C4 Therapeutics, Inc.

Happy Administrative Professionals Day! Thank you to our teammates Mary Kathryn O., Susan Howard and Katie Sheridan for supporting our team each day – keeping us organized and on track to accomplish great things through #TPD.

New to Deggie’s Room: To celebrate our 10th anniversary we’re looking back at the pivotal moments that shaped C4T – including a seminal brainstorming session that led to the creation of our TORPEDO® platform, a 10,000-compound library and the foundation for a new class of medicines that pushes beyond the limits of existing modalities.    Visit our website to read more, including insights on the session from Christopher Nasveschuk and James A. Henderson: https://bit.ly/42U1y5c #TPD #C4TxTeam

Every decision we make at C4T is guided by our five values – they serve as reminders of who we are, both individually and as a team, and how we come to work each day to deliver transformative #TPD medicines for patients. Together we are courageous, committed, catalysts, compassionate and trustworthy. Learn more on our website: https://bit.ly/3PXUleB #C4TxTeam

Each of our targeted protein degraders can remove many copies of a disease-causing protein rather than just blocking a single protein, as inhibitors do. This means lower concentrations of degraders are needed to create a durable therapeutic effect that lasts even after the medicine is cleared from the body. By degrading disease-causing proteins, we have the potential to fill a gap in current treatment standards for #cancer. Learn more on our website: https://bit.ly/3Q1804k #TPD #cancerresearch 

In honor of our 10th anniversary, we welcomed one of our co-founders, Nathanael Gray, for a Q&A session led by our chief scientific officer Paige Mahaney. Nathanael spoke to our team about the growth of TPD as a new therapeutic modality since he first helped to establish the field, including the progression of innovative drug candidates through discovery efforts and into clinical trials.      We had a wonderful time catching up with Nathanael for a conversation that highlighted how far we’ve come and our potential to make a deep impact for patients.

Colorectal cancer (CRC) is the second deadliest cancer in the United States, according to the American Cancer Society, and impacts both men and women. Current treatment options, including FDA-approved BRAF inhibitors, can lead to resistance with median progression-free survival rates of less than 15 months across CRC and other malignancies with a BRAF mutation.     Our CFT1946 program targets colorectal cancers with BRAF V600 mutations by completely removing the abnormal BRAF protein rather than inhibiting it, potentially leading to better outcomes by overcoming resistance.   Learn more about our program at https://bit.ly/43ygxPi, and find out how to detect and diagnose CRC early at https://bit.ly/4i8hdmx.  #ColorectalCancerAwarenessMonth #colorectalcancer #CRC #cancerresearch #TPD

March is Multiple Myeloma Awareness Month, an opportunity to raise awareness of multiple myeloma – a blood cancer that is difficult to diagnose because it often causes no symptoms before reaching an advanced stage. Some early signs of myeloma include bone pain or weakness, infections or low blood counts. Our cemsidomide program is designed to target IKZF1/3 transcription factors that drive multiple myeloma. Learn more on our website: https://bit.ly/4bsj5TU #myelomaawarenessmonth #multiplemyeloma #myeloma #bloodcancer

C4T leadership will participate in the Leerink Partners Global Healthcare Conference on March 10 in Miami, Florida. #biotech

On International Women’s Day we celebrate the women who drive life-changing progress within biotech, including our own teammates who are pioneering a new generation of #TPD medicines. We thank our colleagues for their dedication to advancing our mission and inspiring each other and others to use their passion for science to reach new heights.   Paige Mahaney, our chief scientific officer, is part of the majority-women executive leadership team at C4T who use their position and experience to encourage younger generations to pursue careers in #STEM. #IWD2025

Happy Employee Appreciation Day to our #C4TxTeam, a group of catalysts who join together each day with a shared motivation to deliver transformative medicines to patients. We’re proud of each member of our team for the role they have played to get us this far - reaching ten years as a company this year. We thank them for bringing their unique selves to work every day and supporting each other to help us accomplish great things. To celebrate our teammates we all received a sweet treat – C4T M&Ms that hold a striking resemblance to our logo! #EmployeeAppreciationDay #biotech