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Packed house with representation from 50+ companies at this year's AAV Innovation Summit in Raleigh-Durham, NC. A huge thank you to everyone who joined us and for the groundbreaking work you're doing to advance gene therapy! Special thanks to our keynote speaker: Jude Samulski, PhD a true pioneer in AAV gene therapy, and to all our esteemed industry experts who made this event exceptional: Phillip Tai - UMass Chan Medical School Frederick Porter - Taysha Gene Therapies Robin Muthig - Alliance for Regenerative Medicine Adam Cockrell & Paul Herzich - Solid Biosciences Beth Anne Childress, MS, PMP & Nam Tonthat - AskBio Inc. Michael Guerrero & Brooke Brown - BridgeBio Sebastian Aguirre Kozlouski - Carbon Biosciences Elizabeth Tseng, PhD - PacBio Amicia D. Elliott, Ph.D., Anusha Sriraman, Ph.D. & Claire Aldridge - Form Bio Where would you like the next Innovation Summit to be? Boston or the SF/Bay Area? Share your thoughts with us! #GeneTherapy #AAV #Innovation #AI #InSilico

The hidden crisis in biotech development: When good data leads to impossible choices. Manufacturing failures in biotech can stem from two primary sources:? ? Process problems? ? Design problems Process problems are relatively straightforward to address through optimization and adjustment. Design problems, however, require complete re-engineering, consuming valuable time and resources. The real challenge emerges when multiple constructs produce identical data profiles. This creates a decision paralysis that can't be resolved through traditional metrics alone. Companies need robust, multi-dimensional evaluation frameworks to make informed decisions between seemingly equal candidates. Want to hear more great insights from gene therapy experts? Register for the AAV Innovation Summit this Thursday in Raleigh-Durham—only 5 spots left! Register today:?https://lnkd.in/g-Mr9PdK #biotech #AAV #GeneTherapy #Manufacturing

?? Last Chance to Register – AAV Innovation Summit 2025! ?? This event is about to sell out! Don't miss your chance to join Form Bio and top industry & academic experts for a half-day summit on AAV gene therapy innovation. ?? March 20 | 1–5 PM ?? Raleigh-Durham, NC ?? Optimizing genome integrity through AI & vector design ?? Networking reception to follow Secure your spot before it’s too late! Register now: https://hubs.li/Q03bL9fM0 Companies speaking include: Alliance for Regenerative Medicine, AskBio Inc., BridgeBio, Carbon Biosciences, PacBio, Taysha Gene Therapies, Tenaya Therapeutics, UMass Chan Medical School, University of North Carolina at Chapel Hill #AAV #genetherapy #AI #genomeintegrity

Announcing LAAVA 4.0!??? This update enhances integration with other systems and incorporates key user-requested improvements. ?? Check it out on GitHub: https://lnkd.in/gi46vdcp https://lnkd.in/g3EUcZxB

The hidden complexity of viral vectors in gene therapy isn't what most scientists expect. When we package genetic material for therapeutic use, we encounter significant heterogeneity in our final product. This variation comes from three main sources: ? Truncated molecules that don't reach full length? ? Contaminating DNA from the plasmids used in production ? Unexpected genomic DNA from packaging cells Understanding these challenges is crucial for developing effective gene therapies. The quality control process must account for all these variables to ensure consistent and safe treatment delivery. Phillip Tai, PhD, Associate Professor at UMass Chan Medical School will be speaking at the AAV Innovation Summit Mar 20th in Raleigh-Durham. Spots are filling fast—this event is on track to sell out. Register Today: https://lnkd.in/g-Mr9PdK #AAV #AI #genetherapy

??Spots are filling fast—this event is on track to sell out! ?? Join Form Bio for a half-day summit on AAV innovation, featuring leading experts: ?? Jude Samulski, PhD - University of North Carolina at Chapel Hill ?? Phillip Tai, PhD - UMass Chan Medical School ?? Beth Anne Childress, MS, PMP & Nam Tonthat, PhD - AskBio Inc. ?? Paul Herzich & Adam Cockrell, PhD - Solid Biosciences ?? Frederick Porter, PhD - Taysha Gene Therapies ?? Elizabeth Tseng, PhD - PacBio ?? Robin Muthig - Alliance for Regenerative Medicine & more! ?? See the full agenda & register now to secure your spot! https://hubs.li/Q039jxSx0 #genetherapy #AI #insilico #genomeintegrity

The future of computational innovation hinges on one critical factor: massive amounts of data. Traditional biological assays, while reliable, were painfully slow and inefficient, providing just one data point per experiment. Next Generation Sequencing platforms have revolutionized this landscape, enabling researchers to gather unprecedented amounts of data in record time. These advanced technologies allow us to: ? Analyze capsid DNA libraries at scale? ? Study product heterogeneity in detail? ? Examine RNA sequences with remarkable precision? ? Track expression profiles in single cells and tissues This technological leap is particularly crucial for AI and machine learning applications in biological research. The ability to gather and process vast amounts of data is transforming our understanding of biological systems and accelerating scientific discovery. Want to learn more? Join us March 20 in Raleigh for the AAV Innovation Summit:?https://lnkd.in/g-Mr9PdK Early bird pricing ends tomorrow. #AI #AAV #GeneTherapy

Newly Announced Speakers for the AAV Innovation Summit – March 20th Join us at the North Carolina Biotechnology Center (NCBiotech) to hear from: ?? Sebastian Aguirre Kozlouski (Carbon Biosciences) ?? Beth Anne Childress, MS, PMP (Askbio Inc.) ?? Charles Feathers (Tenaya Therapeutics) ?? Paul Herzich (Solid Biosciences) ?? Robin Muthig (Alliance for Regenerative Medicine) ?? Elizabeth Tseng, PhD (PacBio) Early bird registration ends this Friday, February 28th—register now and save $100! ?? Topics include: ? Advancing gene therapy from discovery to clinical trials ? Utilizing long-read sequencing for AAV genome integrity analysis ? Designing AAV vectors with in silico modeling ? Space is limited—secure your spot today to connect with industry leaders and peers! ??https://hubs.li/Q038rrgN0 #AI #InSilico #GeneTherapy #AAV #GenomeIntegrity

Jude Samulski, PhD, Professor & Head of the Gene Therapy Center at UNC-Chapel Hill, will keynote the AAV Innovation Summit on March 20th with a talk on “Advancing Gene Therapy from Discovery to Clinical Trials.” ?? March 20, 2025 | 1–5 PM (Networking reception to follow) ?? NC Biotechnology Center | Raleigh-Durham This exclusive half-day summit unites top industry and academic experts to explore the latest advancements in optimizing genome integrity through AI and vector design. ?? Save $100—Early bird registration ends February 28th! https://hubs.li/Q0379PcT0 #genetherapy #AI #VectorDesign #GenomeIntegrity

AAV Vector Composition More Complex Than Initially Thought Recent analysis has revealed that the initial characterization of AAV vectors can be misleading. For example, what may appear to be 73% single-stranded AAV actually contains a diverse range of molecular species, including full-length vectors (approximately 50%), left, right, and middle partial sequences, and vector plus backbone combinations. The molecular profile also includes snapback genomes, host cell DNA, Rep cap sequences, Ad helper components, and unmapped sequences. Understanding the diverse molecular species present in AAV vectors is essential for improving vector characterization and optimization. Watch the full talk here:?https://lnkd.in/gMYNWCCD Register for our upcoming AAV Innovation Summit in Raleigh-Durham March 20:?https://lnkd.in/g-Mr9PdK