Age Management Medicine Group (AMMG)

Study uncovers potential new target for treatment of chronic, debilitating skin disease via ScienceDaily: https://bit.ly/3OnBBTJ. "A team of researchers at Clemson University used an innovative multiomics approach to identify key immune mechanisms in a chronic and debilitating inflammatory skin condition. The research, which was published in the journal Proceedings of the National Academy of Sciences (PNAS), offers a promising target for future therapies. Hidradenitis suppurativa (HS) is an immune disease that affects up to 4% of the global population and causes painful, recurring skin lesions and inflammation, primarily in the folds of the skin. It commonly affects women of African American descent. Shahid Mukhtar and his team -- Bharat Mishra, Nilesh Kumar and graduate student YiFei Gou -- used single-cell sequencing techniques to pinpoint CD2 as a key immune receptor with elevated expression on T cells and innate lymphoid cells (ILCs), including natural killer cells, in HS-affected skin tissue. In collaboration with researchers at the University of Alabama at Birmingham, Mukhtar's team demonstrated through organotypic skin culture experiments from HS patients that blocking CD2 led to a significant reduction in cytokine and chemokine production, along with suppression of key pathogenic gene signatures. This finding suggests that blocking CD2 may effectively reduce the inflammatory response in HS, providing a potential new therapeutic avenue for managing symptoms and improving patient quality of life." READ MORE HERE: https://bit.ly/3OnBBTJ #TreatingChronicSkinDisease #AMMG #AgeManagementMedicine #CMEEducation #ContinuingMedicalEducation #CMEConferences

Neuropathic pain drugs found to increase risk of hip fracture in older adults via ScienceDaily: https://bit.ly/3Z5dnDM. "The study, published today in JAMA Network Open, tracked patients hospitalised for hip fractures in Victoria, Australia from March 2013 through June 2018, who had used gabapentinoids before the injury. Often seen as a safer alternative to opioids for the treatment of neuropathic pain, gabapentinoid use increased eightfold between 2012 and 2018, with one in seven Australians aged 80 and older prescribed a gabapentinoid during this period. Currently, gabapentinoids are within the ten most subsidised medications by volume in Australia. Study co-author and Director of the Centre for Medicine Use and Safety (CMUS) at the Monash Institute of Pharmaceutical Sciences, Professor Simon Bell, said gabapentinoids can be effective for neuropathic pain but can also result in adverse events including dizziness, gait disturbance and balance disorder. The researchers analysed the data for 28,293 patients who experienced hip fractures across a five-year period. "Our results showed patients had 30 per cent increased odds of suffering a hip fracture within two months of being dispensed a gabapentinoid medication," Professor Bell said. "The link between gabapentinoids and hip fractures existed across different age groups but the odds of hip fracture was higher among patients who were frailer or had chronic kidney disease, so these should be important considerations when deciding when to prescribe gabapentinoids." However, Professor Bell stressed the importance of patients discussing with their doctor or pharmacist first before deciding to discontinue treatment." READ MORE HERE: https://bit.ly/3Z5dnDM #NeuropathicPainDrugs #HipFracture #Gabapentinoids #AMMG #AgeManagementMedicine #CMEEducation #ContinuingMedicalEducation #CMEConferences

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From the AMMG eJournal, Study Finds Link Between Too Much Niacin Intake and Heart Disease: https://bit.ly/3Zf5QCG. "A major new study shows excessive amounts of the common B vitamin niacin can lead to increased risk for cardiovascular disease, researchers announced Monday. In a new study published in the journal Nature Medicine, scientists from the Cleveland Clinic say they have identified a strong link between 4PY, a breakdown product from excess niacin, and heart disease. The results are important because they uncover a previously unknown driver of heart disease, according to Dr. Stanley Hazen, director of Cleveland Clinic’s Center for Microbiome and Human Health and the study’s lead author." READ MORE HERE: https://bit.ly/3Zf5QCG #HeartDisease #Niacin #AMMGeJournal #AMMG #AgeManagementMedicine #CMEEducation #ContinuingMedicalEducation #CMEConferences

Here's What Our Attendees Are Saying About AMMG! Join us in Miami, Florida on April 23 - 27, 2025 for the 38th Clinical Applications for Age Management Medicine Conference! SAVE THE DATE: www.agemed.org #AMMG #AgeManagementMedicine #CMEEducation #ContinuingMedicalEducation #CMEConferences #AMMGSpring2025

?? Save the date! ?? Plan ahead for AMMG's next two Age Management Medicine CME Conferences! ??? Have questions? Don't hesitate to reach out: [email protected]. We can't wait to see you all there! ?? SPRING: April 23 - 27, 2025 - National Doral Miami Resort & Spa - Miami, FL ?? FALL: November 12 - 16, 2025 - The Grand America Hotel - Salt Lake City, UT #AMMG #CMEConference #AgeManagementMedicine #SaveTheDate #HealthcareEvent #CMEEducation #ContinuingMedicalEducation #CMEConferences #AMMGSpring2025 #AMMGFall2025

From the AMMG eJournal, Major Breakthrough in Alzheimer’s Treatment: https://bit.ly/3ZbELz5. "A groundbreaking clinical study using focused ultrasound (FUS) technology for the treatment of Alzheimer’s disease has been reported in The New England Journal of Medicine, announced by Insightec, a global healthcare company. Conducted with WVU Rockefeller Neuroscience Institute (RNI), the study presents a novel treatment approach combining focused ultrasound to open the blood-brain barrier with systemic monoclonal antibody infusion. This method significantly enhances the removal of cerebral beta-amyloid, a key indicator of Alzheimer’s disease, showing potential in targeted drug delivery for neurological conditions. READ MORE HERE: https://bit.ly/3ZbELz5 #AlzheimersTreatment #AMMG #AgeManagementMedicine #CMEEducation #ContinuingMedicalEducation #CMEConferences

Shedding light on how oral bacteria can aggravate rheumatoid arthritis via ScienceDaily: https://bit.ly/3N0WnYr. "Periodontal disease, which affects the gums and tissues that surround the teeth, is one of the most prevalent dental conditions worldwide. Most often caused by the formation and accumulation of bacterial biofilm around the teeth, periodontal disease can ultimately lead to tooth loss if left unattended. Interestingly, the inflammatory effects of periodontal bacteria can go well beyond the mouth, leading to systemic effects. Over the past few decades, clinical studies have revealed that the periodontal pathogen Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) is closely related to the onset and worsening of rheumatoid arthritis (RA), a serious autoimmune disease that affects joints. However, what goes down at the molecular level remains largely unexplored and unclear. In a recent study published online on 15 August 2024, in International Journal of Oral Science, a research team from Tokyo Medical and Dental University (TMDU) in Japan sought to fill this knowledge gap through detailed mechanistic studies in an animal model. First, the researchers conducted preliminary experiments to confirm whether A. actinomycetemcomitans infection influenced arthritis in mice. To this end, they used the collagen antibody-induced arthritis mouse model, which is a well-established experimental model that mimics several aspects of RA in humans. They found that infection with this specific bacterium led to increased limb swelling, cellular infiltration into the lining of the joints, and higher levels of the inflammatory cytokine interleukin-1β (IL-1β) within the limbs. Notably, these symptoms of worsening RA could be suppressed by administering a chemical agent called clodronate that depletes macrophages -- a type of immune cell. This demonstrated that macrophages were somehow involved in aggravating RA caused by A. actinomycetemcomitans infection." READ MORE HERE: https://bit.ly/3N0WnYr #RheumatoidArthritis #OralBacteria #AMMG #AgeManagementMedicine #CMEEducation #ContinuingMedicalEducation #CMEConferences

Unlocking the energy crisis in Parkinson's: New findings offer hope for future treatment via ScienceDaily: https://bit.ly/4dFB3mx. "A recent study from the School of Medicine at Fujita Health University has brought new insights into the metabolic disruptions experienced by patients with PD. By analyzing the blood and cerebrospinal fluid (CSF) of the patients, researchers have discovered critical impairments in purine metabolism and the recycling of adenosine triphosphate (ATP) -- the molecule responsible for energy production in cells. For years, scientists have noted the decreased levels of uric acid in patients with PD. Uric acid, a compound known for its antioxidant properties, was initially thought to play a direct role in the disease by reducing oxidative stress in the brain. However, this study, published in NPJ Parkinson's Disease on 09 September 2024 reveals that the situation is more complex. ""Our findings suggest that decreased uric acid levels in patients with PD are influenced by factors beyond purine metabolism, including external factors such as sex, weight, and age,"" said Dr. Watanabe, the lead author of the study. ""This means the relationship between uric acid and PD is more nuanced than we previously thought, and it's about more than just oxidative stress."" By assessing the levels of purine metabolites, including inosine, hypoxanthine, xanthine, and uric acid, using a technique called targeted metabolomics, they found that patients with PD have significantly lower levels of uric acid in both serum and CSF compared to healthy controls. Additionally, the levels of hypoxanthine, another purine metabolite, were reduced." READ MORE HERE: https://bit.ly/4dFB3mx #ParkinsonsDisease #AMMG #AgeManagementMedicine #CMEEducation #ContinuingMedicalEducation #CMEConferences

From the AMMG eJournal, Proteins in Blood Can Predict Dementia 15 Years Before Diagnosis, Study Suggests: https://bit.ly/3O3RCOt. "A blood test that looks for changes in certain proteins could predict dementia up to 15 years before diagnosis, research suggests. Scientists have identified 11 proteins that they say are highly accurate (more than 90 per cent) at predicting future dementia. These proteins, found in the liquid component of blood known as the plasma, are markers for the biological changes that happen in people who have dementia or Alzheimer’s disease." READ MORE HERE: https://bit.ly/3O3RCOt #BrainHealth #PredictingDementia #AMMG #AgeManagementMedicine #CMEEducation #ContinuingMedicalEducation #CMEConferences