Alpenglow Biosciences

?? Exciting times in the world of 3D Spatial Biology! We're thrilled to share that Alpenglow Biosciences has been recognized as an up-and-coming leader in spatial biology! https://lnkd.in/g8BmBsF2 ?? With our pioneering approach to 3D imaging and spatial data analysis, we’re unlocking unprecedented insights into tissue biology and pushing the boundaries of biomedical research. ?? A recent feature in Nature spotlights 3D Spatial Biology, underscoring its unique ability to reveal complex cellular interactions in ways that 2D imaging simply cannot match. This transformative approach reshapes our understanding of disease mechanisms, diagnostics, and treatment pathways, setting new standards for precision and insight. https://lnkd.in/e-p-Rnws We’re proud to be part of this exciting movement—and we’re only getting started! ?? Meet us at the upcoming SITC Annual Congress to explore how our technology can drive deeper insights, improve therapeutic outcomes, and empower the next breakthroughs in precision medicine. https://lnkd.in/dBkpipiC #SpatialBiology #3DBiology #AlpenglowBiosciences #LifeScienceInnovation #SITC

Happy Thanksgiving from Alpenglow Biosciences! Wishing everyone a season of gratitude, joy, and continued success.

There are a few days left! Don’t miss our groundbreaking poster presentation at #MultiOmics2024, where we’ll unravel the complexities of immune cell dynamics through advanced 3D tissue-scale analysis. ???Poster Title:?3D Tissue Scale Automated Segmentation with Alpenglow 3Dai Spatial Analysis Suite ???Poster ID:?#119 ???Presenter:?Jasmine Wilson, Principal Data Scientist, Alpenglow Biosciences Our poster presentation, led by Jasmine Wilson, Principal Data Scientist at Alpenglow Biosciences, delves into how cutting-edge 3Di? light-sheet microscopy and the 3Dai? Spatial Analysis Suite revolutionize immune cell research. This innovative approach provides unprecedented insights into neutrophil morphology and function within intact tissues, overcoming the limitations of traditional 2D histology. By automating the segmentation of key cellular structures, our methods open new pathways for understanding immune responses in complex biological systems. Catch us at Poster #119 and discover how 3D spatial biology transforms the field. Let’s drive innovation together at Multi-Omics Brisbane 2024!

We are deeply grateful for the unwavering support and belief in Alpenglow's mission. Your encouragement fuels our passion to innovate in #SpatialBiology, advancing its transition to 3D for a more comprehensive understanding of biological systems. Thank you for highlighting this exciting recognition from Genetic Engineering & Biotechnology News https://lnkd.in/dWsKiWJW —it’s a testament to the hard work and dedication of our incredible team. Together, we’re making strides toward a brighter future in scientific discovery. Here’s to continued growth, innovation, and impact!?

? Happy #FluorescenceFriday! ? Check out this stunning 3D video of human normal adjacent colorectal cancer FFPE tissue, straight from our SITC poster! For the technical experts, here’s the breakdown: ?? Tissue Prep: FFPE tissue was deparaffinized and processed, then stained with nuclear dye YO-PRO-1 (blue) and an anti-CD8 antibody (yellow). ?? Optical Clearing: Modified iDISCO+ protocol ?? Imaging: 2 μm/pixel resolution using the hybrid open-top light-sheet microscope from Alpenglow Biosciences (the 3Di). ?? Analysis: CD8+ lymphocytes were quantified in the entire tissue section (approx. 6 mm x 4.3 mm x 4.2 mm) using advanced 3D spatial analysis tools. What makes 3D imaging a game-changer here? ?? It enables us to clearly visualize crypt morphology in colorectal tissue, offering an unmatched view of the structural details vital to understanding tissue organization and pathology. ?? Lymphocyte density varies dramatically depending on section depth, which you can see starting at sec 14 as we virtually "section" through the tissue. ?? This variability highlights the power of 3D imaging to uncover insights that traditional 2D sections can’t reveal. Want more data and insights? ?? Next week, we’ll dive deeper into the full SITC poster and CD8+ cell quantification across the entire tissue. Stay tuned for Poster #119 at the upcoming Multi-Omics Event to explore additional groundbreaking findings! #3Dimaging #Histology #CancerResearch #LightSheetMicroscopy #Innovation

Join Jasmine Wilson, PhD., Principal Data Scientist as she presents her poster at Multi-Omics Brisbane! See how 3D imaging can help reveal the underlying biology and how our data analysis tools can help you extract deep insights from 3D data sets.

?? Exciting Announcement: Unveiling 3D Spatial Biology at Multi-Omics Brisbane 2024! Join us for a transformative poster presentation that dives deep into the world of immune cell dynamics, leveraging the power of cutting-edge 3D tissue-scale analysis. ?? Poster Title: 3D Tissue Scale Automated Segmentation with Alpenglow 3Dai Spatial Analysis Suite ?? Poster ID: #119 ?? Presented by: Jasmine Wilson, Principal Data Scientist, Alpenglow Biosciences ?? What to Expect: ? Advanced 3D Imaging: Explore how Alpenglow's revolutionary 3Di? light-sheet microscope uncovers neutrophils' diverse morphologies and functional states in intact tissues. ? Automated Segmentation: Discover the power of 3Dai? tools for rapid, precise segmentation of neutrophil elastase-labeled cells and nuclei. ? Beyond 2D Limitations: Witness the unparalleled detail of 3D imaging, revealing cellular structures and aggregates often missed in 2D histology. ? Research Impact: See how these insights elevate immune cell state analysis, opening doors for disease-context correlations and advancing our understanding of complex biological systems. Let’s innovate together at Multi-Omics Brisbane 2024! See you at Poster #119. ?? #3DSpatialBiology #MultiOmics2024 #Innovation #ScientificResearch #AlpenglowBiosciences

?? Happy #FluorescenceFriday! ?? Today, we’re thrilled to share a leap forward in 3D imaging that brings the complex architecture of human placenta tissue to life. Imagine diving into a world where every detail, every layer, is brought into focus, showcasing the intricate beauty of human biology like never before. With our proprietary tools, 3Dm and 3Dai, we’re taking visualization to the next level. These platforms allow us to move seamlessly from stunning 3D imagery to detailed image segmentation, unlocking insights essential for comprehensive data analysis. This technology enables us to capture and segment the unique details of each specific stain, revealing structural nuances that push the boundaries of spatial biology. We're continually amazed by what we uncover and excited to share these advancements with the world! ?? Join us as we explore the future of imaging and data-driven insights. Let’s continue to be inspired by the power of biology in 3D! #Innovation #SpatialBiology #3DImaging #LifeSciences #PlacentaImaging

Happy #LearningWednesday! Today, we summarize the concepts beautifully expressed in this article on Nature: https://lnkd.in/dAZZA9_Z. Discussing breakthroughs from the Human Tumor Atlas Network (HTAN) and the recent publication -Spatial Awareness- https://lnkd.in/e-p-Rnws ?? Through 3D mapping at the single-cell level, scientists are reshaping approaches to cancer diagnosis, treatment, and prevention. Nature’s “Spatial awareness” collection highlights how detailed 3D cellular mapping unveils tumor structures across various cancers, enabling researchers to pinpoint each cell's location and molecular state within tumors. This approach reveals critical insights into how cancers evolve and interact with surrounding tissue. HTAN’s creation of cellular maps for breast, pancreatic, and colon cancers has underscored a crucial finding: tumors are not uniform. Different regions within a single tumor can respond uniquely to treatments, demonstrating the need for highly targeted therapies tailored to each region's specific molecular makeup. Additionally, 3D mapping reveals the earliest molecular shifts that can indicate cancer risk. For instance, researchers observed DNA and gene activity changes associated with immune responses and hormone regulation in pre-cancerous lesions like colon polyps. Detecting these early markers presents an opportunity for prevention, as doctors could intervene before cellular changes turn irreversible. For immunotherapy, 3D mapping reveals valuable insights impossible with classical 2D technologies. In breast cancer, which often resists immunotherapies, 3D mapping shows that immune cells are distributed unevenly. Some tumor areas contain "exhausted" immune cells that are ineffective in combatting cancer. This information helps scientists understand why tumors can evade immune-based treatments and points toward strategies to boost immunotherapy’s success against resistant cancers. In colorectal cancer research, scientists have used CRISPR gene-editing to establish a “molecular clock” that tracks cellular changes over time. This method has shown that many colon polyps are more complex than previously thought, often involving multiple cell types rather than stemming from a single mutated cell. As a result, assessing cancer risk may require new biomarkers that capture genetic changes over time, revealing tumors’ behavior beyond just size. ?? These 3D mapping advances are opening a new chapter in cancer research, transforming our understanding of how tumors function, evolve, and can be targeted. By viewing cancer in previously unseen detail, scientists can now track cellular contributions to tumor growth and identify intervention points, offering hope for more precise, early, and individualized treatment approaches. The video was captured using our 3Di Hybrid open-top light-sheet microscope; more info: https://lnkd.in/dhQKJ7wU https://lnkd.in/dzCVvGxe

?? After an incredible dinner event yesterday, no time to rest! —today, we dive even deeper! If you are at #SITC, don’t miss the chance to hear from our own Nathan Grant as he presents "3D Spatial Quantification of CD8+ T-Cells in the Tumor Microenvironment in Intact FFPE Cancer Blocks Using the 3D I/O Pro Pipeline." Join us at Poster #93 to discover cutting-edge data and unique insights from our 3D tissue imaging platform. This approach brings a new perspective to advancing our understanding of immune cells in the TME. Nate is enthusiastic about sharing valuable insights from his extensive experience! Looking forward to meaningful discussions. Schedule time to connect with us today and tomorrow. We’re excited to talk science and share how our work is pushing boundaries in cancer research. https://lnkd.in/dBkpipiC ?? What an incredible experience yesterday with our dinner lecture! A huge thank you to all attendees and our esteemed speaker, Professor Pei-Ling Chen, for sharing her insights and expertise. #CancerResearch #3DImaging #TumorMicroenvironment #CD8TCells #SpatialBiology #3DQuantification #ImmunoOncology #FFPE