EpiCypher, Inc.

The first #KSGenomeEng25 poster session is almost here! Are you interested in #DNAmethylation sequencing or #multiomic chromatin profiling? Have you wanted to integrate epigenomics into your research, but thought existing technologies were too expensive or incompatible with your samples? We have solutions for you! Stop by Andrea Johnstone's poster #1016 to learn more, or download her poster at the link: https://lnkd.in/eZkjj-Hj

??Will you be attending the Keystone Precision Genome Engineering Conference in Killarney next week? ?? Are you interested in applying chromatin mapping to your genome engineering studies? EpiCypher has solutions for you! Andrea Johnstone will be presenting our new multiomic DNA methylation profiling tech, and we also have assays for high-throughput mapping of histone PTMs, transcription factors, and chromatin remodeling enzymes. Get a sneak peek of her poster at the link below, and reach out if you'd like to speak with Andrea next week to learn more. https://lnkd.in/eZkjj-Hj

?? Long read sequencing + epigenomic mapping = incredible insights into gene regulation for development, disease, plant/agriculture, and more. James Anderson spoke about EpiCypher's latest work in developing #multiomic long read sequencing assays yesterday at #AGBTGM. If you missed it, you can download his poster here: https://lnkd.in/e8E-priz

??EpiCypher is developing new epigenomic mapping tech for long read sequencing platforms! Learn more at #AGBTGM Poster 404 today 2/25 from 4:45-6:10 PM -OR- Download the poster here: https://lnkd.in/e8E-priz

Missed Keith Maier's #AGBTGM poster presentation on low-cost, direct #multiomic mapping of DNA methylation + chromatin proteins? You can still download it here > https://lnkd.in/enY5Di7g

?? We will be on-site at AGBT General Meeting today discussing our low-cost DNA methylation profiling technologies! When: 1:30-2:30 PM, Monday 2/24 Where: AGBT Poster #447 Not at AGBT or simply want to take a closer look? Download our poster at the link: https://lnkd.in/enY5Di7g

Are you attending #AGBTGM? EpiCypher will be there, and we have some exciting chromatin mapping tech to share! How to find us: ?? Keith Maier will be presenting our DNA Methylation & Multiomics Tech at Poster 447 on Monday 2/24, 1:30-2:30PM ?? James Anderson will be talking about our Long Read Sequencing Strategies at Poster 404 on Tuesday 2/25, 4:45-6:10PM ?? Contact Martis Cowles if you want to set up a meeting to discuss anything chromatin mapping or epigenetics related! We'd love to hear about your research.

?? New preprint alert!! EpiCypher is excited to share the results of our collaboration with Deepak Jha, George Q. Daley, MD, PhD Mohamad Ali Najia Margaret Shipp, which identified novel epigenetic targets for diffuse large B-cell lymphoma (DLBCL) therapy. Specifically, this research showed that DLBCL is highly sensitive to KDM4A and KDM4C inhibitors. How does it work? Here is a quick breakdown: ? Inhibition of H3K9 demethylases KDM4A & KDM4C rewires heterochromatin in DLBCL ? Rewiring of heterochromatin induces DNA replication stress cell-intrinsic inflammation ? These changes are highly cytotoxic to DLBCL cells - pointing to an key therapeutic vulnerability ? Bonus! This work leveraged EpiCypher's dCypher? platform for high-throughput screening to characterize novel KDM4 inhibitors. Unlike other platforms, dCypher assays use nucleosomes, which accurately reflect chromatin enzyme activity. https://lnkd.in/ek6xxyn7

?? Breaking news - EpiCypher will be developing Fiber-seq enzymes, kits, and services! https://bit.ly/4hNbnGL ?? First off- what is Fiber-seq? Fiber-seq is a method developed by the Stergachis lab, that allows users to map chromatin accessibility on long-read sequencing platforms. First published in 2020, Fiber-seq has been growing in popularity - especially with the recent publication by the Stergachis lab, leveraging Fiber-seq for multiomic interrogation of Mendelian conditions (https://lnkd.in/dyyPQ4xm). As noted in the Genome Web article, many labs have been starting to implement this tech - from stem cells, to comparative genomics research, and beyond. ?? So where does EpiCypher come in? Our goal is to standardize Fiber-seq and provide kits, enzymes, and services for the scientific community. We want to make this strategy more accessible to help advance epigenetics research! Watch this space...