AmberGen转发了
AmberGen is proud of its tradition of scientific innovation and a big part of that is the work done by our innovative scientists such as Leonardo Garcia Dettori, PhD. Leo did a great job on this foundational project where he demonstrated that the "soft ionization" associated with MALDI Mass Spectrometry does not destroy or consume a sample, leaving it available for subsequent imaging steps as part of a spatial multiomic workflow. Nice work Leo! #MALDI #IMSIS #ASMS
Biochemist | Molecular Biologist | Bioinformatics Scientist | Spatial Biologist | Structural Biologist | Bioprocess Engineer
I recently had the opportunity to represent AmberGen and present a poster at the American Society For Mass Spectrometry (ASMS) annual meeting this month. The poster reports a workflow we call 'Cyclic MALDI-IHC’. AmberGen’s Miralys? MALDI-HiPlex-IHC is used to simultaneously image hundreds of intact proteins on a tissue section, tissue microarray, or single cells. The Cyclic MALDI-IHC workflow consists of reusing the same tissue section for successive imaging: (i) with the same panel of probes resulting in nearly identical images across cycles demonstrating this is a non-destructive workflow; (ii) with the same panel of probes at higher spatial resolution to image specific?regions of interest; (iii) or image even with a completely different panel of probes to obtain?additional biological information from precious samples. While this poster demonstrates successive cycles of MALDI-IHC, it also opens the doors for other multiomic and multimodal workflows?(e.g., lipids, small molecules, drugs, transcripts)?on the same tissue section. If you would like to learn more, contact us at AmberGen.com ([email protected]). I am very grateful for the guidance of the scientific team at AmberGen including?Prof. Kenneth Rothschild, Dr. Mark Lim, and Dr. Gargey Yagnik as well as our CEO, John Gillespie! ? #ASMS #MSI #spatialbiology #neuroscience #multiomic #multimodal #proteomics