Epilepsia Open Journal

Key point: Anxiety and depression are associated with different subjective memory complaints in people with epilepsy. https://lnkd.in/gCDnNm6y #epilepsy #ilae #epilepsiaopen #anxiety #depression #mood #subjectivememorycomplaints

Key point: Patients included in this EAP had a median history of 22?years of epilepsy, a median of 9 prior failed ASMs, and 41.9% had epilepsy surgery. https://lnkd.in/gXU-tt4C #epilepsy #ilae #epilepsiaopen #antiseizuremedication #cenobamate #responderrate #seizurefreedom

Key point: Hippocampus-dependent spatial memory is not innate and emerges during development through the precisely timed onset of spontaneous activities. https://lnkd.in/gnCVEsvE #epilepsy #ilae #epilepsiaopen #circuit #cognition #development #memory #network #oscillations #placecells #ratecoding #temporalcoding

Key point: Seizures occur in 4.1% of Filipino dementia patients, commonly with Alzheimer's. https://lnkd.in/g6NiMjau #epilepsy #ILAE #dementia #seizure

Key point: Reported the first case of COX4I1 deficiency in China, expanding our knowledge of the mutation spectrum and clinical phenotype associated with this genetic disorder. https://lnkd.in/gPd89ASH #epilepsy #ILAE #COX4I1 #cytochromecoxidase #developmentalregression #intellectualdisability #progressivecerebralatrophy

Key point: We analyzed 8 pediatric patients treated for collagen type IV alpha 1/2 chain (COL4A1/2)-related epilepsy. https://lnkd.in/gWFUXJM3 #epilepsy #ilae #COL4A1 #COL4A2 #epilepsysurgery #seizureoutcomes

Key point: Azetukalner 20?mg once-daily with food yielded long-term efficacy in this open-label extension (OLE) study with 60% retention at 24?months. https://lnkd.in/g9mQayQY #epilepsy #ilae #antiseizuremedication #azetukalner #focalseizure #openlabeltrial #potassiumchannelopener

Key point: This is the first genetic mutation study among photosensitive epilepsy patients in Indonesian populations. https://lnkd.in/d8H4MUaD #epilepsy #ILAE #BRD2 #Indonesian #photosensitiveepilepsy #polymorphism #reflexepilepsy

Key point: Statins do not broadly reduce epilepsy risk but may lower post-stroke focal epilepsy risk. https://lnkd.in/gqtab3cT #epilepsy #ilae #HMGCRgene #LDLcholesterol #Mendelianrandomization #poststrokeepilepsy #statins

Key point: Increased FC in the TAO network is linked to bilateral frontal lobe dysfunction in MTLE. https://lnkd.in/gRnertb5 #epilepsy #ilae #amygdala #frontallobedysfunction #memoryimpairment #orbitofrontalgyrus #psychologicaldysfunction #Yakovlevcircuit