Epilepsia Journal

Key point: A total of 375 patients enrolled in this Dravet syndrome (DS) open-label extension (OLE) study; fenfluramine (FFA) median treatment duration was 824?days (n?=?368). https://lnkd.in/gz8RK2Eb #epilepsy #ilae #antiseizuremedication #seizure

Key point: New evidence points toward a complex interplay between brain and immune system during development. https://lnkd.in/gbHbn4Mv #epilepsy #ilae #braindevelopment #immunesystem #inflammation

Key point: Psychopathology was assessed in 103 pediatric surgical candidates with lesional epilepsy using diagnostic interviews and questionnaires. https://lnkd.in/gie92paE #epilepsy #ilae #behavior #children #epilepsysurgery #outcome #psychopathology

Key point: Interictal epileptiform discharges (IEDs) on routine EEG independently predict increased seizure risk in a cohort of 438 adults with established epilepsy, with a stronger effect in generalized epilepsies. https://lnkd.in/gUrqykhd #epilepsy #ILAE #EEG #prognosis #seizurerecurrence #survivalanalysis #interictalepileptiformedischarge

Epileptic spasms and RNA analysis in a new case of Kabuki syndrome type 2 https://lnkd.in/gV7dBR3s #epilepsy #ILAE #Kabuki #intellectualdelay #Epilepticspasms

We are pleased to welcome our new Editorial Board Members! Meet all of our Editorial Board Members here: https://lnkd.in/g6metBB6 #Epilepsy #EditorialBoard #ILAE #Epilepsia

Key point: Optogenetics induced excessive neural excitation of the hypothalamus projecting toward the mediodorsal thalamus and prelimbic cortex. https://lnkd.in/grCVyzv5 #epilepsy #ILAE #ablationbasedepilepsysurgery #computationalintracranialEEGanalysis #epilepticencephalopathy #epilepticnetwork #optogeneticallyinducedabnormalneuralexcitation

Key point: Following an incident ischemic stroke admission, 78% were initiated on non-enzyme-inducing ASMs, and levetiracetam (42%) was the most dispensed initial ASM. https://lnkd.in/gD933aFX #epilepsy #ilae #antiseizuremedication #ischemicstroke #poststrokeseizure

New Articles in Epilepsia - March 22, 2025 https://lnkd.in/gKkYdXeb #epilepsy #ILAE #newarticles #epilepsia

Key point: Seizures were time restricted to the early or late light (inactive) phase, resulting in higher rates of mortality compared to other times during the light phase. https://lnkd.in/gAqZH4iP #epilepsy #ILAE #physiologicaldecompensation #repeatedseizures #SUDEP