Greenstone Biosciences

???Upcoming Conference News! ?? We are looking forward to showcasing our recent work this weekend at the American Heart Association (AHA) Scientific Sessions in Chicago, where Christopher Yan, Senior Research Associate, will present our latest advancements.?Co-authors include?Kyle Swanson, Souhrid Mukherjee, Parker Walther, Celine Lai, Rabindra V. Shivnaraine, Jeremy Leitz, Paul Pang, James Zou, & Joseph C. Wu. ? This prestigious event gathers leading researchers and innovators in cardiovascular science to exchange breakthrough insights across various areas of heart health. With topics ranging from basic science to population studies and clinical care, this year’s conference promises to be transformative in advancing our collective knowledge and approach to cardiovascular disease. During our presentation, we’ll dive into the power of our ADMET-AI platform, an innovative AI/ML solution for predicting drug toxicity. Designed with high accuracy and rapid evaluation capabilities, ADMET-AI is reshaping how we assess drug safety—especially for cardiotoxicity—early in the drug discovery process. By leveraging induced pluripotent stem cells (iPSCs) and comprehensive machine learning tools, our platform provides enhanced forecasting of drug-induced cardiotoxicity, minimizing risks and aiding in the creation of safer therapeutics. Catch us at the conference as we discuss how?Greenstone Biosciences?is pioneering safer, more effective therapies. If you will be attending the conference in person, we will be located at poster 14 in Zone 3 beginning at 12:20pm this Sunday 11/17. Join us and experience the future of drug discovery and cardiovascular health! Learn more about AHA Scientific Sessions here:?https://lnkd.in/dVZSYuq

We're excited to share our latest publication, "Multiscale Drug Screening for Cardiac Fibrosis Identifies MD2 as a Therapeutic Target," featured in?Cell by Cell Press! Check out the full article here: https://lnkd.in/gvnQdZU2 Congratulations to Dr. Hao Zhang, who led this impactful study, and our incredible collaborators at Stanford Cardiovascular Institute, University of California, Davis, University of Arizona College of Medicine - Phoenix, and MD Anderson Cancer Center, including Phung N Thai, Lu Ren, Xuekun WU, Dirk Siepe, Hye Sook (Danielle) Shin, Arianne Caudal, Wilson Tan Lek Wen, Wenqiang (Eric) Liu, Wenjuan zhu, and Nipavan Chiamvimonvat. Special thanks to our own Greenstone Biosciences computational scientists Rabindra V. Shivnaraine, Souhrid Mukherjee, and Jeremy Leitz for their invaluable contributions in identifying this molecular target. Why does this research matter? Fibrosis, a condition that can lead to the maladaptive formation of the?extracellular matrix, contributes to nearly 45% of deaths in the developed world. Leveraging Greenstone's AI-integrated hiPSC platform, we identified artesunate—a long-standing FDA-approved malaria drug—as a top candidate with promising antifibrotic effects. Through rigorous screening and validation using 3D-engineered heart tissues and animal models, we found that artesunate targets MD2 to counteract fibrosis effectively. Broad Implications: This breakthrough showcases how Greenstone Biosciences is advancing drug discovery, providing potential for safer, more effective therapies for fibrosis-related conditions. Our multiscale approach not only validates artesunate’s therapeutic potential for cardiac fibrosis but also underscores our commitment to transforming patient care. Together, we’re paving the way toward impactful therapies that address some of healthcare's most pressing needs. Check out the full research paper here:?https://lnkd.in/ghXKFRhh #GreenstoneBiosciences #DrugDiscovery #CardiacFibrosis #iPSCs #Biotechnology #Innovation

Greenstone Biosciences is thrilled to congratulate Geoffrey Hinton and John Hopfield on receiving the Nobel Prize in Physics for their foundational discoveries in artificial neural networks, which have revolutionized #MachineLearning. Their pioneering work has transformed computational tools, enabling us to develop precise models at every phase of drug development. By incorporating multi-dimensional complexities, these models provide the realistic, predictive, and generative capabilities necessary to identify key biological targets and create novel therapies for diseases with unmet needs. At Greenstone Biosciences, we utilize these groundbreaking advancements for #DrugDiscovery. Inspired by the seminal contributions of Hinton and Hopfield, we are pushing forward to develop safer and effective drugs. Our machine learning platforms allow us to predict drug interactions and safety with Greenstone ADMET-AI (https://lnkd.in/gJBFShr2..), model intricate biological systems, and collaborate with our biobank to de-risk clinical development. Ultimately, we are accelerating the journey from discovery to the clinic. This Nobel Prize not only honors their visionary achievements but also underscores the immense potential of AI in healthcare. At Greenstone Biosciences, we embrace a future where innovation and dedication guide us toward life-saving breakthroughs. — The Greenstone AI/ML Team Rabindra V. Shivnaraine Jeremy Leitz Souhrid Mukherjee Kyle Swanson #NobelPrize #AI #HealthcareInnovation

Advancing Drug Discovery for Duchenne Muscular Dystrophy: Greenstone Biosciences' Associate Director of Research and Development, Dr. Paul Pang, has been funded by the California Institute for Regenerative Medicine (CIRM) to focus on drug discovery for Duchenne muscular dystrophy (DMD),?one of the most severe forms of inherited neuromuscular disease. Utilizing multiple patient-derived iPSC-derived cardiomyocytes from diverse DMD mutations and genetic backgrounds, this grant project will characterize these cells as a tool to accelerate and de-risk drug discovery for DMD-associated cardiomyopathy. At Greenstone, we offer a broad range of?human induced pluripotent stem cell?(hiPSC) lines, including DMD and healthy control lines.?These cell lines are?available for purchase to support research efforts worldwide. Learn more about the project here:?https://lnkd.in/gq-rpq2g Browse our available cell lines here:?https://lnkd.in/gJBxJmEK

The latest review, co-authored by Greenstone Biosciences,?in the European Heart Journal, titled "Clinical trials in-a-dish for cardiovascular medicine" is now live! Cardiovascular diseases continue to be a major global health challenge, with current drug development approaches often hindered by high failure rates, particularly when transitioning from animal models to human trials. In light of the FDA Modernization Act 2.0, our review highlights the growing potential of human induced pluripotent stem cells (iPSCs) as a powerful tool in advancing cardiovascular drug discovery. The review covers key advancements in iPSC differentiation and their role in providing patient-specific platforms for drug testing. We also outline a forward-looking framework for future clinical trial design, integrating iPSCs with microphysiological systems, clinical pan-omics, and AI. These innovations have the potential to significantly enhance drug development success and reshape the future of cardiovascular healthcare.? We invite you to explore the full article here:?https://lnkd.in/gESFNm-p To learn more about Greenstone Biosciences and our cutting-edge research, visit us at?greenstonebio.com. #CardiovascularResearch #StemCells #PrecisionMedicine #iPSC #DrugDiscovery #ClinicalTrials #AI #GreenstoneBiosciences

?? Event Highlight! ?? We’re proud to share that our Co-Founder, Dr. Joseph C. Wu, recently delivered the keynote address at Octane OC’s Cardiovascular Tech Summit 2024! ???? Dr. Wu, a global leader in stem cell research and cardiovascular medicine, presented groundbreaking insights on how innovations in stem cell biology and genomics are driving the future of cardiovascular health. His talk highlighted the powerful intersection of technology and biology in accelerating advancements in patient care, drug discovery, and regenerative medicine. At Greenstone Biosciences, we are honored to contribute to this exciting dialogue and remain committed to shaping the future of cardiovascular health. Thank you to everyone who attended and supported this incredible event! To read more about summit, click here: https://octaneoc.org/ctf/ If you are interested in reading more about the research happening at Greenstone Biosciences, check us out here: https://greenstonebio.com/ #CardiovascularHealth #StemCellResearch #PrecisionMedicine #TechSummit #GreenstoneBiosciences #HealthcareInnovation

Greenstone Biosciences was excited to share our open-access resources, including our leading ADMET-AI platform (https://lnkd.in/g9UT5J-E) and the provision of free iPSC lines to academic institutions, at the International Society for Heart Research North American Section (ISHR) in Long Beach, California. Co-founder Dr. Joseph C. Wu delivered a Plenary Lecture on 'Stem Cells & Genomics: From Precision Medicine to Clinical Trial in Dish,' highlighting the numerous applications of iPSCs in advancing human health and enhancing our understanding of diseases for novel drug discoveries.

We’re pleased to see the advancements in the iPSCelz? program. Congratulations to Creative Medical Technology Holdings Inc. (Nasdaq: CELZ) on reaching this important milestone. Proud to have contributed to the validation of the iPSC clinical line driving these innovations in regenerative medicine. #biotechnology #stemcells #innovation #GreenstoneBiosciences

Greenstone Biosciences was honored to participate in the recent retreat at Stanford University, hosted by the Stanford Cardiovascular Institute (CVI), University of Arizona Sarver Heart Center, Morehouse School of Medicine, and the University of Alabama at Birmingham. Our co-founder and Director of the Stanford CVI, Joseph C. Wu, delivered a compelling welcome address, setting the tone for an event filled with cutting-edge clinical and scientific discussions. We are particularly proud to have had one of our scientists, Souhrid Mukherjee, present a poster highlighting our proprietary ADMET tool, “ADMET-AI,” which can predict cardiotoxicity amongst other important properties (check out this tool here: https://lnkd.in/gpXc69Ph.). This presentation underscored our commitment to developing safer drugs through advanced predictive modeling. Being part of this vibrant community of researchers aligns perfectly with our mission at Greenstone Biosciences. We stand at the forefront of biotechnological innovation, leveraging our AI and hiPSC platform to revolutionize drug discovery. The insights and connections gained during this retreat will propel us further in our quest to accelerate the development of effective therapies, transforming patient care through precision and innovation.

? Limited Time Left To Save? Your FINAL CHANCE to save on your registration for the 4th iPSC Drug Development & Manufacturing Summit ends this Friday! Join industry experts including Kenai Therapeutics, Aspen Neuroscience, iPSirius, AstraZeneca and more as they showcase cutting-edge advancements across R&D and manufacturing. Find out more here: https://ter.li/lmcaec Session spotlights include:? ??Discuss how to streamline manufacturing processes with Aspen Neuroscience, Inc.? ??Unlocking the power of the world’s largest iPSC biobank with Greenstone Biosciences? ??Overcoming weaknesses in current in vitro models with Stemson Therapeutics Like what you see? Reserve your place now whilst our $350 saving is still available. https://ter.li/0htszy???