ChemDiv, Inc.

🌟 Happy International Day of Women and Girls in Science! 🌟 Today, we celebrate the brilliance, resilience, and contributions of women in STEM fields worldwide. From groundbreaking discoveries to pioneering innovations, women continue to shape the future of science, technology, and medicine. 🚀 Did you know? Despite progress, women still make up only 30% of researchers globally. By fostering mentorship, equal opportunities, and representation, we can empower the next generation of female scientists and innovators. 🔬 To all the incredible women and girls in science—your curiosity, dedication, and passion inspire change. Let’s continue to support and uplift each other in building a more inclusive and diverse scientific community. 💡 Tag a woman in science who inspires you! Let’s celebrate their achievements and amplify their voices. #WomenInScience #GirlsInSTEM #InternationalDayOfWomenAndGirlsInScience #STEMLeadership #WomenInSTEM

Just wrapped up an incredible experience at #SLAS2025! It was a fantastic show filled with innovative exhibitors, insightful posters, and great networking opportunities. I truly enjoyed connecting with industry experts, exploring cutting-edge technologies, and discussing the future of life sciences. Looking forward to continuing the conversations and collaborations sparked at the event. Feel free to reach out—let’s keep the momentum going! 

Plan to attend SLAS 2025? Scheduled a meeting with Aleksandra Khotimchenko to learn more about our Small Molecule Diverse Collection for Screening!

ChemDiv, Inc. CEO, Bill Farley, will be attending the J.P. Morgan Healthcare Conference in San Francisco, CA, January 13–16, 2025. This event serves as a premier gathering of industry leaders, offering an unparalleled opportunity to engage in meaningful discussions, explore innovative strategies, and foster impactful collaborations. 💥 If you are also attending, we invite you to connect with Bill Farley to discuss potential synergies and partnership opportunities. 🤝 To arrange a meeting, please reach out directly to Bill Farley.

This Veterans Day we honor the courage, sacrifice, and unwavering dedication of the men and women who have served in our military. We are deeply grateful to our veterans and their families for their commitment and service, which continue to inspire us every day. 💫 Thank you for your sacrifice and bravery 👏

ChemDiv released new update of our screening collection. You can download database that includes over 1.6 million HTS compounds, 70,000 building blocks, 45,000 inhibitors and drugs. With unigue structural diversity, smart design, fresh updates and varios formats available, we keep over 30Y market leadership. ChemDiv ensures resupply, resynthesis, immediate analogs selection, medchem FTE support for H2L. https://lnkd.in/exgt57S7 #screening_collection

ChemDiv introduces a new DarkKinome library of screening compounds. DarkKinome refers to a subset of protein kinases that are less well-studied than their better-known counterparts. These kinases, including BRSK2, CDK10, CDK12, CDK13, DYRK1B, PIP4K2C, PKMYT1, STK17B, TLK2, and WEE2, are characterized by limited structural and functional knowledge, posing challenges for drug discovery. Despite this, they are considered drug targets due to their roles in various signaling pathways and potential implications for diseases such as cancer and neurodegeneration. Target kinases: 1. BRSK2: involved in the regulation of neuronal function. 2. CDK10: plays a role in cell cycle regulation and transcription. 3. CDK12: important for the regulation of RNA polymerase II transcription. 4. CDK13: functions similarly to CDK12 in transcriptional control. 5. DYRK1B: associated with neurodevelopmental disorders and cancer. 6. PIP4K2C: involved in phosphoinositide metabolism. 7. PKMYT1: regulates cell cycle progression. 8. STK17B: involved in stress response pathways. 9. TLK2: associated with DNA damage response. 10. WEE2: critical regulator of the cell cycle. To improve the understanding and therapeutic targeting of these dark kinases, we created a customized chemical library containing potentially active 8436 molecules targeting these targets. The development of this library utilizes machine learning algorithms combined with extensive knowledge obtained from both open and commercial databases including: PubChem, ChEMBL, Google Patents, SciFinder, and others. Using these resources, we selected small molecules with potentially high affinity and selectivity for dark kinome targets. The integration of machine learning enabled prediction of the potency and safety profiles of compounds, improving the efficiency of the drug discovery process. For each of the 10 kinases, we provide a list of compounds. https://lnkd.in/evmNtu3a #DarkKinome 

✨ Yesterday, the ChemDiv, Inc. team had the privilege of attending #InnovationDay2024 in San Diego. The event was packed with engaging panel discussions featuring thought leaders from Johnson & Johnson, UC San Diego, Arcturus Therapeutics, Maravai LifeSciences, Replicate Bioscience, Inc., and more. We were also honored to meet San Diego Mayor Todd Gloria. Connecting with our community leaders and industry pioneers in such a dynamic setting reaffirms our commitment to driving innovation within the biotech sector. 💡 Let’s continue pushing the boundaries of science and innovation—together! #InnovationDay2024 #Biotech #SanDiego #Networking #ChemDiv #BiotechInnovation #CollaborateForSuccess

ChemDiv Presents Over 85,000 Compounds in Five Updated AGRO Libraries Modern agrochemicals and pharmaceuticals interact with their target receptors or enzymes using similar molecular recognition processes. In some cases, they target homologous proteins, making it unsurprising that the same class of compounds can produce active ingredients for both industries. Crop protection research and pharmaceutical chemistry offer an exciting landscape of innovation, driven by a variety of chemical sources and methods. The common principles of molecular recognition reveal opportunities for cross-industry applications, showing that the process from initial screening hits to optimized leads goes beyond traditional boundaries. Our AGRO Libraries include various agrochemical classes such as plant growth regulators (PGRs), herbicides, insecticides, fungicides, safeners, rodenticides, and others. The target space encompasses ALS inhibitors, ACCase inhibitors, auxin mimetics, ACS inhibitors, elongase inhibitors, GGPP cyclase inhibitors, PPO inhibitors, GST stimulators, 14α-demethylase inhibitors, DHP synthase inhibitors, DOXP synthase inhibitors, EPSPS inhibitors, PDS inhibitors, and 4-HPPD inhibitors. We offer a wide and novel chemical space of new potential antibacterial, antifungal, and antiparasite compounds. Our antifungal collection features inhibitors of ergosterol biosynthesis, fungal membrane disruptors, inhibitors of fungal cell wall synthesis, sphingolipid biosynthesis, nucleic acid synthesis, protein biosynthesis, and microtubule biosynthesis inhibitors. Our antibacterial sets are specifically focused on critical bacterial targets, including RNA polymerase, DNA polymerase III, peptide deformylase, cell division protein FtsZ, tyrosine tRNA ligase, penicillin-binding protein, New Delhi metallo-beta-lactamase-1, DNA gyrase, and DNA topoisomerase IV. These targets are essential for bacterial survival and replication, making them ideal candidates for the development of novel antibiotics. #GRO_Libraries https://lnkd.in/eAg5PM4x

🎉 As we celebrate Labor Day, we want to take a moment to acknowledge and appreciate the hard work and dedication of our incredible team at ChemDiv, Inc., as well as all the professionals in the life sciences and drug discovery industry. Your commitment to advancing science and improving global health is truly inspiring. 🎉 Wishing everyone a relaxing and enjoyable Labor Day. Let's take this day to recharge and reflect on the achievements we've made together. #LaborDay #ChemDiv #TeamWork #Innovation #DrugDiscovery