Cell by Cell Press

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Phenomenal #Proteomics #Biomarkers #TherapeuticTargets #Resource now breaking online at Cell Press | UK Biobank plasma yields comprehensive Open-Access #Proteome ? #Phenome #Atlas | #health | #disease | #diagnostics | Large-scale proteomics studies can refine our understanding of health and disease and enable precision medicine. Here*, the authors provide a detailed atlas of 2,920 plasma proteins linking to diseases (406 prevalent and 660 incident) and 986 health-related traits in 53,026 individuals (median follow-up: 14.8 years) from the UK Biobank, representing the most comprehensive proteome profiles to date. This atlas revealed 168,100 protein-disease associations and 554,488 protein-trait associations. Over 650 proteins were shared among at least 50 diseases, and over 1,000 showed sex and age heterogeneity. Furthermore, proteins demonstrated promising potential in disease discrimination (area under the curve [AUC] > 0.80 in 183 diseases). Finally, integrating protein quantitative trait locus data determined 474 causal proteins, providing 37 drug-repurposing opportunities and 26 promising targets with favorable safety profiles. These results provide an open-access comprehensive proteome-phenome resource (https://lnkd.in/dXGrTCbD) to help elucidate the biological mechanisms of diseases and accelerate the development of disease biomarkers, prediction models, and therapeutic targets. *https://lnkd.in/dJuTcVMg Celentyx Ltd Professor Nicholas Barnes PhD, FBPhS Omar Qureshi Catherine Brady GRAPHICAL ABSTRACT

Now online! snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification https://dlvr.it/TGL75Y

Now online! Atlas of the plasma proteome in health and disease in 53,026 adults https://dlvr.it/TGKsdJ

Now online! Evolutionary genomics of the emergence of brown algae as key components of coastal ecosystems https://dlvr.it/TGJk02

Now online! Fibroblastic reticular cells generate protective intratumoral T?cell environments in lung cancer https://dlvr.it/TGHtPT Burkhard Ludewig Lucas Onder

Now online! Glia-like taste cells mediate an intercellular mode of peripheral sweet adaptation https://dlvr.it/TGHdFk