Additional Ventures

We are very proud to announce the launch of Single Ventricle SOURCE, a groundbreaking initiative that will transform our understanding of single ventricle heart disease and open new doors to innovative treatments and therapies.? ? SOURCE is the largest and most ambitious study of its kind, aimed at uncovering the genetic causes behind #singleventricle #congenitalheartdisease and its associated complications and comorbidities. SOURCE will enroll at least 5,000 single ventricle patients and 5,000 of their immediate family members to collect medical histories and genetic data through whole genome sequencing. Along with DNA samples, patients will also contribute their cardiac medical records, creating the world’s largest and most comprehensive genetic database for single ventricle heart disease. By contributing their genetic and clinical data, single ventricle patients and families will directly shape the future of research and help drive discoveries to improve care and outcomes. SOURCE is a game-changer for single ventricle research - and the future of single ventricle heart disease research is brighter than ever before! ?? Single Ventricle SOURCE is open for enrollment today! Learn more: www.svsource.org

One week left! ?? Submit your strategies by Tuesday, March 25, 2025.

It’s an exciting day for the single ventricle research community. ?? After a record number of submissions, 13 outstanding proposals have been selected for funding through the 2025 Additional Ventures Expansion Award! Collectively, there’s so much to celebrate about these projects. Not only do they span a number of fields, including neuroscience, stem cell biology, imaging, and bioengineering, but they also explore multiple organ systems beyond the heart, such as the lung, liver, and brain. Plus, nearly one-third of the awardees (31%) are new to the single ventricle space. Congratulations to all the investigators and teams whose proposals were selected for the 2025 Additional Ventures Expansion Award! Primary investigators: ?? Daniel Castellanos, MD? ?? Eamon Doyle, PhD ?? Nicole Dubois, PhD ?? Whitney Edwards, PhD ?? Bruce Johnson, PhD ?? Sonnet Jonker, PhD ?? Kyle Loh, PhD ?? Yibing Qyang, PhD ?? Caitlin Rollins, MD, SM ?? Vahid Serpooshan, PhD ?? Daniel Shiwarski, PhD ?? Colleen Witzenburg, PhD ?? Quan Zhu, PhD We’re confident that your scientific progress will fuel lasting impact through new findings and advancements that ultimately revolutionize single ventricle treatment and care. ?? If you’d like to learn more about the 2025 Expansion Award investigators and their projects, view the full announcement: https://lnkd.in/etupdhPT

The American Heart Association and Additional Ventures seek information that could inform innovative approaches to improve heart transplant patient outcomes. Examples include enhanced interventions, including clinical trials, policies, or novel data analyses. As part of a comprehensive research analysis, we invite investigators, individuals with lived experience, institutions, or pharmaceutical/device entities to provide insights into the critical areas of heart transplantation that must be transformed to significantly improve outcomes for these patients.

Clinicians working in or near the pediatric cardiology space, we invite you to learn more about the Single Ventricle SOURCE genomic sequencing study this #CHDAwareness Week. #cardiology #HeartMonth #congenitalheartdefects

As we continue to celebrate #HeartMonth, I want to highlight the amazing work of one of our funded investigators Mark Skylar-Scott, who is breaking barriers in organ-scale bioprinting and making science fiction just (really cool) science. Taking giant leaps in science requires a multi-disciplinary approach and visionary thinking - and Mark is doing just that. Alongside his creativity and ingenuity in his own lab, he is part of the Additional Ventures Cures Collaborative, a team of 8 labs across the country scientists, who are creating a bioprinted pulsatile conduit to functionally cure single ventricle physiology, and leads a 15+ lab team at Stanford University funded by Advanced Research Projects Agency for Health (ARPA-H) to print a whole heart! Check out Mark's amazing work below! #3Dprinting #TissueEngineering

Today, we are proud to announce the 2025 Catalyst to Independence Award Program Fellows, the newest cohort in our #singleventricle focused postdoctoral to tenure-track faculty grant program. These awardees demonstrate a commitment to pursuing impactful single ventricle research as they transition from their postdoctoral positions to independent research faculty. We are thrilled to welcome them as Catalyst Award Fellows! ?? Dr. Diwakar Turaga, an attending physician in the Intensive Care Unit at Texas Children's Hospital and postdoctoral trainee in Dr. James Martin's lab at Baylor College of Medicine, will investigate the FOXO family of transcription factors and their role in pediatric heart failure. Dr. Turaga's research will provide novel insights into the mechanisms of FOXO-mediated pediatric heart failure and avenues for new therapeutic development. ?? Dr. Jaci Bliley is a postdoctoral fellow co-mentored by Dr. Adam Feinberg at Carnegie Mellon University and Dr. Nicole Dubois at the Icahn School of Medicine at Mt. Sinai University. Through a unique combination of bioengineering and developemental biology, Dr. Bliley will create a novel bioprinted model of heart valve development to understand the origins of single ventricle disease. Dr. Bliley's novel model and research will provide new insights in the impact of fluid forces and genetics on early cardiogenesis. The addition of these two outstanding early career scientists to our current Catalyst cohort means the future of single ventricle research is bright! To read more about the Catalyst to Independence Award and our newest fellows, visit our website: https://lnkd.in/eUCgmrsS

Wow. SVIM 2024 was extraordinary ?? Our heartfelt thanks to all those who attended, supported, and participated in the Single Ventricle Investigator Meeting. The catalytic energy and inspiration we experienced in Denver are palpable, and we are profoundly grateful to work alongside such a dedicated and passionate community. The journey to curative solutions won’t be easy, but by working together, we can truly change the future for single ventricle patients. Download the 2024 Agenda & Abstract Book ?? https://lnkd.in/dDfZXX67

?? Exciting News from the Alliance for Pediatric Device Innovation! In collaboration with Children's National Hospital, we are thrilled to support six groundbreaking innovations set to transform pediatric healthcare. These innovative technologies hold incredible promise for advancing care for our smallest heart patients. Congratulations to all our awardees! Read more: https://lnkd.in/dB3ANqW6

We're proud to partner with the Alliance for Pediatric Device Innovation, led by Children's National Hospital, on this important initiative. The "Make Your Medical Device for Kids!" competition prioritizes innovation in pediatric cardiovascular devices and supports the critical need to develop and commercialize new technologies built for children. Congratulations to the ten groups selected to compete! We look forward to seeing these and other breakthroughs reach patients and revolutionize how we treat and monitor children. News Release: https://lnkd.in/eb_kYkB5