Now online! Proteolethargy is a pathogenic mechanism in chronic disease https://dlvr.it/TGQxRj
Cell by Cell Press
期刊出版业
Cell aims to publish the most exciting and provocative research in biology. Posts by Scientific Editors on the Cell team
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Cell, the flagship journal of Cell Press, is a bimonthly journal that publishes findings of unusual significance in any area of experimental biology, including but not limited to cell biology, molecular biology, neuroscience, immunology, virology and microbiology, cancer, human genetics, systems biology, signaling, and disease mechanisms and therapeutics.
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Now online! Trellis tree-based analysis reveals stromal regulation of patient-derived organoid drug responses https://dlvr.it/TGPh2d
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Now online! Mechano-dependent sorbitol accumulation supports biomolecular condensate https://dlvr.it/TGNmSL
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Now online! ACSL4 and polyunsaturated lipids support metastatic extravasation and colonization https://dlvr.it/TGNWFN
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Phenomenal #Proteomics #Biomarkers #TherapeuticTargets #Resource now breaking online at Cell Press | UK Biobank plasma yields comprehensive Open-Access #Proteome ? #Phenome #Atlas | #health | #disease | #diagnostics | Large-scale proteomics studies can refine our understanding of health and disease and enable precision medicine. Here*, the authors provide a detailed atlas of 2,920 plasma proteins linking to diseases (406 prevalent and 660 incident) and 986 health-related traits in 53,026 individuals (median follow-up: 14.8 years) from the UK Biobank, representing the most comprehensive proteome profiles to date. This atlas revealed 168,100 protein-disease associations and 554,488 protein-trait associations. Over 650 proteins were shared among at least 50 diseases, and over 1,000 showed sex and age heterogeneity. Furthermore, proteins demonstrated promising potential in disease discrimination (area under the curve [AUC] > 0.80 in 183 diseases). Finally, integrating protein quantitative trait locus data determined 474 causal proteins, providing 37 drug-repurposing opportunities and 26 promising targets with favorable safety profiles. These results provide an open-access comprehensive proteome-phenome resource (https://lnkd.in/dXGrTCbD) to help elucidate the biological mechanisms of diseases and accelerate the development of disease biomarkers, prediction models, and therapeutic targets. *https://lnkd.in/dJuTcVMg Celentyx Ltd Professor Nicholas Barnes PhD, FBPhS Omar Qureshi Catherine Brady GRAPHICAL ABSTRACT
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Now online! snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification https://dlvr.it/TGL75Y
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Now online! Atlas of the plasma proteome in health and disease in 53,026 adults https://dlvr.it/TGKsdJ
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Now online! Evolutionary genomics of the emergence of brown algae as key components of coastal ecosystems https://dlvr.it/TGJk02
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Now online! Fibroblastic reticular cells generate protective intratumoral T?cell environments in lung cancer https://dlvr.it/TGHtPT Burkhard Ludewig Lucas Onder
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Now online! Glia-like taste cells mediate an intercellular mode of peripheral sweet adaptation https://dlvr.it/TGHdFk