Aligning Science Across Parkinson’s | ASAP

Funding reminder - LOIs for the Scientific Track open in January 2025 ?? This competitive funding initiative aims to accelerate breakthroughs in #ParkinsonsDisease research by supporting high-risk, large-scale projects. Funded teams will join the international and multidisciplinary Collaborative Research Network, a community of investigators working together to answer critical research questions and drive new discoveries.? Learn more and apply today: https://bit.ly/3YL2hCA #CRNFundingOpportunity #grants

The relative distributions and proportions of neurotransmitter-defined cell types across VTA and SNc remains unclear. In their recent publication, Team Awatramani used fluorescent in situ hybridization to label VTA and SNc neurons encoding VMAT2, VGAT, and VGLUT2. ?? These data complement recent single-cell RNAseq studies and support a more diverse landscape of neurotransmitter-defined cell types in VTA and SNc than is typically appreciated. Read the full #publication to get the details: https://lnkd.in/edSqEdhs

We are celebrating Amanda Schneeweis from CRN Team Awatramani as our November Network Spotlight?? Amanda planned and hosted an ASAP Social at the 2024 Society for Neuroscience Conference in Chicago that brought together people from several ASAP CRN Teams. "To some degree, we are all familiar with each other's scientific work," Amanda said. "Opportunities like this create a space to connect with each other on a human level - learning about hobbies, interests, and lives outside of the lab. Importantly, it also brings together all levels: trainees to faculty. I think connecting with each other in this way only enhances the desire to collaborate and benefits the mission of open science." Thank you for all your hard work, Amanda!

We are celebrating Justin Savage from Team Calakos as our #OpenScience champion for his development of SynBot, an open-source image analysis software for the automated quantification of synapses ?? Justin shared the source code, tutorials, tissue processing protocols, and example data for his tool. In addition, the manuscript associated with SynBot was compliant with the ASAP Open Science Policy at the preprint stage. Check out Justin's SynBot: https://lnkd.in/eQeVDFtw

In their recent publication, CRN Team Surmeier's findings suggest that disruption of mitochondrial function and the subsequent bioenergetic deficit is a proximal step in the cascade of events induced by aSYN pathology leading to dysfunction and degeneration of neurons at risk in #PD ?? Check out their recent #publication: https://lnkd.in/eK_fnMVA

Regulator of G-protein signaling 10 (RGS10), a key homeostatic regulator of immune cells, has been implicated in multiple diseases associated with aging and chronic inflammation including #ParkinsonsDisease (PD) ?? In this preprint, Team Liddle analyzed RGS10 levels in the proteomic database of the CSF from PPMI. Interestingly, they found that subjects with idiopathic PD display reduced levels of RGS10 in subsets of peripheral immune cells. Check out the full #preprint: https://bit.ly/4giYvaX

In the latest Building Up the Nerve podcast from National Institute of Neurological Disorders and Stroke (NINDS), Sonya Dumanis, PhD, ASAP’s Deputy Director, discusses practical advice for securing research funding, a critical topic for scientists at every career stage ?? ?? Sonya, along with panelists Kat Steele, PhD, and Gene Yeo, PhD, MBA, shares invaluable insights on: ?? Selecting the right funding opportunities ?? Effectively pitching your research to funders ?? Crafting compelling grant applications Whether you’re a researcher navigating funding challenges or looking to enhance your science communication skills, this #NINDSNervePod episode is packed with tools and advice to empower your career. ?? Don’t miss out—listen here: https://bit.ly/4i3TvbC

We convened researchers from across the Middle East and Africa in Morocco last week for our GP2 Regional Investigators Meeting – the first meeting we’ve hosted in the region! We thank everyone who helped make the meeting a success, and we’re looking forward to more collaborations to advance our knowledge of #PD ??

Today at 1 pm ET ?? Loukia Parisiadou PhD, from #NorthwesternUniversity, is presenting at the November LRRK2 Central #webinar. It's not too late to reserve a spot using the link below. https://lnkd.in/gam6sAUp ???Thursday, November 24 ? 1:00 pm ET

We are pleased to announce the latest installment of the Discover ASAP video series featuring Justin Savage from Team Calakos! This series is designed to disseminate key findings, datasets, protocols, and tools developed within the ASAP network. Watch the latest interview here ??: https://bit.ly/4fZwS6x #OpenScience #ParkinsonsResearch #PD