Bruker Cellular Analysis

?? New Application Note for Cell Line Development Researchers! ?? Are you working with bispecific antibodies and looking to streamline your cell line development process? Our latest Application Note demonstrates how to identify high-quality bispecific antibodies in just days using the Beacon? platform with SpotLight reagents! In this Application Note, you'll discover how to: ? Identify top clones early, with optimal growth, titer, and product quality attributes—before scale up. ?? Screen a broad range of cell lines, including those expressing traditional mAbs and complex formats like bispecific antibodies with Lambda-Kappa light chains. ? Accelerate the identification of cell lines producing molecules in the desired format, cutting down development timelines. Download now: https://hubs.ly/Q02VG6JR0 #CellLineDevelopment #AntibodyResearch #BeaconPlatform #BiologicsDevelopment #BiotechInnovation #BispecificAntibodies

It’s been an incredible week in Sydney, Australia where I had the opportunity to give a talk on my research during the Tumor Immunology session at the 52nd Annual Meeting for the Australian and New Zealand Society for Immunology (ASI)! A major hurdle in developing TCR-T cell-based immunotherapies for the treatment of cancer is our insufficient knowledge of what drives immunogenicity. The goal of my research project is to comprehensively assess the factors contributing to differences in tumor immunogenicity across different classes of antigens and define the principles of CD8+ T cell immune recognition that shape these responses. Interestingly, we found that the number and diversity of the neoantigen-specific responses varied between both the types of antigens and donors tested. I’m excited to continue leading this research to help develop improved cell-based immunotherapies for patients with cancer. I would like to thank Drs. Anthony Zamora and Ravi Shah for their contributions to this work, the team at Bruker Cellular Analysis for their continued support, and the ASI NSW Organising Committee for the opportunity to present our findings. #cancer #research #Tcells #immunology #immunotherapy #immunooncology #collaboration

Pick any paper. If it involves the protein, nucleic acid, secreted content or behavior of prokaryotic or eukaryotic cells, there's likely a subsection describing how those cells were grown in culture - whether in petri dishes, multi-well dishes, flasks or 96-well plates. Cell culture is how researchers expand cell clones and colonies to harvest macromolecules, enrich specific phenotypes or to interrogate their responses to changing biological conditions or chemical treatment. Integral to such work is the unquestionable assumption that all the cells in a dish will be identical— so by growing and interrogating them in culture, the researcher is simply isolating and amplifying the signal. Right? - But is this always true? - Might subtle differences at genotypic and even phenotypic levels yield significant variation in cellular behavior which may be averaged out across the population? - Could these differences have significant downstream impacts long-term on the stability of your master cell bank, binding affinity of your biologic or either rapid exhaustion or cytotoxic cytokine profile of your activated T cell? Until recently researchers had no way to probe this variability. Today, they do: The Beacon Optofluidic System - with single cell cloning and constant perfusion - provides targeted, accurate and sensitive profiling of single cell identity and behavior for 1000s of cells over the life-time of each cell. Visit Bruker Cellular Analysis to learn more! #bruker #brukercellularanalysis #beacon #celllinedevelopment #tcellprofiling #antibodydiscovery #optofluidic #optoelectropositioning

??Happy Thanksgiving from Bruker Cellular Analysis ?? This Thanksgiving, we're filled with gratitude for our incredible community of scientists, researchers, and partners who inspire us every day. As we reflect on the year, we're thankful for the opportunity to work together in pushing the boundaries of discovery and making breakthroughs possible. From all of us at Bruker Cellular Analysis, we wish you a joyful Thanksgiving filled with family, friends, and gratitude. ?? #Thanksgiving #Grateful

Leverage the Opto Assure? Aggregation Assay to assess product quality early in clone selection, reducing risks of protein aggregation and improving outcomes. By evaluating aggregation risk early, you enhance therapeutic reliability and minimize development delays. Explore the app note: https://hubs.ly/Q02Zt1MQ0 #Biotech #CellLineDevelopment #ProteinAggregation #Pharma

Un grand merci à Paris Saclay Cancer Cluster (PSCC) pour son accueil chaleureux et l’opportunité de présenter #Beacon, Bruker Cellular Analysis' plateforme multiomique innovante pour la caractérisation fonctionnelle en temps réel des cellules immunitaires vivantes et la découverte d’anticorps. Cette rencontre a été une formidable occasion d’échanger sur les avancées technologiques qui fa?onnent l’avenir de l’immunologie et de la recherche thérapeutique. ?? Un merci également au Prof. francois romagne de MImAbs SAS pour sa brillante présentation sur l’utilisation de Beacon dans la découverte d’anticorps. ?? Retrouvez le replay et la présentation diffusée lors de cet événement sur Paris Saclay Cancer Cluster (PSCC): https://lnkd.in/eNvfwgnA #Merci #Innovation #Multiomique #Immunologie #DécouverteAnticorps #Collaboration #TechnologieDePointe #Recherche #PSCC #CART Fabienne Tardieu

Missed our recent webinar with Dr. Joseph Zenga from the Medical College of Wisconsin? You can now watch it on-demand! In "Advancing Single-Cell Methods in Solid Tumor Oncology with Bruker’s Optofluidic Platform," Dr. Zenga unveils groundbreaking research on tumor-infiltrating lymphocytes (TILs). In this webinar we discuss: ?? Establishing a single-cell co-culture system to identify and visualize interactions between cancer cells and T cells in real-time ?? Measuring tumor-specific TIL functionality and tumor-killing capacity from biopsies obtained from HNSCC patients ?? A powerful strategy to generate new immunotherapies by identifying the TCR sequence of functional TIL cells Watch on-demand today ? https://lnkd.in/gZbE-zAC #CancerResearch #Immunotherapy #TILs #SingleCellAnalysis

?? The Beacon platform reduces CLD timelines by up to 30%, allowing rapid selection of high-performing clones. With integrated assays for monoclonality, growth, productivity, quality, and stability, you can achieve faster, more efficient workflows. Discover more ?? https://hubs.ly/Q02Yxt9h0 #CellLineDevelopment #Biotechnology #Pharma

?? Equipment spotlight ?? The Beacon Optofluidic system from Bruker Cellular Analysis is a high precision clonal isolation technology. Visit our website https://lnkd.in/e4GEzAyM to read a CONCEPT case study featuring this equipment.

Want to accelerate your cell line development timeline? Deliver lead clones in six weeks. In our latest blog, we explore how Bruker Cellular Analysis' Beacon? Cell Line Development platform is helping teams reach the finish line faster. By enabling lead clone selection in as little as six weeks, the Beacon platform is reshaping the timeline for cell line development and bringing life-changing therapies closer to patients. Read how at https://hubs.ly/Q02Y8rz20 #Biotechnology #Biologics #CellLineDevelopment #BeaconPlatform