Biopact is a Molecular Rebar Design Company focusing on nanoscale biomaterials company developing the MGMR intracellular delivery vehicle. MGMR is a cellular-engineering tool for biomanufacturing and agricultural processes which value efficient delivery of RNAs, peptides, and genetic materials. MGMR is a highly-efficient intracellular delivery vehicle, consisting of a stabile dispersion of hollow, nanoscale tubules approximately 1/10,000th the width of a human hair. The high aspect-ratio, nanoscale profile of MGMR allows it to readily penetrate cells without compromising membrane integrity or inducing cytotoxicity. Its high surface-to-volume ratio and tunable surface chemistry allow it to readily transport both small and large-molecular payloads into the cytoplasm, including growth factors, oligonucleotides, proteins and gene-editing complexes. Biopact has evaluated the cytotoxicity profile of MGMR across multiple cell-lines and investigated safety and efficacy in murine biodistribution and clearance models. Our in vivo studies demonstrate that MGMR is biologically-inert, well-tolerated and rapidly cleared from non-targeted tissues. In a murine therapeutic model, MGMR loaded with doxorubicin (Dox) demonstrated a remarkable capability to rapidly concentrate drug in targeted tissues and extend half-life of its molecular cargo. Promising assessments of intracellular delivery performance in different eukaryotic cell-types suggest the potential for developing MGMR as a biomolecular delivery vehicle for various expression platforms and cell-factories of interest to agricultural and industrial applications, including mammalian cell-lines, yeasts, bacteria and plants. Robust cellular uptake observed with MGMR offers the potential to deliver molecular payloads to difficult-to-penetrate cell-types or those acutely sensitive to detergents and other conventional methods for transmembrane delivery.
BioPact的外部链接
12310 Trail Driver Street
US，Texas，Austin，78737
BioPact转发了
Let the pitches begin! What an inspiring group of companies that are sharing their passion and innovations for the future of healthcare and bioscience. BioPact BobiHealth Field Viewers Inc. @Forged Applied Science And Technology Freyya @Humanate Digital @illumaras @kowa NeuraStasis @phage refinery Qana Therapeutics Revi Life Sciences Salutaris Medical Devices VitaBone Medical, Inc.
What is the future of drug delivery? The team at our company has been actively formulating a solution to a complex issue, utilizing our proprietary carbon nanotube-based delivery system, MGMR. We are proud to announce that just yesterday, our dedicated experts – Kevin Castillo, Aaron Tasset, Milos Marinkovic, and Aaron Foote, Ph.D. – have made their years of research on Discrete Multiwalled Carbon Nanotubes (MWCNTs) for drug delivery publicly available. Their groundbreaking study has been featured in the esteemed C-Journal of Carbon Research. This advance opens up new possibilities for more precise and controlled drug delivery mechanisms, potentially revolutionizing treatments for various diseases. We are eager to continue driving innovation in this area, and we invite you to delve into the article detailing our research and celebrate this achievement with us. Your support fuels our mission of delivering transformative healthcare solutions. Join us in congratulating Kevin, Aaron, Dr. Marinkovic, and Dr. Foote for their exemplary work – an inspiring reminder that persistent efforts lead to impactful outcomes. #Innovation #Science #Healthcare #Research #CarbonNanotechnology #MGMR #DrugDelivery https://lnkd.in/g7KGrrX2