Dovetail Genomics

?? Exciting News! ?? Heading to the Australasian Epigenetics Alliance (AEpiA) conference next week in beautiful Dunedin, New Zealand? ?? Be sure to connect with Brent Thomson, PhD, MBT and learn about how our Dovetail? LinkPrep? assay for Chromatin Topology provides the fastest, most streamlined linked-read protocol available. ?? ?? Generate unbiased and highly accurate genomic-interaction data and take your epigenetic research to the next level by adding 3D genomic interactions to your datasets! Let’s advance the field of #Epigenetics together! ?? Learn more about LinkPrep?: Dovetail Genomics LinkPrep? #Chromatin #3DGenomics #ChromatinTopology #DovetailGenomics #linked-read

???? Congratulations to Dr. Maria-Vittoria Carminati, Esq. and her team on publishing a novel Humpback whale haplotype chromosome-level reference genome in Nature! Using PacBio long-read DNA sequencing, Omni-C technology, RNA sequencing, and mitochondrial sequencing, they were able to achieve the first chromosome-level assembly for this species! Read more about it here: https://ow.ly/RLuJ50U1xQO ????

?? New Blog Alert: Targeting Super-Enhancer Driven Genes in Multiple Myeloma ?? In our latest blog post, we dive into the fascinating world of super-enhancers and their role in driving oncogenic activity in multiple myeloma. ?? Super-enhancers are powerful clusters of regulatory elements that boost gene expression far beyond the capabilities of standard enhancers. In multiple myeloma, these super-enhancers are often hijacked to drive overexpression of key oncogenes, fueling cancer growth. ?? Using advanced techniques like HiChIP, researchers have mapped out these super-enhancer networks and identified PPP1R15B as a critical oncogene activated by this mechanism. Targeting PPP1R15B with the inhibitor Raphin1 shows promising therapeutic potential, disrupting protein synthesis and inducing cell death in myeloma cells. ?? Explore how understanding super-enhancer regulation opens new avenues for targeted therapies, paving the way for innovative treatments in multiple myeloma and beyond. ?? Read the full blog to learn more about these cutting-edge findings and their implications for cancer research here: https://ow.ly/8lv050U5BPZ #CancerResearch #MultipleMyeloma #SuperEnhancers #Genomics #TargetedTherapy #DovetailGenomics #PPP1R15B #HiChIP

More news from Dovetail Genomics! We just announced a $2M SBIR grant from the National Human Genome Research Institute (NHGRI) to further advance our LinkPrep? technology for cancer research. This funding will drive new high-throughput applications for sensitive genomic profiling in oncology, enhancing our ability to detect structural variants in critical cancer samples. Catch us at #ASHG2024 to learn more—visit us at Booth #1148 and join our CoLab session on November 7th at 12:45 PM in Theater 2! View full announcement here: https://bit.ly/4hAeOkL #CancerResearch #Genomics #LinkPrep #ASHG

ASHG Attendees! Join us tomorrow, November 7, at 12:45 pm for our CoLab Talk on somatic variant detection! RSVP here:https://lnkd.in/g5Xcj67D Don’t miss this opportunity to hear from LinkPrep user Brian Walker, Ph.D. and Dovetail Product Lead Cory Padilla, Ph.D. as they showcase how Dovetail’s LinkPrep Technology enhances somatic variant detection with short reads.

??In a recent publication, researchers were able to identify and link potential prognostic markers to disease progression in Acute Myeloid Leukemia. Read more about how Omni-C was used in a multi-omic approach to enable this groundbreaking discovery??: https://ow.ly/i08F50TZM9H #cancer #genomics #omni-c

ASHG folks: Join Us for a Multiomics Happy Hour after ASHG ?? Date: November 7th ? Time: 6:00 PM - 9:00 PM ?? Location: Wynkoop Brewing Company, near Denver’s iconic 16th Street Mall—just a 15-minute walk from the Convention Center or a quick hop on the FREE MallRide bus! Meet and connect with professionals and researchers in the multiomics space. Enjoy an evening of drinks, discussions, and networking in a relaxed setting! All are welcome but let us know you're coming here: https://lnkd.in/gfkfTDRT

If you're at the Advancing Precision Medicine conference in Philadelphia today and want to learn more about our new Dovetail??LinkPrep? Kit and service options for genetic variant detection, you can connect with Misha Gattengo! ??

??Using Omni-C technology, researchers were able to achieve a haplotype-resolved genome assembly of the Japanese red pine (21.7 Gb genome size!). Read more about how this helped enable their research on functional, evolutionary, and breeding-related features??: https://ow.ly/jK7M50TWEHJ #genomics #genomeassembly #plants