Enamine Ltd.

Please welcome Serhii Shuvakin (Серг?й Шувак?н) - the chemist behind the molecule of this week. Congratulations!???? https://bit.ly/4943vO6 #Enamine #molecule #chemistry #science #drugdiscovery

We are excited to share the latest performance results for our Fast MADE Building Blocks! The performance data collected over the past six months for 550 ordered compounds confirms that synthesis deadlines are met to complete orders on time. The Fast MADE catalog contains 96 million molecules, designed for ultra-fast synthesis within 7 to 10 days. This is achieved through 1-3 commonly utilized procedures with an 80% success rate. We remain committed to improving this product by expanding the Fast MADE catalog and optimizing synthesis protocols while maintaining the same rapid turnaround time. Learn more: https://lnkd.in/dB_3HcHM?

Less than 2 Weeks Left to Test infiniSee xREAL! This revolutionary new platform allows you to screen Enamine's xREAL Space with over 2.4?trillion(!) molecules, without the need for external servers or supercomputers. Enjoy full access to its features during our promotion event running until November 30, 2024, plus a?10% discount on ordered compounds. More details:?https://bit.ly/40320NL

Incorporating anionic residues into peptides enhances polarity and facilitates charge-based interactions with target proteins. These residues also improve the water solubility of peptide materials and, in some cases, enhance drug delivery. The standard set of anionic amino acids includes aspartate and glutamate.?Unnatural anionic?residues can further restrict the conformational landscape, strengthen interactions, and reduce metabolic degradation. Enamine offers a collection of anionic amino acids with a range of diverse substituents, including aliphatic, aromatic, and innovative cyclic scaffold-based molecules: https://bit.ly/3UQrJoZ Try our anionic amino acids in your research!

??Exciting surprises are coming your way this December!?? Subscribe to our newsletter for exclusive access to the Enamine Digital Advent Calendar, packed with festive treats and special offers. *The link will be shared exclusively via our newsletter. Don’t miss out - subscribe now: https://bit.ly/3ZbwBb9

Molecule of the week EN300-373718 More details: https://bit.ly/3YSD0ql #Enamine #molecule #chemistry #science #drugdiscovery

We are pleased to announce an update of our fragment library collection: Carboxylic Acid Bioisostere Fragment Library. Designed in collaboration with the leading Medicinal Chemists from ICR, University of London, this pre-plated library aims to be an easily accessible tool for medicinal chemists looking for fast-checking carboxylic acid (CA) alternatives. Key features include: - Covers all reliable CAB replacements with predicted pKa 1 – 14. - Experimentally confirmed solubility in PBS buffer at 1 mM, in DMSO at 100 mM - High diversity within each bioisosteric type - No reactive or unstable compounds, pains free - Analogs from stock and REAL Space available for each fragment We hope this library will be a powerful tool to speed up successful CA isosteric replacement and contribute to the FBDD community. Explore the library to accelerate your research project: https://bit.ly/3YQaUfi

We are excited to share a new paper: “Proline Analogues in Drug Design: Current Trends and Future Prospects”, co-authored by Vladimir Kubyshkin and Pavel Mykhailiuk. ? This study examines fluoroprolines, α-methylproline, bicyclic proline analogues, and aminoprolines, while also highlighting underrepresented proline analogues. The analysis includes physicochemical information regarding the specific molecular properties of these moieties. Additionally, it discusses several intriguing cases where nonproline residues were replaced with proline analogues as a strategy to eliminate unwanted hydrogen bond donor sites, and presents some suggestions for the future exploration of this promising class in drug discovery. ? Read more: https://lnkd.in/gbzgVXXM

Check out the recent paper: “CF?-Cyclobutanes: Synthesis, Properties, and Evaluation as a Unique ????????-Butyl Group Analogue,” co-authored by Volodymyr Ahunovych, Anton Klipkov, Maksym Bugera, Karen Tarasenko, Serhii Trofymchuk, Bohdan Razhyk, Andrii Boretskyi, Oleh Stanko, Yaroslav Panasiuk, Oleh Shablykin, Galeb Al-Maali, Lesyk Dmytro, Oleksii Klymenko-Ulianov, Kateryna Horbatok, Iryna Bodenchuk, Viktoriia Kosach, Petro Borysko, Vladimir Kubyshkin, and Pavel Mykhailiuk. This study presents the synthesis of over 30 small-molecule building blocks featuring the trifluoromethyl-cyclobutyl fragment, achieved by reacting sulfur tetrafluoride with cyclobutylcarboxylic acids on a gram-to-multigram scale. The findings indicate that while the trifluoromethyl-cyclobutyl group exhibited slightly larger steric size and moderately increased lipophilicity, it preserved the original mode of bioactivity in the examined cases and, in some cases, enhanced resistance to metabolic clearance. Read more: https://lnkd.in/d3w6m9qd?

We are happy to share that over the past year, we welcomed numerous student groups for guided visits at Enamine. In total, we hosted 20 tours, providing a behind-the-scenes look at our everyday work and giving future researchers a glimpse into the world of science. It is always inspiring to meet the upcoming generation and share our passion for chemistry and biology. ? We look forward to hosting even more tours in the future! ??