Entact Bio

Congratulations to?Entact co-founder David Komander?and his team at @WEHI for providing this first-ever view of a key molecular interaction underlying some forms of Parkinson’s disease. The study, published in Science Magazine, could help pave the way for new treatments?for the neurodegenerative disorder. It also highlights the therapeutic potential of targeting ubiquitin-based signaling, an approach that is at the heart of our own efforts to create new medicines for patients with a number of diseases.

As we celebrate #InternationalWomensDay, we recognize the phenomenal teammates, advisors, investors, and industry colleagues who share our dedication to creating new medicines for patients who need them most. Thanks in no small part to these women's extraordinary talents and unflagging drive, we are transcending limits together and expanding the universe of treatable diseases. ?? #IWD2025 #AccelerateAction #WomeninSTEM #drugdiscovery #biotech #precisionmedicine

On this #RareDiseaseDay, the Entact team recognizes the more than 300 million people around the world who live with rare conditions and, in particular, a remarkable patient who joined us at our recent retreat to share her perspective on life with a #RareDisease. ? One point that struck us was the incredibly complex landscape created by diseases that can affect numerous aspects of patients' health and daily living. And because these diseases are rare and clinicians might not have experience treating them, patients often carry an extra responsibility for being expert in their own conditions.? We are awed by the tenacity, smarts, and courage of patients and families who navigate this terrain day in and day out — and inspired to bring the same to our work in creating new medicines to help those with rare diseases have many more, much healthier days.

Attention computational chemists! ?? We recently told you a little about Nicholas Perl, our Senior Director of Molecular Discovery, and how excellent it is to work with him. Good news, then, that we have an opportunity to do just that! If you are an experienced computational chemist and modeler please consider joining Nick in our Molecular Discovery group, where you will have the chance to shape our computational chemistry strategy and our Encompass platform, help to drive programs from hit discovery to hit-to-lead, lead optimization, and development candidate selection — and ultimately help bring life-changing new medicines to patients Full details here ?? Principal Scientist – Computational Chemistry and Modeling https://lnkd.in/exgfTzSx #biotech #translationalbiology #smallmolecules #drugdiscovery #drugdevelopment #precisionmedicine #medicinalchemistry #computationalchemistry #molecular discovery #hiring #biotechjobs #biologyjobs #sciencejobs #startupjobs #jobopening??

Are you a passionate drug discovery leader looking for an opportunity to help lead the development of an entirely new modality poised to change patients’ lives? We're looking for somebody just like you to lead our high-performing Biological Sciences department and help speed the progress of enhancement-targeting chimeric (ENTAC) medicines to the clinic. Check out the details here ?? SVP of Biological Sciences https://lnkd.in/eiY-Yenk #biotech #translationalbiology #smallmolecules #drugdiscovery #drugdevelopment #precisionmedicine #mentoring #hiring #biotechjobs #biologyjobs #sciencejobs #startupjobs #jobopening

We’re delighted to feature Nicholas Perl, our Senior Director of Molecular Discovery for our latest #EmployeeSpotlight ? Nick is a seasoned medicinal chemist and drug discovery leader with deep experience in discovering drug candidates and bringing them to patients. As head of medicinal chemistry, he plays a key role overseeing all chemistry activities and is known to be thoughtful and thorough – someone who leaves no stone unturned when it comes to creating new medicines and supporting his team. Outside the lab, Nick is a dedicated marathon runner, Green Bay Packers fan, and music lover with an expansive record collection. He also bikes to work daily, whatever the weather (no small feat in New England!). ?????? Join us at Entact and work alongside Nick to help develop an entirely new class of medicines for patients who need them the most:? https://lnkd.in/dSRqRK-K

We’re hiring! ???? Are you a computational chemist looking for a meaningful new role, with a team bringing novel therapeutics to the patients who need them the most? Check out our open position ?? Principal Scientist – Computational Chemistry and Modeling https://lnkd.in/exgfTzSx

??? Entackers are a creative bunch, and never is that more apparent than during the holidays. We kicked off the season by sharing favorite family dishes at our Friendsgiving feast and capped it with a lively Yankee Swap and gingerbread house decorating contest. (Having a professionally trained pastry chef on the roster *perhaps* gave the winning team an edge.) All in all it was a wonderful way to celebrate a fun and productive year together, and to look ahead to exciting milestones in 2025. If you'd like to help us achieve those, please check out our open role (pastry-making skills appreciated but not required).?? Principal Scientist – Computational Chemistry and Modeling https://lnkd.in/exgfTzSx

“We know there are so many diseases that are still untreated because of a decrease in beneficial proteins. Our technology has the potential to be a new approach for patients that have those diseases. I’m really excited about what we’re doing at Entact – selecting a specific protein and altering the protein and enhancing its activity [to treat patients].” ?? On the latest episode of the pharmaphorum podcast, our CEO Victoria Richon discusses the vast opportunity of Entact’s patient-driven approach to developing therapeutics that can be applied to virtually all disease categories and needs. ?? Listen here: https://lnkd.in/exQGc55N

?? Meet Fiona O'Brien ??, a co-op from Northeastern University who is making waves in both the biotech world and on the dance stage! Fiona supports our Molecular Discovery team, where she helps develop the assays we use to screen compounds and characterize their ability to enhance protein function. Outside the lab, Fiona is a dedicated dancer, performing with a Boston-based crew across New England. Dance has been her creative outlet since childhood, and she’s proud to keep it alive while building her career. ???? ?? Swipe to discover Fiona’s story and her encouraging advice for those considering a biotech co-op! #biotech #startup #CoOp