International Fibrinogen Research Society (IFRS)

?? #Paper: “Elucidating the physicochemical interactions between fibrinogen and surfactant mixtures: Implications for pharmaceutical sciences.” ?? https://lnkd.in/daTKcnXA ?? This study explores how fibrinogen, a key blood clotting protein, interacts with dicloxacillin and CTAB, revealing structural modifications that could impact drug delivery systems. ?? Authors: Ramón Rial Silva, Michael González-Durruthy & Juan M. Ruso. #DrugDelivery #ProteinInteractions #BiomedicalResearch

???Applying Artificial Intelligence to Uncover the Genetic Landscape of Coagulation Factors This review explores the role of artificial intelligence, particularly machine learning, in advancing coagulation genetics by improving variant detection, genotype-phenotype correlations, and functional impact predictions—paving the way for precision medicine in coagulation disorders. ???Read this article at:?https://lnkd.in/g_7rCbe6 ???Authors:?Giulia Soldà | Rosanna Asselta

Post doc position open in the fibrin(ogen) field!

???Fibrin Film on Clots Is Increased by Haematocrit but Reduced by Inflammation: Implications for Platelets and Fibrinolysis This study uncovers the dual role of fibrin films in blood clots, revealing how inflammation reduces fibrin film formation, promoting platelet adhesion and clot growth, while increased fibrin film impairs fibrinolysis by reducing plasmin generation. ???Read this article at:?https://lnkd.in/epuQZkcF ???Authors:?Ghadir Alkarithi | Cédric Duval | Helen McPherson | Leander Stewart | Ilaria De Simone | Fraser MacRae | Robert Ariens

Over the summer, I participated in a National Science Foundation (NSF) Research Experience for Undergraduates (REU) at the University of Michigan. I examined the surface structure of poly(dimethyl siloxane) (PDMS) elastomer/aromatic polysiloxane oil mixtures as fouling-release coatings (FRC) to prevent marine biofouling, reducing fuel consumption and greenhouse gas emission, a major contributor to climate change, under the advisement of Dr. Zhan Chen and in collaboration with North Dakota State University and the Office of Naval Research. We probed the oil bulk, oil/air, oil/water, and oil/protein buried interfaces in situ nondestructively using face-up and face-down picosecond and time-dependent pump-probe femtosecond sum frequency generation (SFG) vibrational spectroscopy to determine the molecular orientation and adsorption kinetics using fibrinogen as a model protein. We also analyzed the surface and mechanical properties of FRC to supplement SFG studies using static contact-angle goniometry and profilometry. I am pleased to announce that a paper I co-authored on this work was published by the American Chemical Society (ACS) in Langmuir. I am grateful to Dr. Chen and my collaborators for their hard work and the opportunity to research alongside them. Gomez, F.; Roter, S. F.; Rossi, D.; Wu, G.; Safaripour, M.; Webster, D.; Chen, Z. Molecular Structures of Surfaces and Interfaces of Poly(Dimethylsiloxane) Incorporated with Silicone Oils Containing Phenyl Functionality. Langmuir 2025, 41 (3), 1985–1996. https://lnkd.in/eeiX__U2.

Our latest systematic review on fibrinogen replacement in trauma haemorrhage: Neuroscience, Surgery and Trauma Centre - No association between early fibrinogen replacement and mortality or transfusion - No association for superiority between Fg concentrate or cryoprecipitate -> Urgent need for further RCTs to assess the efficacy of early fibrinogen replacement, preferred strategy (goal-directed vs empiric) and optimal therapeutic product for both patient outcome and cost effectiveness.

Is it time to re-visit our understanding of clot formation, contraction and reperfusion? Should our approach to stroke care involve disaggregating blood clots by targeting von Willebrand Factor, rather than dissolving fibrin? Basking co-founder and Chief Medical Officer Shahid Nimjee, M.D., sat down with interventional cardiologist C. Michael Gibson, M.S., M.D. to discuss Basking’s revolutionary approach to treat ischemic stroke and the potential of von Willebrand Factor to safely target large vessel occlusion while also preventing downstream hemorrhages. Here’s an excerpt from that conversation. Watch the full Clinical Trial Results interview: https://bit.ly/40l2VJ8 #drugdevelopment?#clinicaltrials #neurology #vWF #Stroke #PatientsAreWaiting

Exciting Research Update! Thrilled to share the first research publication from my postdoc in Advanced Healthcare Materials: "Bioprinted Micro-Clots for Kinetic Analysis of Endothelial Cell-Mediated Fibrinolysis." This work introduces a novel 3D-bioprinted micro-clot model that enables real-time assessment of endothelial-driven fibrinolysis. This platform provides new insights into the dynamic interactions between the endothelium and fibrin-rich thrombi, offering a powerful tool for studying thrombosis, hemostasis, and vascular dysfunction. Our findings have the potential to improve disease modeling, drug screening, and personalized medicine for clot-related disorders. Huge thanks to my co-authors Jonathan Chang, Kelsey Brew, my PI Shuichi Takayama, the BME department Alyssa Panitch, and the ATLANTIS KUH program leadership Nael A. McCarty, Stacy Heilman, Lou Ann Brown, Douglas Eaton for their support in driving this research forward. Thank you to my scientific village who always supports my research endeavors, Curtis Henry, Ph.D., Edikan Archibong Ogunnaike, PhD Cynthia Jones, Nelly Mateeva, and countless others. As I continue expanding my postdoctoral work, I’m excited to connect with others in hematology, tissue engineering, vascular biology, and translational medicine to explore future collaborations. Check out the full article here: https://lnkd.in/eS2UQHCC #TissueEngineering #VascularBiology #Hematology #Bioprinting #Fibrinolysis #Research #Microphysiologicalsystems #EndothelialBiology

Check out this revolutionary article that used cryo-EM to study the structure of native coagulation Factor XIII complex!

Check out this article that found that all-trans retinoic acid (atRA) polycaprolactone (PCL) microparticles strengthened a fibrin construct for tissue engineering applications!