Cyagen

#bignews ????????????? ???????? ???????????????? ???????? ????????-????? ?????????? ???????????? ???? ????????????! Unlock the potential of cutting-edge humanized mouse models to elevate your research in rare and ultra-rare diseases, ophthalmology, neurology, and oncology. Here's why you should apply: ? ?????? ?? ???????? ???????? ???? ?????????????????? ????????:?Valued at $76,000. ? ?????? $????,?????? ?????? ???? ???????????? ????????????????:?Perfect for investigating clinical mutations. ? ???????????????? ????????????????????:?Leverage our TurboKnockout-Pro tech for superior humanization. Focus Areas: ? Ophthalmology ? Neurology ? Oncology ? Rare & Ultra-rare Diseases ???Apply Now:?Submissions are open on a rolling basis, so early applications have an advantage. ?? Application here: https://lnkd.in/gE6jdpA5 Join us in advancing gene therapy research with these state-of-the-art models! #ResearchGrants #GeneTherapy #HumanizedModels #BiomedicalResearch #HUGOGT #cyagen #biotechnology #biotech

#weeklynewsletter ?? Innovative Research in Hyperuricemia and Gout Hyperuricemia, marked by elevated uric acid levels, poses significant health risks, including gout and kidney stones. To support drug development, Cyagen has introduced the?B6-hXDH humanized mouse model, designed to replicate human uric acid metabolism by incorporating the complete human XDH gene, replacing the native mouse version. ???Key Benefits: ??Accurate Modeling:?Ideal for evaluating xanthine oxidase inhibitors (XOIs) and RNA-based therapies. ??Targeted Research:?Provides a platform for developing safer alternatives to current medications like allopurinol and febuxostat. ??Preclinical Advancements:?A valuable tool for advancing our understanding of hyperuricemia and gout. With hyperuricemia affecting over 1.1 billion people globally, innovations like the B6-hXDH model are crucial for discovering effective treatments. #Hyperuricemia #Gout #Research #Cyagen #DrugDevelopment #HUGOGT #scienceandtechnology #researchmatters #researchimpact #biotech

??? Be Part of the 2025 Cyagen Global Partnership Forum! Join us for an exclusive event where global leaders in biotechnology and preclinical research come together to discuss the latest advancements in drug discovery and biomedical science. ?? When: February 26-28, 2025 (PT) | February 27 - March 1, 2025 (Beijing Time) ?? Where: Runxi Hotel, Taicang, Jiangsu, China Why You Should Attend: ? Network with thought leaders and innovators in the field. ? Explore pioneering models like HUGO-GT? humanized mice. ? Discover AI-powered tools for rare disease research and antibody sequencing. ? Get an inside look at Cyagen's cutting-edge facilities. ?? Limited space available! Register now to secure your spot: https://lnkd.in/gXW7B9bZ #globalforum #biotechnology #HUGOGT #Cyagen #biotech #preclinicalresearch #humanizedmice #AI #antibodydiscovery #global #network

?? Transforming Eye and Cancer Research with VEGFA Mice! Discover how VEGFA mice, developed by Cyagen, are enhancing drug testing accuracy and shaping treatment strategies. Vascular endothelial growth factor A (VEGFA) is crucial for blood vessel formation and impacts tumor growth and retinal diseases like age-related macular degeneration (AMD). These innovative humanized and transgenic models allow for precise therapy testing, mirroring human biology. Notably, the RB6 VOM I model maintains normal retinal structure, which is essential for effective research. With new VEGFA-targeting drugs on the horizon, these models are pivotal in advancing treatments for AMD and various cancers. Join the conversation on the future of VEGFA research! ? ?? Learn more about VEGFA mice: https://lnkd.in/grV3H-yG ?? For more YouTube videos please visit here: https://lnkd.in/gGJFKfyX #VEGFA #Research #Ophthalmology #Oncology #DrugDevelopment #HUGOGT #Cyagen #biotechnology #biotech #scienceandtechnology

#researchmatters ? Recent research on CELL from the University of Geneva reveals that tumor-infiltrating lymphocytes, especially CD8+ T cells, follow circadian rhythms that influence tumor growth and the effectiveness of immunotherapy. By timing treatments like CAR-T and immune checkpoint blockade, efficacy can be enhanced. Time-of-day T cell signatures have even been shown to predict survival rates in melanoma patients and response to anti-PD-1 therapy, demonstrating the potential of circadian dynamics to improve clinical trials and patient outcomes. Read more here: DOI:?10.1016/j.cell.2024.04.015 ?? At Cyagen, we’re dedicated to advancing gene-edited cells and animal models. Our experienced team and robust technology platform provide cutting-edge solutions for target gene expression regulation, with a focus on CAR-T and cell therapy research. We offer an extensive catalog of thousands of cell and mouse models for tumor immune research, alongside preclinical pharmacology evaluation services for pharmaceutical companies, biotech firms, research institutes, and hospitals worldwide. One example is our NKG mice model, a severe combined immunodeficiency (SCID) model, which allows for human immune system reconstruction and the creation of various CDX models. ?? Learn more about our Cell & Animal Models for Immune-Oncology and Cell Therapy: https://lnkd.in/gG2XjxGs ?? Learn more about NKG mice: https://lnkd.in/gjQsBfnc #CancerResearch #Immunotherapy #GeneEditing #CART #CellTherapy #PreclinicalResearch #AnimalModels #Pharmacology #Cyagen #HUGOGT #biotech

?? Our Weekly Flash Sales are back for the new year! This week (Feb 17), enjoy amazing savings on mouse models to boost your research. Don’t miss out on these incredible deals! https://lnkd.in/gFSKCDqs Explore our options and secure your models today! ?? #weekly #flashsale #knockout #mousemodel #mice #saletips #HUGOGT #biotechnology #Cyagen #biotech

#mondayvibes Planning a trip? ?? Here’s a handy tip for packing your cosmetics like a pro! ?? Image from Sketching Science #lablife #mondayvibe #phdlife #comics #traveltips #scientists #biotechnology

#weeklynewsletter ??Is Your Love Life Written in Your DNA? ?? In this week's newsletter, you will find the answers. Science just revealed how your genes secretly control: ?? Who you find?irresistible?(blame MHC "scent genes") ?? Whether you’re a passionate adventurer (DRD4 gene at work) ?? Your bonding style (thank OXTR, the “cuddle hormone” gene) Learn more about our research models here: https://lnkd.in/gse5U4UK #valentinesday #scienceandlove #animalmodels #mousemodels #biotechnology #Cyagen #biotech

#happyvalentinesday ?? A Biotech Valentine’s Tribute to Mouse Models & Cells This Valentine’s, we are blending science and poetry to celebrate the unsung heroes of biotech: our tiny cellular collaborators and trusty mouse models! ?? Here’s a little ode to lab love: ??????’???? ???? ???????? ????????, ??’?? ???????? ???????????????? ??????????— ?? ???????????????????? ???????? ???? ?????????? ?????????? ??????????. ?????????????? ???????? ?????????????? ????????, ?????? ???????? ?????????? ????????, ?????????????????????? ?????? ???????????? ?????????? ???????????????????? ??????????????. ???? ???????????????? ???????????? ???????? ?????????? ????’???? ????????????????: ???? ?????? ???????????? ???? ????, ?????????????? ??????????????. ?????? ??????????????????? ?? ?????????????? ??????????— ?????????????????????? ????????, ???? ?????? ???????? ????????????. --------------------------------------------------------- Happy lab-coat romance! ???? To all the researchers, lab warriors, and science romantics out there—may your experiments thrive and your coffee stay strong! ? #valentinesday #love #romance #lablife #mousemodel #scienceandlove #Cyagen #biotech

#obesityresearch ???Unlock New Insights in Metabolic Research with Cyagen’s B6-hINHBE Mice!? Are you studying obesity or metabolic disorders linked to fat distribution and storage? Cyagen’s?B6-hINHBE Humanized Mouse Model?(C001533) offers a cutting-edge tool to accelerate your preclinical studies! Learn more about B6-hINHBE mice here: https://lnkd.in/gyQ-4ERX ???Key Features & Applications: ?? Humanized INHBE Gene: Mimics human metabolic pathways for translational relevance5. ?? Targeted Research: Ideal for investigating obesity, abnormal fat deposition, and related metabolic syndromes5. ?? Precision Data: Supports drug efficacy evaluation and mechanism studies for metabolic disease therapeutics. ???Why Choose Cyagen? ??TurboKnockout? Technology: Faster turnaround (6-8 months) with 100% ESC-derived models and no off-target effects2. ??Trusted Expertise: 15+ years in custom model generation, 78,000+ models delivered, and 6,200+ SCI citations13. ??End-to-End Support: From model generation to phenotype analysis, we ensure reliable data and seamless project execution. ???Get Started Today! Contact us for a quote or consultation to see how B6-hINHBE can enhance your research: ???[email protected]?| ?? 800-921-8930 ???Explore More Models: Cyagen offers a comprehensive portfolio of humanized and disease-specific models for metabolic, autoimmune, and neurodegenerative research. Let’s collaborate to drive breakthroughs! #MetabolicResearch #Obesity #DrugDiscovery #PreclinicalModels #Cyagen #InnovationInScience #HUGOGT #preclinicalresearch #mousemodels #biotech