ATCC

In vitro screening for neurotoxicity requires cell models that effectively mimic central nervous system (CNS) cell types, particularly neuronal cells. SH-SY5Y neuroblastoma cells have been a mainstay of neurotoxicity research since their development. The utility of SH-SY5Y cells in neurotoxicity research is underlain by their ability to differentiate to neuron-like cells. When undifferentiated, these cells resemble immature catecholaminergic neuronal cells, producing the neurotransmitters dopamine and norepinephrine. After differentiation, SH-SY5Y cells demonstrate significant neurite outgrowth, apparent synapse formation, and expression of many mature neuronal markers (Tau, NF-H, MAP2, TUJ1, and NeuN). Depending on the protocol used, these cells can be differentiated towards adrenergic, dopaminergic, glutamatergic, and cholinergic neuronal phenotypes, enabling their use in disease models, developmental studies, and drug screens. As a result, these cells are a powerful tool to study CNS cellular responses, both in their undifferentiated and differentiated states. Learn more: https://ow.ly/RIUu50VlAtq

Liver disease is responsible for more than 2 million deaths each year, making up 4% of all global fatalities. The use of in vitro liver culture models is highly sought after for investigating liver diseases, toxicology studies, and drug development. In our recent #blog, we'll explore the fundamental properties of hepatocytes and delve into the processes of isolating, cryopreserving, and culturing these vital liver cells. We will also provide an overview of ATCC’s new hepatocyte product, HepatoXcell?, and explain how we stand out from the other hepatocyte providers. Read our blog now: https://ow.ly/u1t050VlwCm

ATCC? ACS-1028 ? cells were used in a recent groundbreaking study that demonstrated the development of cardioids. These cardiac organoids provided a sophisticated model for studying cardiotoxicity, offering insights into the electro-metabolic interactions within human heart tissue. The findings from this study highlight the potential of iPSCs to revolutionize toxicology by providing more accurate and human-relevant data. This ability to generate patient-specific cells makes iPSCs invaluable for personalized toxicology studies, allowing researchers to predict individual responses to substances more accurately. Induced pluripotent stem cells (iPSCs) are transforming toxicology by providing a versatile and human-relevant platform for assessing the safety of new drugs and chemicals. iPSCs can be derived from adult cells and reprogrammed to differentiate into various tissue types, including lung, liver, neuronal, and cardiac tissues. Overall, high-quality iPSCs are essential for advancing toxicology research and improving the predictive power of in vitro models. By using iPSCs, scientists can create more physiologically relevant models that better mimic human responses, reducing the reliance on animal testing and enhancing the efficiency of the drug development process. Learn more: https://ow.ly/ECY150VkXAW

?? Celebrating 40 Years of Partnership! ?? We are thrilled to mark the 40th anniversary of our collaboration with Summit Pharmaceuticals, our esteemed official distributor in Japan. This milestone represents four decades of shared success, innovation, and commitment to excellence in providing high-quality products and services. Thank you to Summit Pharmaceuticals for being an invaluable partner. Together, we look forward to many more years of growth and achievements! #Anniversary #Partnership #ATCC #SummitPharmaceuticals #Japan #Innovation #Success

Check out today's poster presentation at the #SOT2025 Stop by poster board number LB287 to hear from presenters Sujoy Lahiri, PhD, Lead Scientist, ATCC & Eline Geervliet, PhD, Application Scientist, Locsense. Learn more: https://ow.ly/XlFV50VlpyV

Today is the last day of #SOT2025 #ToxExpo Chat with our experts at booth #1161 to learn about our new HepatoXcell? primary human hepatocytes. Learn more: https://ow.ly/Igx950VkNeS

Join our presentation today at the #SOT2025 Learn about a novel microphysiological model designed to mimic the gut-hepatic barrier that utilizes ATCC HepatoXcell Primary Human Hepatocytes and Caco-2 cells. The model employs the Locsense Artemis instrument to measure transepithelial electrical resistance (TEER), providing insights into barrier integrity. This study highlights the model's potential for advancing our understanding of gut-liver interactions, offering a robust platform for drug testing and toxicity studies. ??Join us today in room W208C from 1:45pm-2:45pm Learn more: https://ow.ly/gHiP50VjYtH Sujoy Lahiri & Susan Roelofs

?? APPW2025 Luncheon Seminar Highlights ?? We had an incredible time at the APPW2025 luncheon seminar in Tokyo! With over 120 attendees, the event was a huge success. Dr. Ruth R Cheng was our esteemed speaker, and the seminar focused on the impact of biology on life sciences. The discussions were insightful, and the networking opportunities were invaluable. Thank you to everyone who joined us and made this event memorable. Stay tuned for more updates and photos from APPW2025!

We're in Orlando for #SOT2025! Visit us at booth #1161 to learn about our new HepatoXcell? primary human hepatocytes that support predictive drug development and toxicity testing. Learn more about toxicology portfolio: https://ow.ly/EjT750Vjfh6

Check out today's poster presentation at the #SOT2025 #ToxExpo! Stop by poster number D236 to hear from Xiangshan Zhao, PhD, Senior Scientist, ATCC. Learn more: https://ow.ly/ec1f50Vj9PT