Today we’re releasing Chai-1r, an updated version of Chai-1 with full support for restraints. Prompting Chai-1r with prior structural knowledge can boost accuracy by >2x. https://lnkd.in/euP7frVQ Custom restraints can refine predictions with knowledge obtained from scientific literature or lab assays. For example, a “contact” restraint specifies that two tokens are within a certain distance. A “pocket restraint” indicates a token should be in contact with another chain. Chai-1r excels in antibody-antigen interaction prediction with mean DockQ % of - Chai-1r (+4 epitope residues): 43.7 - Chai-1: 35.6 - Boltz (an AlphaFold3 reproduction from MIT & Genesis): 26.4 - AlphaFold2: 20.6 Restraints are available immediately both in our public codebase (https://lnkd.in/e3SGx_dj) and on our web server (https://lnkd.in/e9YfR6GV).
关于我们
Building frontier artificial intelligence to predict and reprogram the interactions between biochemical molecules.
- 网站
-
https://chaidiscovery.com
Chai Discovery的外部链接
- 所属行业
- 科技、信息和网络
- 规模
- 2-10 人
- 总部
- San Francisco，California
- 类型
- 私人持股
地点
-
主要
获取路线
US，California，San Francisco