3Helix, Inc.

https://lnkd.in/eeCTBcHa Precision in scientific research matters, and our CHPs deliver: We're excited to share how our CHPs were instrumental in a study providing the first definitive proof of collagen denaturation in bone fracture. Researchers at the University of Waterloo used F-CHP to visualize and quantify collagen damage, revealing critical insights into bone mechanics. This research underscores the accuracy and reliability of CHPs for molecular-level analysis. At 3Helix, we're committed to providing you with tools you need to make groundbreaking discoveries. Read the full story here: https://lnkd.in/eeCTBcHa

Beyond renal dysfunction, why do CKD patients experience such profound muscle weakness? Maybe the answer lies in localized muscle fibrosis; a factor often overshadowed by kidney-centric research... ?? A recent study tackled this question head-on, investigating the role of muscle fibrosis in CKD. The problem? Traditional methods often fall short in capturing the dynamic nature of collagen remodeling. That's where Collagen Hybridizing Peptides (CHPs) stepped in. By utilizing CHPs, researchers precisely visualized and quantified denatured collagen to reveal a significant increase in both total and damaged collagen in CKD patient muscle, correlating with muscle weakness. This research highlights the power of CHPs in unraveling complex biological processes and opens new avenues for therapeutic intervention. How can we leverage these insights to improve patient outcomes? Explore the study: https://lnkd.in/e_NrrHgM #CKD #MuscleHealth #ExtracellularMatrix #CHPs #ResearchTools #Biotechnology #3Helix #Collagen"

Building a Better Model: Refining Our Understanding of Collagen While W.T. Astbury's X-ray diffraction studies in the 1930s revealed collagen's regular molecular structure, it was Linus Pauling and Robert Corey's 1951 paper "The structure of Fibrous Proteins of the Collagen-Gelatin Group" that significantly refined our understanding of its architecture. Their work represents a crucial step in the journey towards elucidating the triple helix. Building on Astbury's initial observations of fibrous protein structure, Pauling and Corey applied their expertise in protein crystallography to develop more precise models. Their approach was characterized by rigorous analysis of bond lengths, angles, and steric constraints, leveraging their established understanding of peptide geometry. Key contributions: ??? Refinement of Structural Models: They moved beyond Astbury's general coiled structure, proposing more detailed atomic arrangements. ?? Emphasis on Peptide Geometry: Their work highlighted the importance of accurate bond parameters in protein modeling, ensuring physically realistic structures. ?? Foundation for Triple Helix Interpretation: Their refined models provided a crucial stepping stone for subsequent researchers, including Ramachandran, to develop the accurate triple helical structure. Pauling and Corey's methodical approach and deep understanding of chemical bonding allowed them to build upon Astbury's pioneering work, paving the way for the ultimate resolution of collagen's complex structure. These findings in collagen provided a deeper understanding of the 3D structure of collagen proteins?which was a fundamental stepping stone to the invention of collagen hybridizing peptide technology. #collagen #proteinchemistry #structuralbiology #LinusPauling #RobertCorey #crystallography #biochemistry

Beyond renal dysfunction, why do CKD patients experience such profound muscle weakness? Maybe the answer lies in localized muscle fibrosis; a factor often overshadowed by kidney-centric research... ?? A recent study tackled this question head-on, investigating the role of muscle fibrosis in CKD. The problem? Traditional methods often fall short in capturing the dynamic nature of collagen remodeling. That's where Collagen Hybridizing Peptides (CHPs) stepped in. By utilizing CHPs, researchers precisely visualized and quantified denatured collagen to reveal a significant increase in both total and damaged collagen in CKD patient muscle, correlating with muscle weakness. This research highlights the power of CHPs in unraveling complex biological processes and opens new avenues for therapeutic intervention. How can we leverage these insights to improve patient outcomes? Explore the study: https://lnkd.in/e_NrrHgM #CKD #MuscleHealth #ExtracellularMatrix #CHPs #ResearchTools #Biotechnology #3Helix #Collagen"

We're thrilled to welcome two exceptional individuals to our growing team! Please join us in extending a warm welcome to Bridget Glass & Kyle Dunlap, PhD!

??Friday (2/28) was Rare Disease Day - we stand in solidarity with the millions of people affected by rare diseases worldwide. At 3Helix, we understand that such conditions often present unique challenges, especially when they involve complex tissue damage and remodeling. ??Our Collagen Hybridizing Peptides (CHPs) are helping researchers around the globe gain deeper insights into rare diseases which affect connective tissues, such as Ehlers-Danlos Syndrome, Osteogenesis Imperfecta, and various forms of fibrosis. By enabling precise visualization and quantification of damaged collagen???, CHPs are opening new doors for early diagnosis, better understanding of disease progression, and more targeted therapies. On this Rare Disease Day, we reaffirm our commitment to advancing research and providing tools that help scientists and clinicians push the boundaries of what’s possible in rare disease studies. #RareDiseaseDay #ShareYourColours

How does a cell construct collagen, a robust protein essential for tissue strength, without its components solidifying prematurely within its confines? The discovery of procollagen in the 1970s resolved this fundamental paradox in collagen biosynthesis: the intracellular transport of a protein destined for extracellular fibril formation. Procollagen, a precursor molecule characterized by N- and C-terminal propeptides, makes for a soluble, transportable form of collagen. The terminal propeptides are critical in preventing premature intracellular fibrillogenesis, a process that would otherwise result in cellular dysfunction. Extracellular procollagen peptidases? subsequently cleave these propeptides to create tropocollagens, which self-assemble with other tropocollagen molecules into mature collagen fibrils. This discovery significantly advanced our understanding of connective tissue biology, with implications for: ?? Pathogenesis of Connective Tissue Disorders ??? Mechanisms of Fibrosis ?? Regulation of Extracellular Matrix Assembly The work of researchers like George Martin and Karl Piez provided a critical framework for investigating the complex regulatory mechanisms governing collagen biosynthesis and its role in ECM homeostasis.

How does a cell construct collagen, a robust protein essential for tissue strength, without its components solidifying prematurely within its confines? The discovery of procollagen in the 1970s resolved this fundamental paradox in collagen biosynthesis: the intracellular transport of a protein destined for extracellular fibril formation. Procollagen, a precursor molecule characterized by N- and C-terminal propeptides, makes for a soluble, transportable form of collagen. The terminal propeptides are critical in preventing premature intracellular fibrillogenesis, a process that would otherwise result in cellular dysfunction. Extracellular procollagen peptidases? subsequently cleave these propeptides to create tropocollagens, which self-assemble with other tropocollagen molecules into mature collagen fibrils. This discovery significantly advanced our understanding of connective tissue biology, with implications for: ?? Pathogenesis of Connective Tissue Disorders ??? Mechanisms of Fibrosis ?? Regulation of Extracellular Matrix Assembly The work of researchers like George Martin and Karl Piez provided a critical framework for investigating the complex regulatory mechanisms governing collagen biosynthesis and its role in ECM homeostasis.

February is American Heart Month! ?? This infographic highlights how Collagen Hybridizing Peptides are helping researchers study and develop treatments for cardiovascular diseases. Learn more at 3helix.com or contact us to discuss your research needs! #AmericanHeartMonth #Biotechnology #CollagenResearch

Just a little taste of the ??? winter wonderland ?? outside the office window today. Salt Lake City showing off. Drive safe, SLC Friends! ?? #SLC #SnowDay #UtahWinter