JMSACL (Journal of Mass Spectrometry & Advances in the Clinical Lab)

Source: (Analytical and bioanalytical chemistry) Developed and validated a candidate reference measurement procedure (RMP) for total 3,3',5-triiodothyronine (T3) in serum using isotope dilution-LC-MS/MS. Enhanced performance over the 20-year-old RMP with simplified serum cleanup. Method showed no significant T4 conversion, linearity from 0.016 to 13.086 nmol/L, and low imprecision (0.1-1.9% intra-assay, 0.5-1.2% inter-assay). Bias analyzed with SRM971 was -0.34 to -1.65%. Candidate RMP is reliable, traceable, and shows potential for standardization of assays.

Source: (Biotechnology notes (Amsterdam, Netherlands)) MALDI-TOF MS offers a rapid, cost-effective method for screening recombinant protein-expressing E. coli, improving efficiency over traditional methods like electrophoresis and western blotting. This study highlights its ability to quickly identify clones producing various proteins, including sfGFP and antibody fragments.

Source: (Journal of mass spectrometry : JMS) Developed LC-MS/MS method quantifies occidiofungin in rabbit plasma post hydrogel administration. Validated with 30-15,000 ng/mL range. Supports toxicity study; plasma concentrations mostly below quantification limits, indicating low vaginal absorption.

Source: (JMSACL) Retraction notice for "Identification of brexpiprazole metabolites in human urine for patient compliance monitoring" [Clin. Mass Spectrom. 6 (2017) 21–24].

Source: (ACS pharmacology & translational science) Study evaluates CGS21680's effect on Alprazolam's sleep properties via mass spectrometry imaging. CGS enhances Alp's sleep induction by reducing latency and extending duration, influencing Alp's brain distribution and blood-brain barrier permeability. Co-administration regulates GABA, glutamate, and glutamine during sleep.

Source: (Peptides) Study evaluates plasma arginine vasopressin (AVP) measurement methods for diagnosing central diabetes insipidus (CDI). Compares conventional radioimmunoassay (RIA) with liquid chromatography-tandem mass spectrometry (LC-MS/MS). 335 samples from 77 individuals (23 CDI, 54 controls) analyzed during hypertonic saline loading. LC-MS/MS shows lower detection limits, broader quantification range, and comparable diagnostic accuracy to RIA. Findings support LC-MS/MS as a viable alternative for clinical AVP quantification.

Source: (Journal of mass spectrometry and advances in the clinical lab) Developed and validated a sensitive LC-MS/MS assay for quantifying plasma oxytocin, addressing limitations of current immunoassays. Achieved quantification range of 1-75 ng/L with precision <10%, accuracy 94-108%, and uncertainty <15%. Method suitable for clinical use.

Source: (Therapeutic drug monitoring) Developed and validated a method for simultaneous quantification of ganciclovir, acyclovir, and letermovir in serum using liquid chromatography-tandem mass spectrometry. The method showed accuracy and precision, with median trough concentrations measured in transplant recipients. Successfully applied in clinical settings for therapeutic drug monitoring.

Source: (Scientific reports) REIMS shows potential for real-time analysis of steatotic liver tissues, focusing on lipid profiling. Study established protocols for tissue handling, revealing tissue size affects sensitivity and lipid profiles. Identified triacylglycerides, fatty acids, and ceramides as key lipid classes, with ceramides linked to advanced steatosis. Emphasizes need for standardized preparation for accurate lipid analysis and clinical application.

Source: (Analytical chemistry) Isotope-coded photochemical derivatization with LC-MS and MS imaging enables sensitive quantification and localization of amine metabolites linked to pancreatic diseases. The method enhances detection and identification of metabolites, revealing new biomarkers for acute pancreatitis and pancreatic cancer, improving diagnostic capabilities.