Regulation of TTN as a mechanism of and treatment for heart failure: https://lnkd.in/e5n7TCHt Dominic E. Fullenkamp comments on Yuri Kim et al. (https://lnkd.in/eJh9_PpV)
The Journal of Clinical Investigation
图书期刊出版业
Ann Arbor，Michigan 1,388 位关注者
The JCI is the publication of the American Society for Clinical Investigation, an honor society of physician-scientists.
关于我们
The Journal of Clinical Investigation (JCI) is a top-tier venue for discoveries in basic and clinical biomedical research that will advance the practice of medicine. Founded in 1924, the journal is published by the American Society for Clinical Investigation (ASCI). The JCI has a 2022 Impact Factor of 15.9 with immediate free access to its research articles to produce an ideal home for authors seeking the widest possible audience for their most important work. The journal is headed by Editor in Chief Dr. Elizabeth M. McNally and an Editorial Board of peer scientists at Northwestern University. The JCI provides free access to all of its research articles.
- 网站
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https://www.jci.org
The Journal of Clinical Investigation的外部链接
- 所属行业
- 图书期刊出版业
- 规模
- 11-50 人
- 总部
- Ann Arbor，Michigan
- 类型
- 非营利机构
- 创立
- 1924
- 领域
- Biomedical research
地点
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主要
获取路线
2015 Manchester Road
US，Michigan，Ann Arbor，48104
The Journal of Clinical Investigation员工
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Denis Seger
Independent sales contractor for advertising sales
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Rachel Nelson
at Journal of Clinical Investigation
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Holger Morgenstern
Dean, Faculty of Computer Science at Albstadt-Sigmaringen University, Professor IT Security, Digital Forensics, Computer Science. Personal views only.
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Erika Noerenberg
Adv. Cybersecurity Advisor
动态
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High titers of IgG to Epstein-Barr virus glycoprotein 42 correlate with lower risk of nasopharyngeal carcinoma: https://lnkd.in/eRiBDY77 Benjamin E Warner & Kathy HY Shair comment on Xiang-Wei Kong et al. (https://lnkd.in/e459Q7q4)
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Purifying and profiling lysosomes to expand understanding of lysosomal dysfunction-associated diseases: https://lnkd.in/g7x_3zBM Ali Shilatifard & Issam Ben-Sahra comment on Daniel Saarela et al. (https://lnkd.in/e6UvfekB)
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Do antibodies that protect against Epstein-Barr virus affect the risk of its associated cancers? Mu-Sheng Zeng & team present a large-scale population-based study, revealing gp42-IgG antibody as protective against EBV-associated nasopharyngeal carcinoma: https://lnkd.in/e459Q7q4 The figure shows HLA-II expression in nasopharyngeal atypical dysplasia.
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Titin, the largest known human protein, is vital for normal heart muscle contraction. Yuri Kim & team now discover an intron-mediated enhancer crucial for TTN gene expression and cardiomyocyte contractility: https://lnkd.in/eJh9_PpV The figure shows deletion of the TTN regulatory element E1 leads to fewer sarcomeres and less GFP expression in human cardiomyocytes from induced pluripotent stem cells.
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An advancement in lysosomal research with diagnostic applications! Esther M. Sammler & team present a tagless method for profiling lysosomal content from clinical samples: https://lnkd.in/e6UvfekB
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CYP24A1 mutation cause hypercalcemia and kidney stones, but its role in mineral homeostasis is unclear. Myles Wolf & team now show intestinal Cyp24a1 regulates local vitamin D, and suggest it could serve as a target in secondary hyperparathyroidism in chronic kidney disease. https://lnkd.in/e5-gyayV The figure shows Cyp24a1 mRNA is basally expressed in proximal tubules of the outer cortex and its expression increases across the cortex along the proximal tubule 6 hours after calcitriol injection.
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How can we make PARP inhibitors more effective in castration-dependent prostate cancer? Francesca Demichelis & team identify the DNA repair gene LIG1 as a sensitizer to PARP inhibitors in multiple tumor models. https://lnkd.in/ei4YwAJ4 The figure shows increased double-stranded DNA breaks in xenograft tumor sections lacking LIG1 that had also been treated with PARP inhibitors.
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Reinvigorating drug development around NGF signaling for pain: https://lnkd.in/ei4JVjAc Andy Wangzhou & Theodore J Price? comments on Chloe J. Peach et al. (https://lnkd.in/esURxJgH)
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The N-type calcium channel rises from the ashes: https://lnkd.in/eihvyFEG Maria A Gandini & Gerald W Zamponi comment on Cheng Tang et al. (https://lnkd.in/eEAcV2Hm)
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