Inscopix, Inc.

?? ??? ?????????? ?????????? ?????? ???? ?? ?????????? ?????????????????????? ???? ?????????????????? ???????????????????????? ?????????? ???????????? ???? ???????? ?????????? ????????. A research highlight with ???????????? ??????????????, ?????? ???????? ?????????? ????????????????????, discusses her research using Bruker’s multiphoton microscopy and the nVista to study the behavior of astrocytes, which are glial cells in the brain that impact #sleep regulation and homeostasis. Investigating their role has important implications for our understanding of sleep and mammalian health. #neuroscience #WorldSleepDay

Big congratulations to Julio Esparza and the team from Liset M de la Prida Lab at CSIC for their latest publication in Neuron! Their work leverages ????????-?????????? ?????????????????? ?????????????? ???????? ???????? to uncover how deep and superficial CA1 pyramidal cells encode ????????????????, ?????????????????????? ?????????????? ???????? in the hippocampus. Read the full study here ?? https://hubs.ly/Q039g5QR0 Key insights: ? ???????????????????????? ?????????????? ???? ???????? & ?????????????????????? ?????? ?????????? reveals distinct spatial coding strategies. ? ???????? ?????? ?????????? ?????????????????????? ?????????? ???????? ?????????? ????????, while superficial cells maintain stable representations. ? ????????????????, ?????????????????????????? ?????????????????????? ?????????????? ???????? highlight the complexity of hippocampal population dynamics. This study represents a major step forward in understanding how the brain encodes spatial information at the population level. Exciting times for neuroscience! #neuroscience #brain #lifesciences #therapeutics

We are excited to be presenting the seminar “???????????? ?????????????? ?????????????????????????? ?????? ???????????????????????????????? ?????????????????????? ?????????????? ???? ?????? ???????????????? ????????????????” hosted by the National Center for Wellness & Recovery. ?? https://hubs.ly/Q038fkJV0 The presentation by Matthew Whitmire, PhD, and Morgana Favero, MD, PhD, will introduce the complete Inscopix solution and workflow to enable simultaneous calcium imaging and behavioral experiments. They will also share some exciting results from the Inscopix Discovery Lab, where the fields of neurotherapeutics and drug discovery are being advanced with innovative research. #neuroscience #therapeutics #drugresearch

Huge congratulations to the team from ?????????? ??????????????’?? ?????? at University of Washington for their work using single-cell calcium imaging with #nVoke to longitudinally track neurons during Pavlovian reward and fear conditioning. ??https://hubs.ly/Q034P-yN0 ?????? ??????????????????: ? The majority of central amygdala (CeA) neurons are responsive to either a reward or fear-related unconditioned stimulus (US). ? The group observed six distinct types of valence encoding that were selective for different stimuli. ? CeA encodes multiple aspects of positive and negative reinforcing stimuli, but the prevailing responses relate to the encoding of the valence encoding of the US. This study has important implications for exploring the full extent to which the CeA encodes the salience or valence of positive and negative affective information. #neuroscience #behavior #neuron

Big shout-out to ???????? ?????? ?????? and the team from ?????? ???????? ????????'s lab at the Institute for basic science (IBS) for their recent work using calcium imaging to uncover how VIP neurons shape dopamine-modulated working memory! ?????? ??????????????????: ? VIP neurons encode working-memory signals during delay periods and depend on dopamine. ? Reducing D1 receptor expression in VIP neurons weakens these signals and impairs task performance. ? Dopaminergic stimulation enhances VIP neuron selectivity, improving memory-related activity. This research provides new insights into how dopamine shapes cognitive function and may have implications for understanding disorders involving executive dysfunction. Read more: https://hubs.ly/Q033Ymts0 #neuroscience #dopamine #memory

?? ?????????????????????????? ?????????????? ???????????????? ?????? ???????????????? ?????????????????????????????? ?????????????? ???????????????? ???????? ????-????????, ?? ??????????-?? ???????????????????????????? ???????? ??????????????????. This work will be featured at the American College of Neuropsychopharmacology’s 63rd Annual Meeting in Phoenix, AZ. The poster presentation by ???????????????? ??????????????, ????.??., will be on ??????????????, ???????????????? ???????? ???????? ?? ???? ?? ???? and a reception will follow. For their detailed findings and implications, visit poster ???????? at the ACNP Annual Meeting. #ACNP2024 #Neuroscience #Therapeutics

???????????????????? ?????? ?? ?????????? ???????? ???? ?????????????? ???????????????? ?????????????????????????????? ?????? ?????????????????? ????????????????????????. In their recent publication, “Harnessing Miniscope Imaging in Freely Moving Animals to Unveil Migraine Pathophysiology and Validate Novel Therapeutic Strategies,” published in Synapse, researchers ???????????????? ????????????, ???????????????? ??????????, Paolo Botta, and collaborators at Lundbeck dive into how one-photon miniscopes drive the development of novel therapeutic strategies for effective migraine management. ?????? ???????????????? ???????? ?????? ????????????: 1. Holistic Understanding: Integration of behavioral studies with neurovascular imaging using one-photon imaging provided a comprehensive view of migraine-related mechanisms. 2. Chronic Migraine Models: Demonstrated the potential to create chronic migraine models, paving the way for insights into long-term therapeutic interventions. 3. Dual-Color Imaging using Inscopix Miniscope: Enabled deeper exploration of the interactions between neuronal activity, neuropeptide release, and vascular responses, advancing our understanding of migraine pathophysiology. This study has important implications for future research studying other processes at play during migraines using miniscopes. Read the full publication here: https://hubs.ly/Q02-9gDn0 #neuroscience #migraine #therapeutics

A Big Congratulations to Dr. Biafra Ahanonu, Dr. Andrew Crowther, and the team from Professor Allan Basbaum lab at University of California, San Francisco on their Nature Methods publication! Their research has overcome significant challenges in ?????????????? ???????????? ???????? ????????????????, enabling ????????-???????? ?????????????? ?????????????? in freely moving animals ?????? ????????????????????????: ?Development of a cost-effective spinal imaging chamber combined with multi-step surgical procedures, ensuring stability and long-term functionality. ? A ???????? ?????????? ???? ???????? using Inscopix nVue Lscape Module for bilateral imaging, visualizing activity across both sides of the spinal cord. ? ???????? ????????-?????????? ?????????????? capabilities to monitor both neural dynamics and microglial changes in real time. ? Real-time tracking of ???????? ????????????????????, ?????????? ???????????? ??????????????????, and ???????????????????? ????????????????, providing critical insights into chronic pain mechanisms and spinal cord physiology. ? Long-term imaging in freely moving animals, enabling coupling neural activity with behavior to unlock new discoveries in spinal cord research. Discover how this breakthrough is transforming spinal cord research and unlocking new insights into chronic pain, nerve injury, and neurological disorders ??Read the publication: https://hubs.ly/Q02Ynkvq0 ??Watch the webinar: https://hubs.ly/Q02YnCFn0

Can’t believe #SfN24 was almost a month ago! We’re still buzzing from the fascinating conversations and innovations in neuroscience we encountered. ?? If you missed the action or want to relive it, check out our #SfN2024 recap by Bruker Life Science Writer ?????????????? ????????????, where she captures the energy and insights that made this year unforgettable! https://hubs.ly/Q02XdmdH0

Ever wondered what drives an aggressive state in the brain? ???????????? ???????????????????????? et al. from ?????????? ??. ????????????????'s lab at Caltech has some fascinating answers! Published in Cell, this study uncovers how neuropeptide signaling in the hypothalamus shapes aggression. ?????? ????????????????: ??This work shows that ???????????????? and ?????????????????????? ?????????????????? in the VMH encodes a sustained state of aggression. ??Employing "????????????????????????," which combines CRISPR gene editing and ????????????-???????? ?????????????? ?????????????? with #????????????, the study pinpointed how disrupting neuropeptide receptors reduces aggressive behavior without altering other social responses. ??The study highlights unique "???????? ?????????????????? ????????????????," where neural circuits actively maintain internal states like aggression, driven by neuropeptide signaling. This research is a leap toward understanding how internal states are encoded and maintained in the brain! ?? https://hubs.ly/Q02WFgMr0