IHI ILLUMINATE project

?? In the Spotlight: Ayhan Gursan ?? ? ILLUMINATE's project coordinator UMC Utrecht is a pioneer in the field of Metabolic MRI (#MeMRI), the technique used in ILLUMINATE. ? Ayhan Gursan is a PhD student at UMC Utrecht working on the technology used for MeMRI. ILLUMINATE build on the foundation laid in Ayhan's research. ? During his PhD, Ayhan sought to better understand the glucose metabolism in the body by improving non-invasive metabolic imaging via Deuterium Metabolic Imaging (DMI). He developed a hardware to improve the sensitivity and resolution of metabolic imaging. His research provides tools for clinical translation, particularly in therapy response assessment and patient stratification.? ? ?? Cancer cells behave differently than healthy cells. They use more glucose as an energy source, which is known as the Warburg effect. Non-invasive metabolic imaging allows to track glucose use and could give insight into: ? ?? Early detection of metabolic changes in tumours ?? Real-time monitoring of cancer treatment response ?? Personalized medicine by tailoring treatments based on a patient's unique metabolism ? "The benefits of this technique could improve cancer care for patients by enabling more precise and effective treatment strategies." ? #Spotlight #MeMRI #Imaging #Innovation #Metabolism #CancerResearch

?? Do you want to stay up-to-date about ILLUMINATE? ?? ? Subscribe to our newsletter via the link below to receive: ? Project updates ?? Get to know the people driving ILLUMINATE ?? Highlights of the project ? Subscribe here ?? https://lnkd.in/es6fZrQq ? #Newsletter #Research #Innovation #Lutetium #MeMRI #PatientEngagement

?? Who are in the Management Team of ILLUMINATE? ? The management team in ILLUMINATE manages the day-to-day operations of the project to make sure that the work that is performed is serving the goals of the projects. ? The Management Team consists of 5 people: ?? The Project Coordinator Dennis Klomp from the UMC Utrecht ?? The Project Lead Karlijn van der Schilden from NRG PALLAS ?? Yolanda Alvarez Casao from NRG PALLAS ?? Irina Stoica from Lygature ?? Sophie Huiskes-Berends from Lygature ? Learn more about their backgrounds and roles in ILLUMINATE here ??https://lnkd.in/e95BDz_v

?? ????????????????????: ?????? ?????? ???????? ??????????????????? ? ILLUMINATE aims to optimize diagnosis and treatment of #patients with advanced prostate cancer and we want to achieve this by working together with patients and the public. ? To make sure that the patient voice is represented and heard in ILLUMINATE, we are setting up a Stakeholder Involvement Community (#STIC). Both patients, their family members, and clinicians can be a member of the STIC. ? The STIC will advise on project developments and plans including how the outcomes of the project can be implemented in the long-term in the best way to benefit patients. ? Learn more about patient and public involvement in ILLUMINATE here ?? https://lnkd.in/eS2DvdM3 #PatientandPublicInvolvement #STIC #Innovation #Lutetium #MeMRI #ProstateCancer #CancerResearch

?? World Cancer Day ?? ? Today is World Cancer Day, with this year's theme "United by Unique". World Cancer Day reminds us why the work of ILLUMINATE is still very much needed. ? In ILLUMINATE, we focus on (metastatic) prostate cancer, which is for men the second most commonly occurring cancer. Treatments available, including #lutetium-177-PSMA therapy, are not working for all patients and therefore ILLUMINATE wants to make a step forward in personalised treatment in #prostate cancer. ? In order to achieve this, we need to know more about the underlying mechanisms that are involved in therapy resistance. #MeMRI offers the capabilities to investigate this and will be used to detail characteristics of a tumour and its response to treatment. ILLUMINATE strives to ‘treat the right patient with the right treatment’, because every patient is unique.? ? Read more about prostate cancer and ILLUMINATE ?? https://lnkd.in/eja_DNCp ? #WorldCancerDay #UnitedbyUnique #ProstateCancer #MeMRI #Lutetium-177 #Innovation #CancerResearch

?? Why Lutetium-177? ?? ? Prostate cancer remains one of the most prevalent cancers worldwide, and innovative treatments are crucial in improving patient outcomes. #Lutetium-177 is one of these promising treatments that is used for the treatment of metastatic prostate cancer. ? Lutetium-177 specifically binds to prostate-specific membrane antigen (#PSMA) and therefore the molecules selectively bind to tumour cells, delivering radiation directly to the cancer while sparing most surrounding healthy tissue. ? Lutetium-177-PSMA is a so-called #theranostic approach wherein imaging and treatment can be done at the same time. Via #MeMRI, valuable insights into the response of patients to the treatment can be obtained. ? ?? Lutetium in ILLUMINATE ? Lutetium-177 will be used in our clinical trial ? ILLUMINATE aims to increase the lutetium-177 production to meet the growing demand ? Focus on recycling of the raw material to make production more sustainable Read more about lutetium in ILLUMINATE on our website ?? https://lnkd.in/eumyQZDH #ProstateCancer #Lutetium177 #NuclearMedicine #OncologyResearch #Innovation

?? The expected impact of ILLUMINATE ?? ? What are we expecting to achieve with ILLUMINATE? ? ILLUMINATE aims to generate a widespread impact ranging from clinical and scientific to economic and technological and societal. ? ??Highlights ? ILLUMINATE strives to ‘treat the right patient with the right treatment’ and prevent unnecessary treatment-associated adverse events. ? Bring to market widely available and affordable MeMRI-based solutions that will improve therapeutic effectiveness of novel theranostic interventions. ? Better?understanding of fundamental molecular mechanisms?of health and disease, providing?novel starting points?for prevention and treatment.? ? Read more about the expected impact of ILLUMINATE here ?? https://lnkd.in/eJ29Kq8S ? #Innovation #prostatecancer #lutetium #MeMRI?

???????? ???????????? ?????????? ???? ?????????? ???? ?????????????????????? ? What role does Metabolic Magnetic Resonance Imaging (#MeMRI) play in the ILLUMINATE project? ? MeMRI is a recently developed technique, which makes it possible to visualize chemical reactions happening in the body. This allows researchers and clinicians to assess how tumours respond to treatment, providing valuable insights into which patients respond to treatment and which do not. ? ILLUMINATE's study will serve as a clinical validation of the MeMRI technology for metastatic prostate cancer patients and aims to expand the availability of the technique so more patients can benefit from it. ? ?? Discover more about MeMRI in ILLUMINATE on our website ?? https://lnkd.in/eKQwi49J ? #Innovation #research #MeMRI #prostatecancer?

The power of #collaboration! ?? In ILLUMINATE, we aim to improve the lives of prostate cancer patients by bringing together public and private #partners. In ILLUMINATE, we are working together with 15 partners to achieve our goal: Transforming the approach to #theranostics-based advanced stage cancer treatment while increasing the overall availability of #lutetium. Visit the partners page on our website to meet the 15 partners in ILLUMINATE via the link below and read about their work on our Work Packages page?? Cancer Research UMC Utrecht, UMC Utrecht, Euro-BioImaging, Philips, SYNLAB Italia, Consiglio Nazionale delle Ricerche, Università degli Studi di Torino, Bracco Imaging, Tesla Dynamic Coils, WaveTronica B.V., Lund University, NRG PALLAS, Amsterdam UMC, University Hospital Essen, Lygature. #Collaboration #Research #PublicPrivatePartnership

?? Website launch ?? We are excited to announce the launch of the ILLUMINATE website! The website is now live at: www.ihi-illuminate.org ? ILLUMINATE is a European consortium of academic and industrial leaders who work together to improve prostate cancer treatment. ? ILLUMINATE aims to demonstrate the unique value of recently developed Metabolic Magnetic Resonance Imaging (#MeMRI) visualizing chemical processes in the body to significantly improve effective application of #theranostics – an approach combining diagnosis, treatment, and continuous follow up of a condition. ? ILLUMINATE will provide the first clinical translation of MeMRI, with application to metastatic #prostate cancer. This will pave the way for future expansion of the technology for use in earlier #cancer stages and in other cancer types. ? In parallel, ILLUMINATE seeks to increase the overall availability of #lutetium and develop more sustainable production methods. ? ILLUMINATE is a four-and-a-half-year public-private partnership with 15 partners, funded by the Innovative Health Initiative (IHI). The consortium is coordinated by UMC Utrecht, together with NRG PALLAS as a project lead. ? To learn more about the project, check out our website ?? www.ihi-illuminate.org ? Cancer Research UMC Utrecht, UMC Utrecht, Euro-BioImaging, Philips, SYNLAB Italia, Consiglio Nazionale delle Ricerche, Università degli Studi di Torino, Bracco Imaging, Tesla Dynamic Coils, WaveTronica B.V., Lund University, NRG PALLAS, Amsterdam UMC, University Hospital Essen, Lygature.