cellular responses that are essential for advancing immunotherapies and vaccines. KCAS Bio's latest blog by Heather Evans, PhD, explains how these assays, paired with flow cytometry, enable precise assessment of cytokine production, offering valuable insights into immune cell activity. By honing in on single-cell data, ICS assays help researchers uncover functional immune responses, supporting critical therapeutic and diagnostic breakthroughs. Find out how this approach strengthens research and development for life-saving treatments. Click here to read more: https://lnkd.in/gB8cXw75 Discover the science behind immune functionality with ICS assays. #FlowCytometry #ImmuneFunctionality #CytokineBiology #BioanalyticalScience #Immunotherapy

Looking for solutions on immunophenotyping, ROA, PK, ADA, cytokine storm monitoring? Our team at KCAS Bio is here to discuss how we could help accelerate your programs! We are also excited to share our global flow cytometry service in Lyon (Europe), Philadelphia (US), and Australia! Come say hello to me and my colleagues Brian Wile, PhD and Cecile Durand at the Festival of Biologics ???? KCAS Bio - Philadelphia KCAS Bio - Lyon #biologics #bioanalysis #biomarkers

Next week our team will be attending the Festival of Biologics 2024 in Basel. If you're developing drugs in vaccines, antibodies, or cell and gene therapy, reach out to schedule a meeting and explore how we can help drive your biologic program forward: https://lnkd.in/dbrSXMjZ Cecile Durand, Charisse Fernandez and Brian Wile, PhD will be happy to discuss potential collaborations. See you in Basel!

After such a great response to our recent #TheWeeklyBioanalysis #podcast episode on the topic, our hosts, Dominic Warrino, PhD, and John Perkins, PhD, revisit the topic of #GLP1 #Analogue development and the role #bioanalysis plays in this relatively new and popular topic. In the words of John, “Everyone else is talking about this; why shouldn’t we?” And wow, they have a lot to say about it on this second pass at the advances being made in this ever-growing and ever-changing field. The guys talk about the latest developments in the #GLP1analogue space, KCAS Bio’s experience with #GLP1analogs, options when choosing the right technology for these studies, some of the challenges associated with the #LCMS Approach, the options available around #LigandBindingAssays for #GLP1analogues in tissues, and whether there may even be value in conversation about a #HybridLCMS approach!

In the 12th episode of “The Conversational Flow” podcast, our hosts Brian Wile, PhD and Adam C. welcome two special guests – Sean Burke of De Novo Software and Ryan Brinkman of Dotmatics – who join them to discuss the answers to a number of specific questions about #HighContentAnalysis: How can we manage and derive insight from higher complexity panels? How can this enormous amount of data be standardized? Once standardized, how can the process be automated? Why is more data challenging to deal with? How can we generate meaningful answers from known and unknown #antibody combinations? How can this type of analysis be #automated while still retaining the #SingleCell intensity detail needed? All these questions and more are discussed during the recent episode. Click here to check it out: https://lnkd.in/gguGaRrE

Targeted Protein Degraders (TPDs) are transforming cancer treatment by using the body’s own machinery to eliminate disease-causing proteins. With potential in both solid tumors and blood cancers, TPDs, including Molecular Glues and PROTACs, offer new therapeutic possibilities. In our latest blog, we explore their unique benefits, challenges, and the critical role flow cytometry plays in supporting their development. ?? Discover more about this innovative therapy and how KCAS Bio supports TPD research. https://lnkd.in/givxSaBD #TargetedProteinDegraders #CancerTherapy #FlowCytometry #Biotech #Pharmaceuticals

Join KCAS Bio for an insightful webinar: "Spectral Unmixing: Impact & Comparison Across Immunophenotyping Panels and Matrices." Are you ready to deepen your understanding of spectral unmixing and its impact on immunophenotyping? Our expert, Nassouh Mourabet, Scientist III in the Flow Cytometry department at KCAS Bio,?will present results from a recent validation of two IP panels on the Cytek Aurora in PBMCs. Additionally, you will learn to: ? Understand the constraints around using reference controls over the long term. ? Identify new parameters to test to help build best practices for single stain controls. ?? Date: Wednesday, September 25th ? Time: 1:00pm – 1:45pm EST ?? Webinar Registration: https://lnkd.in/gyNBYwdd Don’t miss this opportunity to expand your knowledge and enhance your bioanalytical capabilities! #Bioanalysis #Webinar #SpectralUnmixing #Immunophenotyping

We're excited to share a significant milestone in our global advancements in spectral flow cytometry! Natalie Carroll, Scientist III at KCAS Bio - Philadelphia, recently visited our KCAS Bio - Lyon site to lead the Performance Qualification and initial Assay Harmonization, following the success of similar harmonization efforts with our strategic partner in Australia, Crux Biolabs. During her visit, Natalie and team: ?? Implemented the performance qualification plan ?? Assisted with data analysis and interpretation ?? Ran our first assay transfer seamlessly The Lyon team has experience both with transferring assays between sites on our harmonized Fortessa platforms as well as working with the Cytek platform, so they were up to speed on the platform in no time! What this means for our Sponsors at KCAS Bio: ? Identical instruments are now available in Lyon, enabling global assay transfers for upcoming clinical trials. ? Our robust, internally validated general immunophenotyping panel has been successfully transferred and is ready for immediate use worldwide. ? This combination of technical capabilities, harmonization, and speed is unmatched in the industry, allowing us to meet the next generation of needs for our sponsors. But it wasn’t all work! Natalie enjoyed some fun highlights during her trip: ??? Food: Lyon is the city of gastronomy, though she missed out on the praline specialty due to a nut allergy. ?? Sightseeing: She explored Lyon and its iconic landmarks, and also enjoyed a trip to Paris and the charming town of Annecy. Stay tuned for more updates as we continue to enhance our global capabilities and ensure seamless integration across our facilities! #ScienceAccelerated #SpectralFlowCytometry #GlobalReach #CytekAurora

When it comes to #FlowCytometry instrumentation, there are a number of differences that may be involved. You may have different types of lasers, you might have a different path for the laser to follow to get to the detector, you can have different actual detectors, different filters in front of those detectors, not to mention the varying sensitivities or levels of power for any of these items. In episode #10 of “The Conversational Flow” #podcast, Brian Wile, PhD and Adam C. discuss all of these differences while comparing them and deciding which elements matter the most for your project. Click here to listen now: https://lnkd.in/gaSdsH-Y