Cellecta, Inc.

A recent Nature study reveals that ARAF mutations play a key role in resistance to RAF dimer inhibitors like belvarafenib in NRAS-mutant melanoma. These mutations allow tumor cells to evade inhibition, limiting the effectiveness of targeted RAF therapies. What This Means for Cancer Research? - ARAF mutations drive resistance by maintaining kinase activity. - Belvarafenib-resistant cells frequently develop ARAF alterations. - RAF + MEK inhibitor combinations could help delay or overcome resistance. Understanding these mechanisms is crucial for developing more effective targeted therapies. Read more at https://lnkd.in/gSZ-CrFi #MelanomaResearch #CancerBiology #RAFInhibitors #TargetedTherapy #PrecisionMedicine #Oncology #GeneticScreening #Cellecta

Need a cell line tailored to your experiments? Cellecta’s Custom Cell Engineering Service delivers precisely modified cell models, including CRISPR knockouts, knock-ins, reporter cells, and inducible gene expression systems. With validated cell pools and clonal lines, we ensure high-quality, reproducible results, so you can focus on groundbreaking discoveries instead of cell line development. Accelerate your research with expertly engineered cell models. ?? Learn more: https://lnkd.in/gTpr8YFD #CustomCellLines #CRISPR #GeneEditing #CellEngineering #BiotechResearch #Cellecta

Planning a pooled CRISPR/Cas9 screen? The success of your experiment starts with a reliable, high-quality library. Since 2007, Cellecta has been a leader in lentiviral CRISPR library design, providing thousands of researchers with highly validated genome-wide libraries. ?? What We Offer: ? CRISPR Knockout Libraries – Updated human & mouse genome-wide libraries, plus new chicken & pig knockout options ? CRISPRa & CRISPRi Libraries – Single-guide & dual-guide options for both gain-of-function and loss-of-function screens ? Complete Screening Solutions – From Cas9 validation kits to NGS analysis services, we provide everything you need Set up your next CRISPR screen with confidence. Explore our full range of libraries and services today! Learn more at https://lnkd.in/gfhHiRV3 #CRISPRScreening #GeneKnockout #FunctionalGenomics #CRISPRLibraries #BiotechTools #Cellecta

Looking for the best approach to TCR and BCR repertoire analysis? DriverMap? AIR provides precise profiling of immune responses across various sample types. The newly updated Technology Guide V2 covers bulk vs. single-cell analysis, validation barcodes, and key applications for profiling immune diversity with NGS-based solutions. ?? Download the guide now: https://lnkd.in/gs-3nP59 #AdaptiveImmunity #ImmuneProfiling #CRISPR #Genomics #TCR #BCR #Cellecta

This International Women’s Day, we celebrate Jennifer Doudna, a groundbreaking scientist whose work revolutionized gene editing. As a co-developer of CRISPR-Cas9, her research has transformed the fields of genomics, cancer research, and functional screening, enabling scientists to edit DNA with unprecedented precision. Her contributions continue to shape the future of biotechnology, influencing everything from targeted therapies to genetic screening tools—areas where Cellecta’s CRISPR libraries and functional genomics solutions play a key role. ?? Tag a woman in science who inspires you! #InternationalWomensDay #WomenInScience #JenniferDoudna #CRISPR #GeneEditing #Genomics #Cellecta

Maximize CRISPR Knockout Efficiency with A2058-Cas9 Cell Line! Looking for a high-efficiency Cas9-expressing cell line for your CRISPR knockout studies? The A2058-CMV-C9B Cas9 Cell Line offers 96% knockout efficiency by day 11, ensuring precise and reliable gene disruption for your research. Engineered from the A2058 melanoma cell line, this polyclonal Cas9-expressing model is optimized for high-throughput genetic screening and functional genomics applications. ? spCas9 expression with Blasticidin selection ? Validated CRISPR knockout efficiency ? BSL-2 compliant, mycoplasma-free, and available in frozen format Advance your gene editing research today! Learn more: https://lnkd.in/gqVsPfE5 #CRISPR #GeneEditing #Cas9 #FunctionalGenomics #CellLineResearch #Biotech #Cellecta

A recent Cell Genomics study reveals that CRISPR interference (CRISPRi) systems may have more off-target effects than previously understood. Seed sequences in sgRNAs can trigger unintended gene regulation, impacting transcriptome-wide expression. At Cellecta, we develop optimized CRISPRi sgRNA libraries designed to minimize off-target activity and ensure high-precision functional genomics screening. Our validated tools help researchers achieve reliable and reproducible gene silencing with confidence. ?? Explore Cellecta’s CRISPRi solutions and stay ahead in gene editing research: https://lnkd.in/gafsWzwT #CRISPRi #GeneSilencing #FunctionalGenomics #CRISPR #PrecisionResearch #MolecularBiology #Biotech #Cellecta

Engineered Cell Lines, Designed for Your Research Get precisely modified cell lines with Cellecta’s Custom Cell Engineering Service. From CRISPR knockouts and knock-ins to inducible gene activation and inhibition, we provide tailored solutions to accelerate your discoveries. Whether you need edited cell pools or fully validated clonal lines, our expert team ensures high-accuracy modifications to support your research. Transform your experiments with custom-engineered cell lines today! ?? Learn more: https://lnkd.in/gTpr8YFD #GeneEditing #CustomCellEngineering #CRISPR #FunctionalGenomics #KnockoutCells #Cellecta

Meet Cellecta at AACR 2025! We’re excited to be at the AACR Annual Meeting 2025, happening April 25-30 at the McCormick Convention Center in Chicago, IL! Stop by Booth 609 to explore how our CRISPR and functional genomics solutions can advance your cancer research. ?? Let’s connect and discuss the latest innovations in oncology—see you in Chicago! https://lnkd.in/gfTWV-Up #AACR25 #CancerResearch #CRISPR #GeneEditing #FunctionalGenomics #Oncology #Biotech #Cellec

Unlock the Potential of Cellecta’s Advanced Research Tools! Explore how Cellecta’s cutting-edge technology streamlines genetic screening and profiling in our comprehensive overview poster. Whether you're working with CRISPR/RNAi screens, DriverMap? assays, or CloneTracker? barcode libraries, we provide the solutions to enhance your workflows and ensure high-quality results. What’s inside? ? CRISPR/RNAi screening for gene function analysis ? DriverMap? Expression & AIR assays for precise profiling ? CloneTracker? Barcode Libraries for cell lineage tracing ?? Download your free copy today: https://lnkd.in/g2rmDn-q #CRISPRTools #GenomicsResearch #FunctionalGenomics #BarcodeTracking #GeneExpression #Cellecta