BPS Bioscience Inc.

Have us measure the activity of your PARP or PARG inhibitors in cells. A dependable solution for evaluating compound potency in a biologically relevant system. #DrugDiscovery #CellBiology #LifeSciences Check it out here: https://hubs.ly/Q03dxMrD0

UM171 Identified as Molecular Glue Targeting CoREST Complex to Enhance Haematopoietic Stem Cell Renewal In a recent paper, Yeo et al have elucidated the molecular mechanism behind the action of the small molecule UM171, which is being studied for promoting the self-renewal of haematopoietic stem cells. The study reveals that UM171 binds to KBTBD4, a substrate of the CUL3–RING E3 ubiquitin ligase, as well as the HDAC1/2-LSD1–CoREST complex, facilitating its degradation. By acting as a molecular glue, UM171 targets CoREST for proteasome-mediated degradation, effectively reducing stem cell attrition. #stemcells #drugdevelopment #molecularglue Check it out here: Yeo, M.J.R., Zhang, O., Xie, X. et al. UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors. Nature 639, 232–240 (2025). https://hubs.ly/Q03d8_S40

We are pleased to announce our attedance in the 6th Annual TCR-Based Therapies Summit in Boston. Join our team as we delve into the latest advancements and innovations in TCR-based therapies. This summit provides a valuable opportunity to engage with industry leaders and explore the future of therapeutic solutions. We look forward to insightful discussions and collaborations. See you there!

Metabolic Reprogramming Enhances T Cell Functionality Immunometabolism has emerged as a significant area of research to improve the efficacy of adoptive cell therapy. In this study, Pretto et. al. conducted a comprehensive CRISPR screen of CD8+ T cells across tumor sites to identify metabolic factors influencing T cell functionality to overcome the hostile tumor microenvironment. Through single-cell RNA sequencing, they identified Elongation of Very Long-chain fatty acids protein 1 (Elovl1) as a critical metabolic target. Inhibiting Elovl1 led to SREBP2 activation and destabilization of INSIG1, shifted T cell energy use from glucose to fatty acid oxidation, increasing mitochondrial fitness and allowing the T cells to withstand metabolic stress induced by tumor suppressive signals from tumor cells. In animal models of cancer, this approach improved outcomes when combined with anti-PD-1 therapy. Check it out here: Pretto, S., Yu, Q., Bourdely, P. et al. A functional single-cell metabolic survey identifies Elovl1 as a target to enhance CD8+ T cell fitness in solid tumours. Nat Metab (2025). https://hubs.ly/Q03c4JdQ0

Advancing Bispecific Immune Engagers with Precision Assays Check it out here: https://hubs.ly/Q03bw2l-0

This groundbreaking Nature study reveals how aspirin may help prevent cancer metastasis by limiting platelet TXA2’s suppression of T cell immunity. The drug acts via inhibition of cyclooxygenase 1 (COX-1). This study offers new insights on potential new ways to block metastasis. A fascinating read for anyone in biotech, oncology, or immunology! Check it out here: https://hubs.ly/Q03b6Dxm0 Yang, J., Yamashita-Kanemaru, Y., Morris, B.I. et al. Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity. Nature (2025). | CC BY 4.0

Cutting-Edge Drug Discovery Tools Accelerate Immune Disease Treatment. Check it out here: https://hubs.ly/Q039Y6qS0

Will your smartwatch save your life in the future? A machine learning algorithm in your watch could automatically detect when your heart stops, and call for help. Check it out here: Shah, K., Wang, A., Chen, Y. et al. Automated loss of pulse detection on a consumer smartwatch. Nature (2025). https://hubs.ly/Q0390H6m0

Happy Tuesday! Come check out the BPS Bioscience booth at the Life Science Exhibits Research Supplier Product Show at Icahn School of Medicine at Mount Sinai! Come chat and see how we can support your research! ???? #drugdiscovery #scientificresearch

The FDA just approved inclisiran, which uses RNA interference to decrease the expression of PCSK9 and lower LDL levels. RNA-based therapies that target cholesterol metabolism in the liver may someday replace statin drugs. Check it out here: https://hubs.ly/Q037-wms0