Bioelectronics Drop

Breaking barriers in the treatment of #spasticity after SCI ?? Spasticity, a common complication of spinal cord injuries, stems from impaired inhibitory circuits in the spine, affecting daily life significantly. Now, researchers led by Karen Minassian and Ursula Hofstoetter from the Medical University of Vienna have shown that transcutaneous spinal cord stimulation (TSCS) can restore inhibitory spinal circuits, alleviating spasticity in individuals with spinal cord injury. TSCS inhibits pre- and postsynaptic inhibition noninvasively. Learn more about this work in Cell Reports Medicine https://lnkd.in/ep_wCFWr

The Secret to Regeneration? It’s in the Axolotl Genome Axolotls, native to Mexico’s Lake Xochimilco, have captivated scientists for their extraordinary regenerative powers. These remarkable salamanders can regenerate not just limbs but also organs like eyes, lung tissue, and even parts of the brain and spinal cord. Recently, researchers at Yale, led by Parker Flowers, uncovered two key genes that play a role in axolotl regeneration. This breakthrough in navigating the axolotl’s massive genome—10 times the size of a human’s—opens up exciting possibilities. Unlocking these genetic mechanisms could lead to breakthroughs in human medicine, providing new hope for advancements in healing and tissue regeneration. The study of axolotls brings us closer to understanding regeneration at a genetic level, potentially transforming future medical treatments. #Regeneration #Axolotl #Genetics #HumanMedicine #BiomedicalResearch #TissueRegeneration #GenomeResearch #ScientificDiscovery #YaleResearch #LifeSciences #MedicalInnovation #HealingScience #Biology #GenomicBreakthroughs #FutureOfMedicine

New paper in Med by Cell Press investigated alterations in limb ownership and motor planning in stroke patients, revealing a tendency to integrate incongruent visual feedback about their affected limb into motor plans and feel ownership for it https://lnkd.in/eRSNMEU3 Using a probabilistic causal inference model, these alterations were attributed to proprioceptive deficits, with frontoparietal network damage further disrupting higher-level multisensory integration processes. Understanding the components of body ownership alterations in stroke patients can inform tailored rehabilitation strategies to address these deficits effectively. Giulio Mastria ? Tommaso Bertoni ? Henri Perrin ? Nikita Akulenko ? Gaia Risso ? Michel Akselrod ? Eleonora Guanziroli ? Franco Molteni ? Patric Hagmann ? Michela Bassolino ? Andrea Serino CHUV |?Lausanne university hospital, University of Lausanne HES-SO Valais-Wallis Sense Innovation & Research Center Valduce Hospital “Villa Beretta” Rehabilitation Center #StrokeRehabilitation #LimbOwnership #MotorFunction #MultisensoryIntegration #ProprioceptiveDeficits #FrontoparietalNetwork #Neurorehabilitation #BodyOwnership

Endocisternal?minimally invasive #neural interfaces ? In a first-of-its-kind demonstration, researchers from The University of Texas Medical Branch and Rice University led by Peter Kan and Jacob Robinson implanted a wireless neural interface through a cistern, a space filled with CSF that provides an alternative to endovascular delivery. They also showed neuromodulation, recording, and explantation! Article (and videos) published in Nature Biomedical Engineering https://lnkd.in/eAJhVvGv

Constructing organoid-brain-computer interfaces for neurofunctional repair after brain injury https://lnkd.in/efkmK6Yd

Brain-Tongue interfaces???? The tongue has many neural endings that may be damaged in case of injury, burns, or cancer. Publishing in Nature Communication, researchers from Chinese Academy of Sciences propose a soft gustatory interface that maps the tongue and deciphers tongue electrophysiological activities of subjects suffering from #cancer. Article available open access at Nature Portfolio: https://lnkd.in/e3qRzQx5

A #wearable for cells? ?? Developing microscale soft interfaces that interact wirelessly with may offer new experimental and clinical tools. Publishing in Communications Chemistry, researchers from Massachusetts Institute of Technology led by Marta Airaghi Leccardi and Deblina Sarkar developed a patch that, under illumination can wrap neuronal axons down to a radius of curvature of 250?nm without damaging them Article available open access at Nature Portfolio https://lnkd.in/eq7Fv3kV

Microbatteries for microimplants? ?? Tiny devices require small batteries. Publishing in Nature Chemical Engineering, researchers from University of Oxford led by Hagan Bayley propose a soft, rechargeable Li-ion droplet battery constructed from self-assembling lipid-supported silk hydrogel droplets. They show that, ex vivo, it can power the electrophoretic translocation of charged molecules between synthetic cells Article and videos at Nature Portfolio: https://lnkd.in/enCSFKvd

Flower-shaped platforms for #organoid electrophysiology ?? Probing the electrical activity of a spheroid is difficult because of its fragility and 3D shape. Now, researchers at EPFL and Haute école du paysage, d'ingénierie et d'architecture de Genève - HEPIA led by Eleonora Martinelli and Stephanie Lacour developed a soft platform that "hugs" the spheroid and allows accurate electrophysiological recordings https://lnkd.in/eNxQ67vM

Our webcast discussing the state of clinical trials of implantable brain–computer interfaces is now available on YouTube! The related Review article is available here: https://lnkd.in/e68vptGa Check it out: https://lnkd.in/eVWUEUR6