Bruker Fluorescence Microscopy

These images of two-color hippocampal brain slices are AWESOME ?? 150um fixed hippocampus slices from mice transferred with retroviruses for Cre-T2A-EGFP or tdTomato. Taken with Bryan Luikart’s new Ultima 2Pplus multiphoton microscope installed at The University of Alabama Heersink School of Medicine. Enjoy your new system, we can’t wait to see what interesting research you perform with it in your lab! #neuroscience #brain #MicroscopyMonday

???????????????? ?????? ?????????? ???? ???????????? ???????????????? ???????? ?????? ???????????? ??-???????? ?? https://lnkd.in/giWn5WX8 Is your lab already using tissue-clearing techniques, or are you hoping to learn more about this microscopy technique for biological research? Our new e-book is a complete guide to using this essential tool in fields, including #neuroscience, connectomics, #oncology, developmental #biology, and organoid research. This comprehensive e-book will provide you with the knowledge and insights to enhance your research and create compelling data. It discusses: ? Different types of tissue-clearing methods, including hydrophobic, hydrophilic, hydrogel-based, and expansion microscopy techniques. ? Key considerations for choosing the right clearing protocol, such as sample type, size, and compatibility with various labeling methods. ? Cutting-edge methods (light-sheet fluorescence microscopy) can enhance your imaging capabilities. ? Detailed explanations and practical tips for successful tissue clearing from leading scientists ? The potential of tissue-clearing techniques to revolutionize research in future studies

A new article “Cell-type-specific manifold analysis discloses independent geometric transformations in the hippocampal spatial code” has been published in Neuron! Read it here: https://lnkd.in/ejVbPWDb ?????????? ?????????????? and the team from ?????????? ?? ???? ???? ?????????? ?????? at ???????? use dual-color miniscope imaging with the Inscopix, Inc. nVue to uncover how deep and superficial CA1 pyramidal cells encode parallel, independent spatial maps in the hippocampus, highlighting the complexity of hippocampal population dynamics. This is an important study for further understanding how the brain encodes spatial information at the population level. #neuroscience #brain #lifesciences #therapeutics

Are you interested in learning more about the complete Inscopix, Inc. solution and workflow to enable simultaneous calcium imaging and behavioral experiments? ?? https://lnkd.in/d5n-jxMV Matthew Whitmire, PhD, and Morgana Favero, PhD, will be presenting the seminar “Neural circuit interrogation and neurotherapeutic development enabled by the Inscopix solution” hosted by the ???????????? ????????????????, ?????? and ?????????????? ????????????, ??????, will be presenting the seminar “Neural circuit interrogation and neurotherapeutic development enabled by the Inscopix solution” hosted by the National Center for Wellness & Recovery. The presentation will highlight products, applications, and results enabled by Inscopix technology and share some exciting results from the Inscopix Discovery Lab, which is advancing the fields of neurotherapeutics and drug discovery. #neuroscience #therapeutics #drugresearch

?? ???? ???????? ?????? ?????????????? ???? ?????????? ?????????????????? ?????????????? ??????????????? ?? Bruker’s LCS SPIM has unique multi-size cuvettes for all sample mounting procedures. These cuvettes come in 3 different sizes ranging from [20 mm × 20 mm × 20 mm] to [100 mm x 30 mm x 30 mm] to allow imaging of both organs and whole organisms. These cuvettes simplify sample mounting and microscope cleaning and minimize the amount of pricey clearing solution you have to use. All of this occurs while ensuring your sample is kept safe. ?? The cuvettes also ensure the best illumination by moving in z, followed by correcting the focus shift with changes in the detection optics. This feature is well-suited for experiments requiring high detection efficiency, quantification, and speed. LCS SPIM cuvettes come in three sizes equipped for a range of samples, including a mouse brain, rat brain, and whole mouse. #Biology #Lifesciences #Microscopy

?? ???????????? ?????? ?????? ?????????? ???? ??????, ???????? ?? ?????????? ?????? ???? ???????????????????? ?? We had a blast in LA at the annual Biophysical Society Meeting! Thank you for stopping by our booth to learn all about our single-molecule localization microscopy (SMLM) solutions. Our Vutara VXL super-resolution microscope uses SMLM to let researchers explore new cell biology applications, including relating structure, organization, interaction, and stoichiometry to cellular function. Stay connected with our team! Abraham Kohrman #lifesciences #cellbiology

?? ?????? ???????????? ???????????? ?????????????????????? ???????????????????? ?????? ???????????? ???????????????????? ?????? ?? ?????????? ???? ???????????????????????? ???? ????????????????????????. ?? Whether it’s intravital imaging of tissues or 3D optogenetic manipulation, this microscopy technique helps researchers uncover discoveries in their labs. ?? Depth-colored projection of neurons in cleared mouse brain slice. #lifesciences #neuroscience #MicroscopyMonday

?? ???????? ???? ???? ???????? ???? ?????? ???????????? ???? ???????????????????????? ???????????????????? ?????? ?????? ???????? ????????????????!?? ?? https://lnkd.in/dxs23iDE As a dedicated researcher, you know the importance of staying updated with the latest advancements in our field. Subscribe to our mailing list and be the first to know about Bruker's latest products, events, and innovations. Customize your subscription to receive updates tailored to your interests. #lifesciences #microscopy #neuroscience

Have you read the article, “Functional specificity of liquid-liquid phase separation at the synapse” by ?????????????? ??. ???????????????????? and ?????? ??. ????????????????? ?? https://lnkd.in/dgs8yASw In their recent paper, Guzikowski and Kavalali demonstrate that liquid-liquid phase separation is an important mechanism to ensure precision in synaptic transmission. Their methods include a combination of conventional microscopy, electrophysiology, and single-molecule localization microscopy with the Vutara VXL super-resolution microscope. This article was featured in our Fluorescence Microscopy Journal Club. If you would like to be notified of other featured publications once a month, you can subscribe here: ?? https://lnkd.in/duq2Qm2b ?? dSTORM Munc13 single molecule localizations at an individual bouton color coded based on density heat map. #neuroscience #cellbiology

?? Happy Valentine’s Day ?? Our fluorescence microscopy solutions are used to explore important topics in neuroscience, cellular biology, and virology, but our visualization tools are also great for creating visuals for a holiday of love! The single-molecule localization data below are idylle U2OS cells color-coded for depth. The video was taken with the Vutara VXL Super-Resolution Microscope’s SRX software. SRX software lets researchers quickly and easily localize, visualize, and analyze their imaging data with tools including, spatial distribution, cluster analysis, and live cell analysis. Enjoy the day! #ValentinesDay #neuroscience #cellbiology