BioIVT

Understanding potential obstacles in the selection, utilization, and processing of #FFPEtissue is imperative for successful next-generation #sequencing (NGS). Formalin-fixed, paraffin-embedded (FFPE) #biospecimens provide a cost-effective, versatile resource for NGS applications. NGS can analyze genomes, epigenomes, and transcriptomes and has been considered a valuable method for analyzing molecules derived from FFPE tissue blocks. However, awareness and effective management of the limitations associated with FFPE samples, coupled with optimized library preparation, are fundamental for the successful clinical implementation of FFPE-derived NGS. Read more: https://lnkd.in/gpUZaFmT #Mutations #Diagnostics #Biomarkers #Bioinformatics #PrecisionMedicine

Dissociated #tumor cells (DTCs) contain lymphoid cell subsets, such as #Tcells, B cells and NK cells, which can be easily isolated using standard immunomagnetic selection. As such, they are an invaluable source of tumor-infiltrating #lymphocytes (TILs), which are of critical interest for cellular therapies targeting solid tumors. View the results of an analysis on BioIVT’s DTCs to assess the TIL populations therein including a breakdown of CD45+ populations across a variety of tumor types: https://lnkd.in/eFzWHgR4 BioIVT provides a wide range of tissue and isolated cellular preparations from a diverse donor population. View available #biospecimens here: https://lnkd.in/e7BrxFuB #ImmuneCells #CellTherapy #Oncology #CancerResearch #DrugDevelopment

Kevin King, BioIVT’s Senior Director of #Donor Center Strategy and Growth will be providing his industry insight and expertise by moderating a roundtable session at the 2nd Annual Donor Selection & Source Summit today entitled “Mitigating Risks in #CellandGeneTherapy: Re-evaluating Donor Selection and Characterizing Cellular Starting Material". The discussion will include topics like: ? Establishing industry standard criteria for donor eligibility and implementation of advanced screening technologies. ? Characterization of cellular properties and standardized assays to assess donor derived cell quality and function. As experts in providing RUO & GMP cellular starting and ancillary materials for the manufacture of #AdvancedTherapies, our aim is to foster collaboration between stakeholders to share needs as well as provide input on implementing risk mitigation strategies and foresight for sourcing donor-derived cellular starting material. Make sure to connect with Kevin and Lisa Kretzschmar, MBA if you will be at the event. If you are not attending the event, you can contact our experts here: https://hubs.ly/Q02Ywbkk0 Or view a recording of one of our previous expert roundtables here: https://hubs.ly/Q02Yw96w0 And access other insightful reference materials here: https://hubs.ly/Q02Ywf510) #CellTherapy #GeneTherapy #ATMPs

Our team is having a blast at #ACTOX2024! Visit Robert Taylor, Andrew Taylor, Matt Odom, & Katherine Osborn at booth #505 to discuss all of your #ADME-#Toxicology #biospecimens or service needs! #Hepatocytes #Microsomes #DrugMetabolism #DrugInteractions #Bioanalysis

Antimicrobial resistance (AMR) is an urgent global health threat, causing over 1.27 million deaths worldwide and nearly 35,000 deaths in the U.S. each year. During Antibiotic Awareness Week, we recognize the need for innovative solutions to combat drug-resistant infections. A recent study explored how a natural substance, thanatin, can kill certain harmful bacteria by disrupting a key part of their defense system. Building on this, researchers developed new antimicrobial peptides that target Gram-negative bacteria like E. coli and K. pneumoniae with a reduced risk of resistance. BioIVT contributed essential plasma samples for this study, supporting critical advancements in AMR research. Learn more about this promising approach: https://hubs.ly/Q02Ywc1X0 #AntibioticAwarenessWeek #AMR #AntimicrobialResistance

Our team is excited to be at #ACTOX2024 booth #505 and ready to discuss how we can help accelerate your research! Whether you need #hepatocytes, subcellular fractions, recombinant enzymes or other #biospecimens or need #bioanalytical support and fit-for-purpose studies or consulting for your program, we offer unparalleled expertise to help you understand the #ADME properties and DDI risks of your compound. Stop by to meet with our expert team, including Robert Taylor, Andrew Taylor, Matt Odom, & Katherine Osborn! #DrugMetabolism #DrugInteractions #DMPK #Bioanalysis #Toxicology

Meet Kenneth R. Brouwer, Ph.D., RPh. — VP of Technology, #ADME-TOX at BioIVT! He began his career in Michigan as a registered pharmacist before earning a PhD in Pharmaceutical Sciences at the University of Kentucky. Kenneth’s passion for #pharmacokinetics and understanding how drugs work in the body fueled his journey deeper into #drugdevelopment and research. With a diverse and inspiring career, Kenneth’s top advice for young scientists is simple: “Learn as much as you can and try to enjoy what you're doing.” He strongly believes in balancing both generalization and specialization in order to provide opportunities to grow and flexibility to follow your passions. After all, it is this belief that has allowed him to wear so many hats in his own career. Want to know more about Kenneth? Check out our latest #MeetTheScientist blog: https://hubs.ly/Q02X9P0q0 #Leadership #CareerAdvice #EmployeeSpotlight #Growth

In a recent publication, researchers at BioIVT used #HEPATOPAC cultures to replicate aspects of #MASLD and hepatic steatosis. These studies support the use of HEPATOPAC as a long-term functional #invitro model of #liverdisease having utility for compound screening, drug #toxicity evaluation, and assessment of gene regulation. Read the report: https://hubs.ly/Q02XJ4WB0 #Hepatocytes #DiseaseModels #GeneExpression

Did you miss our webinar on navigating the complex regulations to ensure ethical and regulatory compliance when using human #biospecimens? No problem! The recording and slides are now available: https://lnkd.in/ed7r_XzG Watch our expert team discuss important details on: - Informed Consent, Transparency, and Privacy/Confidentiality - Data Integrity, Data Privacy, and Data Protection - Onboarding Diligence, Auditing and Monitoring - Harmonizing and Integrating Regulatory SOPs and Policies - Regulatory and Ethical Review - Noncompliance and Deviations Access the recording and slides here: https://lnkd.in/ed7r_XzG #Compliance #RegulatoryAffairs #EthicalResearch #Bioethics

People with #diabetes have twice the risk of heart disease, and recent research sheds light on factors that may be contributing to this increased risk. A study in Nature explores how diabetes intensifies heart cell death through a process called #ferroptosis—an iron-dependent form of cell death linked to lipid damage. This study compared heart tissue from diabetic heart failure patients to healthy controls and identified ferroptosis as a significant factor in heart damage. These findings offer valuable insight into the molecular mechanisms driving diabetic heart failure and highlight potential therapeutic targets to help mitigate this risk. BioIVT is proud to have supported this research by providing de-identified human heart tissue samples—along with detailed donor data including age, sex, and other relevant demographics—helping to advance our understanding of diabetes and heart disease. Explore the full research: https://hubs.ly/Q02XJ4Wv0 #DiabetesAwarenessMonth #DiabetesResearch #HeartDisease #MedicalAdvancements