BioTechniques

February may be a short month, but that doesn’t mean we published any less fantastic content! Catch up below ?? NEWS ?? Why do some AML patients respond better to immunotherapy? >>> https://lnkd.in/eMq99vQ3 ??? The biotech bi-weekly: redefining molecular precision with circular dichroism microspectroscopy and enhancing in silico drug discovery >>> https://lnkd.in/enHVXreA ??? Recreating the tumor microenvironment with 3D bioprinting technology >>> https://lnkd.in/ep5MBEyF ?? How does the body respond to parasitic infections? >>> https://lnkd.in/eDQCMeEG ?? Mitochondria of memory: the mitochondrial process supporting social recognition >>> https://lnkd.in/dZmxrMn7 ??? Does age impact the effects of intermittent fasting? >>> https://lnkd.in/e5bgZeNW INTERVIEWS & OPINIONS ?? An AI update: deep learning-based molecular de novo design in drug discovery >>> https://lnkd.in/e7gnMHdc ?? Our top picks of ABRF 2025 >>> https://lnkd.in/eV28MEMP ?? Black scientists’ contributions to research throughout history >>> https://lnkd.in/eiawgfwK ???? Stories, resources and communities to explore for International Day of Women and Girls in Science 2025 >>> https://lnkd.in/dVnfqNzy JOURNAL UPDATES ?? Latest articles >>> https://lnkd.in/evuNMHf9 #BTNMonthlyHighlights

Engineers from EMBL have enhanced the speed and efficiency of imaging with Brillouin microscopy, offering a quicker and more precise method to explore the mechanical properties of samples in 3D >>> https://lnkd.in/eCkUSnA5 Carlo Bevilacqua ???“Over the years, we have progressed from being able to see just a pixel at a time to a line of 100 pixels, to now a full plane that offers a view of approximately 10,000 pixels.” Robert Prevedel

In this Peek Behind the Paper, Morgan Hiebert from the National Microbiology Laboratory branch of the Public Health Agency of Canada | Agence de la santé publique du Canada discusses an RNA extraction and sequencing method for conducting transcriptomic analysis of M. tuberculosis. ??? “…we present a comprehensive, step-by-step wet-lab and computational protocol for performing [RNA-seq] on Mycobacterium tuberculosis. The method encompasses the entire process, from RNA extraction, rRNA depletion and cDNA library preparation, to high-throughput sequencing and differential expression analysis.” Get a behind-the-scenes look at Morgan’s recently published paper in BioTechniques, as well as her top tips for conducting differential expression analyses and what direction this research will take in the future >>> https://lnkd.in/enEUUGVu

Researchers at Icahn School of Medicine at Mount Sinai have developed a computational model that can predict synergistic drug combinations >>> https://lnkd.in/eVJKKEhy Bin Zhang ??? "By leveraging computational approaches like iDOMO, we can prioritize the most promising drug combinations for further experimental validation, potentially accelerating the discovery of new treatments for a wide range of diseases." Xianxiao Zhou

Despite the contraceptive pill being introduced in the 1960s, we still know relatively little about the pill’s effects on the brain. Join Nafissa Ismail, Caitlin Taylor and Belinda Pletzer on 4 March 2025 15:00pm GMT, as they dive into the scientific complexities of this topic and why it’s essential to expand research in this area. >>> https://hubs.ly/Q0367lHD0

For Rare Disease Day 2025, we highlighted three wide-reaching national programs navigating the human genome and its place in rare disease research, as well as recent publications discussing techniques that have been used to understand rare diseases?>>> https://lnkd.in/eDi3cgW5

??? Intermittent fasting benefits have been found to be age-dependent, a novel hybrid microscope can simultaneously image the full 3D orientation and position of molecules within cells, and the latest biotech industry updates. ?? Plus, don't miss our recently published SLAS2025 conference report from Zyme Communications Ltd and an interview with the SLAS Scientific Director. ?? Looking for your next read? In our latest eBook, we explore next-generation sequencing methods and their applications in neurological and cancer research!

A research team from the Norwegian University of Science and Technology (NTNU) have utilized an emerging method, known as the Total Oxidizable Precursor (TOP) assay, to identify PFAS in birds. This method revealed higher levels of PFAS than previously recorded and suggested the presence of unidentified PFAS >>> https://lnkd.in/eq_NYWS6 Veerle Jaspers???“We need to find out more about the sources, but also the effects of PFAS on wading birds, other animals and humans.”

Didn’t make it to #SLAS2025? Don’t worry, Zyme Communications Ltd were your eyes and ears, sharing their industry updates in this conference report https://hubs.ly/Q038zQ180

Traditional periodic sampling methods for cell culture analysis fall short, offering limited data and requiring labor-intensive manual sampling. In this Application Note, discover how PHC Corporation of North America's LiCellMo? was used to: ??Continuously monitor glucose and lactate levels in Jurkat cell cultures ?? Validate the accuracy and stability of PHCbi’s proprietary in-line sensor technology Download the Application Note now >>> https://hubs.ly/Q034lQKG0