Chem by Cell Press

Check out the March issue of Chem by Cell Press: https://hubs.li/Q03cLB0l0 On the cover: This month's cover illustrates multiplexed luminescence imaging using de novo luciferases. In their study, Chen et al. computationally designed artificial luciferases and expanded a spectrum of color emissions by F?rster resonance energy transfer (FRET) to enable multiplexed in vitro bioassays and in vivo bioimaging. The cover image visually symbolizes this innovation by featuring an Edison-style lightbulb with a luciferase protein filament that emits a vibrant, rainbow-hued glow. This design reflects the dynamic versatility of new luciferase enzymes developed via protein design methods powered by artificial intelligence. Art credit: Gianina Wicaksono and Ian Haydon.

Cell Press editors Gillian Hatzis (Chem by Cell Press) & Marshall Brennan (Device by Cell Press) are heading to the American Chemical Society Spring meeting in San Diego, CA, this weekend and would love to meet with you to discuss your chemistry research. DM them to arrange an in-person meeting.

Online now: Electrochemical 6Li isotope enrichment based on selective insertion in 1D tunnel-structured V2O5 https://dlvr.it/TJf8c5

Cell Press editors Gillian Hatzis (Chem by Cell Press) & Marshall Brennan (Device by Cell Press) are heading to the American Chemical Society Spring meeting in San Diego, CA, this weekend and would love to meet with you to discuss your chemistry research. DM them to arrange an in-person meeting.

Online now: Strained diradicaloids for σ-bond-insertion reactions: A breakthrough in drug discovery https://dlvr.it/TJcyfD

Online now: Electrophilic selenium drives electron leakage https://dlvr.it/TJbnGD

Online now: Cartilage-targeting fluorophores for early detection of arthritis in the NIR-II window https://dlvr.it/TJZcgK

?? Chem's March Issue is lit up! ?? We have a lot to highlight in this new issue, and we're so excited to put the spotlight on this wonderful cover from the group of Andy (Hsien-Wei) Yeh, celebrating their achieve in the use of de novo luciferases for bioimaging! Here's what they had to say about how it relates to their work: "This month's cover illustrates multiplexed luminescence imaging using?de novo?luciferases. In their study,?Chen et al.?computationally designed artificial luciferases and expanded a spectrum of color emissions by F?rster resonance energy transfer (FRET) to enable multiplexed?in vitro?bioassays and?in vivo?bioimaging. The cover image visually symbolizes this innovation by featuring an Edison-style lightbulb with a luciferase protein filament that emits a vibrant, rainbow-hued glow. This design reflects the dynamic versatility of new luciferase enzymes developed via protein design methods powered by artificial intelligence. Art credit: Gianina Wicaksono and Ian Haydon. We also want to shine a light on a few other reports in this issue, namely: ?? A piece from the Yoshizawa group which details the discovery of a helical assembly which can encapsulate achiral dyes and subsequently display CPL behavior. ?? Konrad Tiefenbacher's group at the University of Basel demonstrated site selective sp3-hybridized C—H bond oxidations without the need for specific functional groups on the substrate. ?? The Chilton and Liddle groups at the University of Manchester report a side-on radical trianionic diphosphorus bound uranium species which displays a large degree of magnetic exchange coupling. ?? A piece from the group of Daniele Leonori at RWTH Aachen where they achieved the Birch reduction of naphthalenes via a photoexcitation strategy. ?? A piece we've highlighted from the Braunschweig group at Würzburg where they detailed the bonding and electronic properties of a four-membered cyclic boron species across multiple charged states. Read all of these and more here: https://lnkd.in/eaY3Bezm

Online now: Indocyanine polymethine fluorophores with extended π-conjugation emitting beyond 1,200?nm for enhanced NIR-II imaging https://dlvr.it/TJX06k