Day Zero Diagnostics, Inc

There’s a great new preprint from the team at Copenhagen University Hospital on the utility of genomic surveillance for #InfectionPrevention: ?? Over 28 months, they sequenced isolates from 7,760 patient infections and found that 27.1% were genetically related—meaning they were part of an outbreak. This is all undetected transmission through current IP&C methods!! ?? Using geo-temporal thresholds, they identified epidemiological links in 69% of cases, further supporting the role of transmission within the hospital. ?? Importantly, they modeled the financial impact and found that proactive IP&C interventions based on genomic surveillance could result in €1.25 million in net savings per year. This adds to the growing body of evidence showing that WGS-informed surveillance consistently uncovers transmission at levels traditional methods miss. Despite this, it remains underutilized in infection prevention programs. ?? How much more evidence do we need before it becomes standard practice? ?? Pre-print linked here, and below: https://lnkd.in/ezyUAZPC

This week's World AMR?Awareness Week is a reminder of the urgent need to act now to tackle the escalating global health challenge that is antimicrobial resistance. The Novo Nordisk Foundation is proud to be a funder of CARB-X, a global non-profit partnership accelerating antibacterial innovation by supporting the development of new antibiotics and other life-saving products. ? CARB-X's diverse portfolio includes early-stage antibacterial projects by Day Zero Diagnostics, Inc and Vedanta Biosciences, Inc., which are pioneering innovative tools to prevent, diagnose, and treat the most dangerous drug-resistant bacterial infections. #AMR #WAAW #WAAW2024 #AntibioticAwarenessWeek #AntibioticResistance

The DANGER and IMPACT of the global problem of Antimicrobial Resistance (AMR) has just been re-quantified in an excellent publication in the The Lancet: "Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050". AMR has become - and will worsen - into a catastrophic "silent pandemic". ???????? ???????????????? ?????????????? ???? ?????? ???????? 1990-2021: - While AMR deaths decreased in children under 5 years old, ?????? ???????????? ?????????????????? >80% ?????? ???????????? >70 ?????????? ??????. -?For Gram-negative bacteria, ???????????????????? ???? ?????????????????????? ?????????????????? ???????? ???????? ?????? ?????????? ???????????????????? ??????????, rising from 619K to 1 Million “associated” deaths and from 127K to 216K directly “attributable” deaths -?Regions with the highest AMR mortality rate in 2050 are forecasted to be ?????????? ???????? ?????? ?????????? ?????????????? ?????? ?????? ?????????????????? -?Increases in deaths attributable to AMR in 2050 will be ?????????????? ?????????? ?????????? >70 ?????????? ?????? -?A cumulative 11.1 million AMR deaths could be averted through the development of a Gram-negative drug pipeline addressing AMR pathogens https://lnkd.in/edWBWtRW

Excited to share our latest pre-print on two years of real-time bacterial genomic surveillance for healthcare outbreak detection and mitigation! In this work, we demonstrate that: 1. Weekly bacterial genomic surveillance is not only feasible but impactful. 2. We successfully detected multiple outbreaks early. 3. Directed IP&C interventions. 4. 95% of outbreaks were stopped. 5. We modeled ???? ?????????????????? ????????????????????. ?? 6. All of this led to $??????,?????? ?????? ???????? ??????????????. ?? Our previous retrospective study showed the potential of WGS surveillance for (https://lnkd.in/e-f7QpEu): ? Detecting high-impact outbreaks that often go unnoticed. ? Preventing infections. ? Producing net cost savings. ??????????????, ???????? ?????????? ????????’?? ?????????????????? ???? ????????-????????, ?????? ?????? ???? ?????????????? ????&?? ??????????????????????????. Now, we've shifted to real-time, weekly bacterial genomic surveillance, detecting outbreaks as they occur and alerting IP&C teams. In just two years, we found: ? 3,921 unique infections. ? 476 patients involved in 172 outbreaks. ? Many fascinating outbreak dynamics that we captured early. ? After implementing IP&C interventions, 95.6% of outbreaks stopped along the intervened transmission route. Using a modeling approach & our prior data, we estimated that our interventions ?????????????????? ?????????????????????????? ???? ????????????????????, or 21%—which aligns with prior estimates. The financial impact: The comparison of WGS surveillance costs versus the cost of treating infections resulted in ?????? ?????????????? ???? $??????,?????? ???????? ?????? ??????????. A sensitivity analysis further confirmed that cost savings occurred in 98% of simulations with varying inputs. While there are many important points discussed in the pre-print, ???? ?????????????? ???????? ???????????????? ?????????? ???????????? ???????????????? ???????????????? ?????? ???????????????????? ????????????????????. Current methods often miss outbreaks, while WGS surveillance can not only detect and stop them early but also save money. #healthcare #infectionprevention #genomics Link here or PDF below!: https://lnkd.in/eJpAbgeh

If you happen to be around at ASM Microbe on Saturday, June 15, we invite you to visit our poster: Rapid Species ID and AST Direct from Whole Blood: Initial Results from a Feasibility Study in Patients with Suspected Blood Stream Infection presented by Nicole Billings. #DZD #WGS #rapiddiagnostics #antimicrobialresistance #sepsis