Two directions of ultrasound therapy: Focused ultrasound ablation & Histotripsy
Recently, there have been many discussions about focused ultrasound ablation and histotripsy, which have aroused the interest of doctors and patients.
The following contents are for reference only. Please consult your doctor for specific questions.
Q
1. Is histotripsy a new technology?
The principle of histotripsy is to focus ultrasound on the lesion inside the body and use the cavitational effects generated by ultrasound to make lesion cells produce tiny bubbles, thus collapsing and breaking to form homogenization. Essentially, it is also a high-intensity focused ultrasound (hifu) technology, not a new technology, but it mostly uses the cavitational effects generated by focused ultrasound.
Q
2. What are the biological effects of ultrasound therapy?
Ultrasound therapy mainly uses the mechanical effects, thermal effects and cavitational effects of ultrasound. Mechanical effects is the primary effect of ultrasound, while thermal effects and cavitational effects are secondary effects. Thermal effects and cavitational effects do not exist independently but account for different proportions. In the course of treatment, coagulative necrosis will occur when heat is dominant, and necrotic homogenate will occur when cavitation effects play the leading role. This is the reason why focused ultrasound ablation can cause coagulative necrosis and histotripsy can cause homogenization after tissue disruption.
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3. Is histotripsy safe enough?
Histotripsy is currently used in clinical studies of patients with liver tumor and renal cell carcinoma, but only a few hundred cases have been reported, and its safety and long-term effectiveness need to be further verified. For example, are there any active cancer cells in the homogenate after tissue disruption? Will distant metastasis occur? Will there be a thrombus in the course of treatment? Focused ultrasound ablation surgery, a relatively mature technology, has treated hundreds of thousands of patients and has been verified by safety and effectiveness studies.
#HIFU #Cancer #Tumor #histotripsy