Broad Institute of MIT and Harvard

In recognition of her groundbreaking scientific discoveries that have changed the understanding of cancer biology, Cigall Kadoch, PhD, has been named as the Laureate of the Blavatnik National Awards for Young Scientists in the field of life sciences. The award from the Blavatnik Family Foundation and The New York Academy of Sciences is given to America’s most promising, faculty-level scientific researchers under age 42. Kadoch was selected by an independent jury comprised of some of America’s most distinguished scientists out of 331 nominations from 172 institutions that were received by the 2024 Blavatnik National Awards committee. https://lnkd.in/eEwSu8-N

Burlington’s life sciences continue to grow with the major addition of Broad Institute of MIT and Harvard https://lnkd.in/evpU5K65 Bring Me to Burlington Burlington Area Chamber of Commerce MassBio

Broad’s expansion to Burlington, Massachusetts is official! We built the new home for our Genomics Platform and Broad Clinical Labs from the ground up, and this week we cut the ribbon! For the past 20 years, Broad Institute has called Kendall Square home, and while that remains unchanged, we’re excited to open this highly-advanced facility in Burlington. We were thrilled to have Massachusetts Governor Maura Healey, Secretary of Economic Development Yvonne Hao, Representative Ken Gordon, Burlington Town Administrator Paul Sagarino and many others from across the Commonwealth on hand for the opening ceremony. It was a privilege to have you celebrate this milestone with us, and we are appreciative of your support! Broad’s Genomics Platform has led the field for more than 20 years. As one of the world’s largest producers of human genomic data, we provide critical insights into the genomic basis of diseases, enabling our understanding and treatment of complex conditions. Our teams contribute to landmark projects such as the Human Genome Project and the Cancer Genome Atlas, and building COVID-19 testing capabilities for K-12 schools across Massachusetts and institutions of higher education across the northeast United States. Our goal is to understand why diseases happen, and develop therapies that target these underlying causes. This new facility will significantly enhance our sequencing capabilities and capacity, enabling us to deepen our contributions to advancing science and improving human health. “What’s magical about Massachusetts is that when we work together as a team, we’re unstoppable,” said Secretary Hao. “We’re number one in education. We’re number one in innovation,” said Governor Healey. “We’ve got so much going for us.” We agree! We are proud to be located in Massachusetts, proud to be opening up our new site in Burlington, and proud to be Broadies! Photo Credit: Anthem Multimedia #BroadInstitute #BroadClinicalLabs #BroadGenomics #BurlingtonMA #KendallSquare #Genomics

Tuberculosis (TB) remains a major global health challenge — an existing vaccine offers limited protection, and disease risk after vaccination, prior infection, or exposure varies. Investigating TB reinfection in non-human primate models, Josh Bromley, Sharie Keanne Ganchua, Sarah Fortune, Alex K. Shalek, JoAnne Flynn, and colleagues found that immunological priming by prior, antibiotic-treated TB infection restricts bacterial growth in a CD4+ T cell-dependent manner, with CD4+ T cells acting to regulate inflammation. The results provide insight into new therapies and vaccines for TB. #BroadInstitute #Science #ScienceNews #Research #ScientificResearch

Here’s another peek behind the scenes on #RewritingCancer. There’s just a week to go until the series launches! This series lifts the curtain on the ups and downs of lives affected by cancer and reveals the incredible work happening every day as people work to diagnose, treat, and alleviate cancer. #RewritingCancer is presented by BBC StoryWorks and features Count Me In's commitment to partnering with patients to advance research on September 24.

The factors that govern if and where cancers spread elsewhere in the body, or metastasize, are not fully known. In Nature Metabolism, Sharanya Sivanand, Matthew Vander Heiden, and colleagues profiled both primary and metastatic pancreatic tumors and found that they had metabolic similarities, such as in how the tumor cells processed glucose and glutamine. They also found that cells from both primary and metastatic tumors proliferated more easily in their primary site. The findings suggest that metabolic and nutrient conditions in a tumor's tissue of origin influence the metabolism of both primary and metastatic tumors, which in turn could influence where tumors metastasize. #BroadInstitute #Science #ScienceNews #Research #ScientificResearch

Statistical fine-mapping helps narrow down a list of GWAS hits to a smaller set of potentially causal genetic variants and works well on data from relatively homogeneous populations. Kai Yuan, Tian Ge, Hailiang Huang, and colleagues have developed a technique, SuSiEx, for cross-population fine-mapping. The method integrates data from multiple ancestries, models population specific allele frequencies and linkage disequilibrium patterns, and can be applied to GWAS summary statistics. In Nature Genetics, the team showed how SuSiEx improved fine-mapping for various traits in both the UK Biobank and Taiwan Biobank and the fine-mapping of schizophrenia loci across East Asian and European ancestries.? #BroadInstitute #Science #ScienceNews #Research #ScientificResearch

In this Q&A, Steven Carr and Claudia Ctortecka from Broad’s Proteomics Platform discuss recent advances in spatial and single-cell proteomics which, combined with information from other -omics areas, can provide a more comprehensive picture of cellular activity from gene expression to post-translational modifications. “The advances that have occurred over just the past few years in the field of proteomics, while astonishing, are just a prelude to what is likely to come over the next few years,” Carr said. ?? https://lnkd.in/eJKrfdnn #BroadInstitute #Science #ScienceNews #Research #ScientificResearch #Proteomics

For 50 years, scientists have pondered why variants in the gene HLA-B27 increase a person's risk of developing spondyloarthritis and similar rheumatic conditions by up to 200-fold. In a Cell Chemical Biology review, Eric Brown, Phuong Nguyen, and Ramnik Xavier discuss recent advances in the search for how environmental triggers such as the microbiome could interact with HLA-B27 to initiate rheumatic disease. Variants in the gene change the shape of its protein's peptide binding groove and may set off an autoimmune response involving CD8+ T cells, which can trigger inflammation depending on the metabolic context. The authors suggest future research using computational modeling to predict peptide interactions. #BroadInstitute #Science #ScienceNews #Research #ScientificResearch #Microbiome #Arthritis

Thanks for the feature, The Innovation Trail of Greater Boston! Visit us at the Broad Discovery Center Thursday - Saturday, 10 am to 5 pm. Learn more: https://lnkd.in/dcupeqQh #BroadInstitute #BroadDiscoveryCenter #CambridgeMA